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Meconium Plug Syndrome
A. Carlson Merrow, Jr., MD, FAAP
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Meconium plug syndrome (MPS)
            • Synonyms

              • Small left colon syndrome
              • Functional immaturity of colon
            • Definitions

              • Transient functional obstruction of the newborn colon
                • Retained distal colonic meconium is secondary (not an underlying cause of mechanical obstruction)

            IMAGING

            • General Features

              • Radiographic Findings

                • Fluoroscopic Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Ellis H et al: Neonatal small left colon syndrome in the offspring of diabetic mothers-an analysis of 105 children. J Pediatr Surg. 44(12):2343-6, 2009
                                      2. Keckler SJ et al: Current significance of meconium plug syndrome. J Pediatr Surg. 43(5):896-8, 2008
                                      3. Burge D et al: Meconium plug obstruction. Pediatr Surg Int. 20(2):108-10, 2004
                                      4. Hajivassiliou CA: Intestinal obstruction in neonatal/pediatric surgery. Semin Pediatr Surg. 12(4):241-53, 2003
                                      5. De Backer AI et al: Radiographic manifestations of intestinal obstruction in the newborn. JBR-BTR. 82(4):159-66, 1999
                                      6. Lassmann G et al: Transient functional obstruction of the colon in neonates: examination of its development by manometry and biopsies. Prog Pediatr Surg. 24:202-16, 1989
                                      7. Hall SL et al: Neonatal intussusception associated with neonatal small left colon syndrome. Clin Pediatr (Phila). 26(4):191-3, 1987
                                      8. Amodio J et al: Microcolon of prematurity: a form of functional obstruction. AJR Am J Roentgenol. 146(2):239-44, 1986
                                      9. Ellerbroek C et al: Neonatal small left colon in an infant with cystic fibrosis. Pediatr Radiol. 16(2):162-3, 1986
                                      10. Johnson JF et al: Localized bowel distension in the newborn: a review of the plain film analysis and differential diagnosis. Pediatrics. 73(2):206-15, 1984
                                      11. Rosenfield NS et al: Hirschsprung disease: accuracy of the barium enema examination. Radiology. 150(2):393-400, 1984
                                      12. Cohen MD et al: Neonatal small left colon syndrome in twins. Gastrointest Radiol. 7(3):283-6, 1982
                                      13. Dunn V et al: Infants of diabetic mothers: radiographic manifestations. AJR Am J Roentgenol. 137(1):123-8, 1981
                                      14. Rangecroft L: Neonatal small left colon syndrome. Arch Dis Child. 54(8):635-7, 1979
                                      15. Berdon WE et al: Neonatal small left colon syndrome: its relationship to aganglionosis and meconium plug syndrome. Radiology. 125(2):457-62, 1977
                                      16. Ferrara TP et al: The radiology corner. Neonatal small left colon syndrome. Am J Gastroenterol. 68(6):608-12, 1977
                                      17. Stewart DR et al: Neonatal small left colon syndrome. Ann Surg. 186(6):741-5, 1977
                                      18. Davis WS et al: Neonatal small left colon syndrome. Occurrence in asymptomatic infants of diabetic mothers. Am J Dis Child. 129(9):1024-7, 1975
                                      19. Davis WS et al: Neonatal small left colon syndrome. Am J Roentgenol Radium Ther Nucl Med. 120(2):322-9, 1974
                                      20. Berdon WE et al: Microcolon in newborn infants with intestinal obstruction. Its correlation with the level and time of onset of obstruction. Radiology. 90(5):878-85, 1968
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Meconium plug syndrome (MPS)
                                                • Synonyms

                                                  • Small left colon syndrome
                                                  • Functional immaturity of colon
                                                • Definitions

                                                  • Transient functional obstruction of the newborn colon
                                                    • Retained distal colonic meconium is secondary (not an underlying cause of mechanical obstruction)

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • Fluoroscopic Findings

                                                      • Imaging Recommendations

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Gross Pathologic & Surgical Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      DIAGNOSTIC CHECKLIST

                                                                      • Consider

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Ellis H et al: Neonatal small left colon syndrome in the offspring of diabetic mothers-an analysis of 105 children. J Pediatr Surg. 44(12):2343-6, 2009
                                                                          2. Keckler SJ et al: Current significance of meconium plug syndrome. J Pediatr Surg. 43(5):896-8, 2008
                                                                          3. Burge D et al: Meconium plug obstruction. Pediatr Surg Int. 20(2):108-10, 2004
                                                                          4. Hajivassiliou CA: Intestinal obstruction in neonatal/pediatric surgery. Semin Pediatr Surg. 12(4):241-53, 2003
                                                                          5. De Backer AI et al: Radiographic manifestations of intestinal obstruction in the newborn. JBR-BTR. 82(4):159-66, 1999
                                                                          6. Lassmann G et al: Transient functional obstruction of the colon in neonates: examination of its development by manometry and biopsies. Prog Pediatr Surg. 24:202-16, 1989
                                                                          7. Hall SL et al: Neonatal intussusception associated with neonatal small left colon syndrome. Clin Pediatr (Phila). 26(4):191-3, 1987
