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Mastocytosis
Donna G. Blankenbaker, MD, FACR; B. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Definitions

          • Heterogeneous, neoplastic disorder that results from clonal mast cell proliferation in various organs
            • Most commonly involves skeletal system

        IMAGING

        • General Features

          • Radiographic Findings

            • CT Findings

              • MR Findings

                • Nuclear Medicine Findings

                  CLINICAL ISSUES

                  • Presentation

                    • Demographics

                      • Natural History & Prognosis

                        • Treatment

                          Selected References

                          1. Ozturk K et al: Non-hematologic diagnosis of systemic mastocytosis: collaboration of radiology and pathology. Blood Rev. 100693, 2020
                          2. Riffel P et al: Magnetic resonance imaging reveals distinct bone marrow patterns in indolent and advanced systemic mastocytosis. Ann Hematol. 98(12):2693-701, 2019
                          3. Epelboym Y et al: Differences in the imaging features and distribution of non-indolent and indolent mastocytosis: a single institution experience of 29 patients. Clin Imaging. 44:111-6, 2017
                          4. Alpay Kanıtez N et al: Osteoporosis and osteopathy markers in patients with mastocytosis. Turk J Haematol. 32(1):43-50, 2015
                          5. Arock M et al: Current treatment options in patients with mastocytosis: status in 2015 and future perspectives. Eur J Haematol. 94(6):474-90, 2015
                          6. Gasljevic G et al: Hodgkin's lymphoma is a rare form of clonal haematological non-mast cell disease in systemic mastocytosis. Diagn Pathol. 10(1):5, 2015
                          7. Pardanani A: Systemic mastocytosis in adults: 2015 update on diagnosis, risk stratification, and management. Am J Hematol. 90(3):250-62, 2015
                          8. Fritz J et al: Advanced imaging of skeletal manifestations of systemic mastocytosis. Skeletal Radiol. 41(8):887-97, 2012
                          9. Bains SN et al: Current approaches to the diagnosis and treatment of systemic mastocytosis. Ann Allergy Asthma Immunol. 104(1):1-10; quiz 10-2, 41, 2010
                          10. Pardanani A et al: Systemic mastocytosis in adults: a review on prognosis and treatment based on 342 Mayo Clinic patients and current literature. Curr Opin Hematol. 17(2):125-32, 2010
                          11. Krüger A et al: Multimodal therapy for vertebral involvement of systemic mastocytosis. Spine (Phila Pa 1976). 34(17):E626-8, 2009
                          12. Lim KH et al: Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors. Blood. 113(23):5727-36, 2009
                          13. Mathew R et al: Systemic mastocytosis presenting as osteoporosis--a case report. Clin Rheumatol. 28(7):865-6, 2009
                          14. Nguyen BD: CT and scintigraphy of aggressive lymphadenopathic mastocytosis. AJR Am J Roentgenol. 178(3):769-70, 2002
                          15. Zettinig G et al: FDG positron emission tomography in patients with systemic mastocytosis. AJR Am J Roentgenol. 179(5):1235-7, 2002
                          16. Avila NA et al: Systemic mastocytosis: CT and US features of abdominal manifestations. Radiology. 202(2):367-72, 1997
                          Related Anatomy
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                          References
                          Tables

                          Tables

                          KEY FACTS

                          • Terminology

                            • Imaging

                              • Clinical Issues

                                TERMINOLOGY

                                • Definitions

                                  • Heterogeneous, neoplastic disorder that results from clonal mast cell proliferation in various organs
                                    • Most commonly involves skeletal system

                                IMAGING

                                • General Features

                                  • Radiographic Findings

                                    • CT Findings

                                      • MR Findings

                                        • Nuclear Medicine Findings

                                          CLINICAL ISSUES

                                          • Presentation

                                            • Demographics

                                              • Natural History & Prognosis

                                                • Treatment

                                                  Selected References

                                                  1. Ozturk K et al: Non-hematologic diagnosis of systemic mastocytosis: collaboration of radiology and pathology. Blood Rev. 100693, 2020
                                                  2. Riffel P et al: Magnetic resonance imaging reveals distinct bone marrow patterns in indolent and advanced systemic mastocytosis. Ann Hematol. 98(12):2693-701, 2019
                                                  3. Epelboym Y et al: Differences in the imaging features and distribution of non-indolent and indolent mastocytosis: a single institution experience of 29 patients. Clin Imaging. 44:111-6, 2017
                                                  4. Alpay Kanıtez N et al: Osteoporosis and osteopathy markers in patients with mastocytosis. Turk J Haematol. 32(1):43-50, 2015
                                                  5. Arock M et al: Current treatment options in patients with mastocytosis: status in 2015 and future perspectives. Eur J Haematol. 94(6):474-90, 2015
                                                  6. Gasljevic G et al: Hodgkin's lymphoma is a rare form of clonal haematological non-mast cell disease in systemic mastocytosis. Diagn Pathol. 10(1):5, 2015
                                                  7. Pardanani A: Systemic mastocytosis in adults: 2015 update on diagnosis, risk stratification, and management. Am J Hematol. 90(3):250-62, 2015
                                                  8. Fritz J et al: Advanced imaging of skeletal manifestations of systemic mastocytosis. Skeletal Radiol. 41(8):887-97, 2012
                                                  9. Bains SN et al: Current approaches to the diagnosis and treatment of systemic mastocytosis. Ann Allergy Asthma Immunol. 104(1):1-10; quiz 10-2, 41, 2010
                                                  10. Pardanani A et al: Systemic mastocytosis in adults: a review on prognosis and treatment based on 342 Mayo Clinic patients and current literature. Curr Opin Hematol. 17(2):125-32, 2010
                                                  11. Krüger A et al: Multimodal therapy for vertebral involvement of systemic mastocytosis. Spine (Phila Pa 1976). 34(17):E626-8, 2009
                                                  12. Lim KH et al: Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors. Blood. 113(23):5727-36, 2009
                                                  13. Mathew R et al: Systemic mastocytosis presenting as osteoporosis--a case report. Clin Rheumatol. 28(7):865-6, 2009
                                                  14. Nguyen BD: CT and scintigraphy of aggressive lymphadenopathic mastocytosis. AJR Am J Roentgenol. 178(3):769-70, 2002
                                                  15. Zettinig G et al: FDG positron emission tomography in patients with systemic mastocytosis. AJR Am J Roentgenol. 179(5):1235-7, 2002
                                                  16. Avila NA et al: Systemic mastocytosis: CT and US features of abdominal manifestations. Radiology. 202(2):367-72, 1997