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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Definitions
- Meconium ileus (MI): Neonatal obstruction of distal ileum due to abnormally thick, tenacious meconium
- Up to 90% of MI patients have cystic fibrosis (CF)
- Presenting illness in 10-20% of CF newborns
- Complicated MI: Superimposed ischemia, volvulus, atresia, &/or perforation in up to 50% of MI cases
- Meconium ileus (MI): Neonatal obstruction of distal ileum due to abnormally thick, tenacious meconium
IMAGING
General Features
Radiographic Findings
Fluoroscopic Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Tsitsiou Y et al: Diagnostic decision-making tool for imaging term neonatal bowel obstruction. Clin Radiol. 76(3):163-71, 2021
- Galante G et al: Gastrointestinal, pancreatic, and hepatic manifestations of cystic fibrosis in the newborn. Neoreviews. 20(1):e12-4, 2019
- Schauble AL et al: N-acetylcysteine for management of distal intestinal obstruction syndrome. J Pediatr Pharmacol Ther. 24(5):390-7, 2019
- Gunderman PFR et al: Fetal MRI in management of complicated meconium ileus: prenatal and surgical imaging. Prenat Diagn. 38(9):685-91, 2018
- Rubio EI et al: Prenatal magnetic resonance and ultrasonographic findings in small-bowel obstruction: imaging clues and postnatal outcomes. Pediatr Radiol. 47(4):411-21, 2017
- Sathe M et al: Meconium ileus in cystic fibrosis. J Cyst Fibros. 16 Suppl 2:S32-9, 2017
- Kelly T et al: Gastrointestinal manifestations of cystic fibrosis. Dig Dis Sci. 60(7):1903-13, 2015
- Maxfield CM et al: A pattern-based approach to bowel obstruction in the newborn. Pediatr Radiol. 43(3):318-29, 2013
- Karimi A et al: Issues in the management of simple and complex meconium ileus. Pediatr Surg Int. 27(9):963-8, 2011
- van der Doef HP et al: Intestinal obstruction syndromes in cystic fibrosis: meconium ileus, distal intestinal obstruction syndrome, and constipation. Curr Gastroenterol Rep. 13(3):265-70, 2011
- Colombani M et al: Fetal gastrointestinal MRI: all that glitters in T1 is not necessarily colon. Pediatr Radiol. 40(7):1215-21, 2010
- Efrati O et al: Meconium ileus in patients with cystic fibrosis is not a risk factor for clinical deterioration and survival: the Israeli Multicenter study. J Pediatr Gastroenterol Nutr. 50(2):173-8, 2010
- Gorter RR et al: Clinical and genetic characteristics of meconium ileus in newborns with and without cystic fibrosis. J Pediatr Gastroenterol Nutr. 50(5):569-72, 2010
- Johnson JA et al: Does presenting with meconium ileus affect the prognosis of children with cystic fibrosis? Pediatr Pulmonol. 45(10):951-8, 2010
- Copeland DR et al: Diminishing role of contrast enema in simple meconium ileus. J Pediatr Surg. 44(11):2130-2, 2009
- Carcopino X et al: Use of fetal magnetic resonance imaging in differentiating ileal atresia from meconium ileus. Ultrasound Obstet Gynecol. 28(7):976-7, 2006
- Munck A et al: Clinical outcome of cystic fibrosis presenting with or without meconium ileus: a matched cohort study. J Pediatr Surg. 41(9):1556-60, 2006
- Lai HJ et al: Association between initial disease presentation, lung disease outcomes, and survival in patients with cystic fibrosis. Am J Epidemiol. 159(6):537-46, 2004
- Eckoldt F et al: Meconium peritonitis and pseudo-cyst formation: prenatal diagnosis and post-natal course. Prenat Diagn. 23(11):904-8, 2003
- Hajivassiliou CA: Intestinal obstruction in neonatal/pediatric surgery. Semin Pediatr Surg. 12(4):241-53, 2003
- Burke MS et al: New strategies in nonoperative management of meconium ileus. J Pediatr Surg. 37(5):760-4, 2002
- Oliveira MC et al: Effect of meconium ileus on the clinical prognosis of patients with cystic fibrosis. Braz J Med Biol Res. 35(1):31-8, 2002
- Berrocal T et al: Congenital anomalies of the small intestine, colon, and rectum. Radiographics. 19(5):1219-36, 1999
- De Backer AI et al: Radiographic manifestations of intestinal obstruction in the newborn. JBR-BTR. 82(4):159-66, 1999
- Feingold J et al: Genetic comparisons of patients with cystic fibrosis with or without meconium ileus. Clinical Centers of the French CF Registry. Ann Genet. 42(3):147-50, 1999
- Mushtaq I et al: Meconium ileus secondary to cystic fibrosis. the East London experience. Pediatr Surg Int. 13(5-6):365-9, 1998
- Buonomo C: Neonatal gastrointestinal emergencies. Radiol Clin North Am. 35(4):845-64, 1997
- Murshed R et al: Meconium ileus: a ten-year review of thirty-six patients. Eur J Pediatr Surg. 7(5):275-7, 1997
- Neal MR et al: Neonatal ultrasonography to distinguish between meconium ileus and ileal atresia. J Ultrasound Med. 16(4):263-6; quiz 267-8, 1997
- Kao SC et al: Nonoperative treatment of simple meconium ileus: a survey of the Society for Pediatric Radiology. Pediatr Radiol. 25(2):97-100, 1995
- Stringer MD et al: Meconium ileus due to extensive intestinal aganglionosis. J Pediatr Surg. 29(4):501-3, 1994
- Docherty JG et al: Meconium ileus: a review 1972-1990. Br J Surg. 79(6):571-3, 1992
- Leonidas JC et al: Meconium ileus and its complications. A reappraisal of plain film roentgen diagnostic criteria. Am J Roentgenol Radium Ther Nucl Med. 108(3):598-609, 1970
- Berdon WE et al: Microcolon in newborn infants with intestinal obstruction. Its correlation with the level and time of onset of obstruction. Radiology. 90(5):878-85, 1968
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Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Definitions
- Meconium ileus (MI): Neonatal obstruction of distal ileum due to abnormally thick, tenacious meconium
- Up to 90% of MI patients have cystic fibrosis (CF)
- Presenting illness in 10-20% of CF newborns
- Complicated MI: Superimposed ischemia, volvulus, atresia, &/or perforation in up to 50% of MI cases
- Meconium ileus (MI): Neonatal obstruction of distal ileum due to abnormally thick, tenacious meconium
IMAGING
General Features
Radiographic Findings
Fluoroscopic Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Tsitsiou Y et al: Diagnostic decision-making tool for imaging term neonatal bowel obstruction. Clin Radiol. 76(3):163-71, 2021
- Galante G et al: Gastrointestinal, pancreatic, and hepatic manifestations of cystic fibrosis in the newborn. Neoreviews. 20(1):e12-4, 2019
- Schauble AL et al: N-acetylcysteine for management of distal intestinal obstruction syndrome. J Pediatr Pharmacol Ther. 24(5):390-7, 2019
- Gunderman PFR et al: Fetal MRI in management of complicated meconium ileus: prenatal and surgical imaging. Prenat Diagn. 38(9):685-91, 2018
- Rubio EI et al: Prenatal magnetic resonance and ultrasonographic findings in small-bowel obstruction: imaging clues and postnatal outcomes. Pediatr Radiol. 47(4):411-21, 2017
- Sathe M et al: Meconium ileus in cystic fibrosis. J Cyst Fibros. 16 Suppl 2:S32-9, 2017
- Kelly T et al: Gastrointestinal manifestations of cystic fibrosis. Dig Dis Sci. 60(7):1903-13, 2015
- Maxfield CM et al: A pattern-based approach to bowel obstruction in the newborn. Pediatr Radiol. 43(3):318-29, 2013
- Karimi A et al: Issues in the management of simple and complex meconium ileus. Pediatr Surg Int. 27(9):963-8, 2011
- van der Doef HP et al: Intestinal obstruction syndromes in cystic fibrosis: meconium ileus, distal intestinal obstruction syndrome, and constipation. Curr Gastroenterol Rep. 13(3):265-70, 2011
- Colombani M et al: Fetal gastrointestinal MRI: all that glitters in T1 is not necessarily colon. Pediatr Radiol. 40(7):1215-21, 2010
- Efrati O et al: Meconium ileus in patients with cystic fibrosis is not a risk factor for clinical deterioration and survival: the Israeli Multicenter study. J Pediatr Gastroenterol Nutr. 50(2):173-8, 2010
- Gorter RR et al: Clinical and genetic characteristics of meconium ileus in newborns with and without cystic fibrosis. J Pediatr Gastroenterol Nutr. 50(5):569-72, 2010
- Johnson JA et al: Does presenting with meconium ileus affect the prognosis of children with cystic fibrosis? Pediatr Pulmonol. 45(10):951-8, 2010
- Copeland DR et al: Diminishing role of contrast enema in simple meconium ileus. J Pediatr Surg. 44(11):2130-2, 2009
- Carcopino X et al: Use of fetal magnetic resonance imaging in differentiating ileal atresia from meconium ileus. Ultrasound Obstet Gynecol. 28(7):976-7, 2006
- Munck A et al: Clinical outcome of cystic fibrosis presenting with or without meconium ileus: a matched cohort study. J Pediatr Surg. 41(9):1556-60, 2006
- Lai HJ et al: Association between initial disease presentation, lung disease outcomes, and survival in patients with cystic fibrosis. Am J Epidemiol. 159(6):537-46, 2004
- Eckoldt F et al: Meconium peritonitis and pseudo-cyst formation: prenatal diagnosis and post-natal course. Prenat Diagn. 23(11):904-8, 2003
- Hajivassiliou CA: Intestinal obstruction in neonatal/pediatric surgery. Semin Pediatr Surg. 12(4):241-53, 2003
- Burke MS et al: New strategies in nonoperative management of meconium ileus. J Pediatr Surg. 37(5):760-4, 2002
- Oliveira MC et al: Effect of meconium ileus on the clinical prognosis of patients with cystic fibrosis. Braz J Med Biol Res. 35(1):31-8, 2002
- Berrocal T et al: Congenital anomalies of the small intestine, colon, and rectum. Radiographics. 19(5):1219-36, 1999
- De Backer AI et al: Radiographic manifestations of intestinal obstruction in the newborn. JBR-BTR. 82(4):159-66, 1999
- Feingold J et al: Genetic comparisons of patients with cystic fibrosis with or without meconium ileus. Clinical Centers of the French CF Registry. Ann Genet. 42(3):147-50, 1999
- Mushtaq I et al: Meconium ileus secondary to cystic fibrosis. the East London experience. Pediatr Surg Int. 13(5-6):365-9, 1998
- Buonomo C: Neonatal gastrointestinal emergencies. Radiol Clin North Am. 35(4):845-64, 1997
- Murshed R et al: Meconium ileus: a ten-year review of thirty-six patients. Eur J Pediatr Surg. 7(5):275-7, 1997
- Neal MR et al: Neonatal ultrasonography to distinguish between meconium ileus and ileal atresia. J Ultrasound Med. 16(4):263-6; quiz 267-8, 1997
- Kao SC et al: Nonoperative treatment of simple meconium ileus: a survey of the Society for Pediatric Radiology. Pediatr Radiol. 25(2):97-100, 1995
- Stringer MD et al: Meconium ileus due to extensive intestinal aganglionosis. J Pediatr Surg. 29(4):501-3, 1994
- Docherty JG et al: Meconium ileus: a review 1972-1990. Br J Surg. 79(6):571-3, 1992
- Leonidas JC et al: Meconium ileus and its complications. A reappraisal of plain film roentgen diagnostic criteria. Am J Roentgenol Radium Ther Nucl Med. 108(3):598-609, 1970
- Berdon WE et al: Microcolon in newborn infants with intestinal obstruction. Its correlation with the level and time of onset of obstruction. Radiology. 90(5):878-85, 1968
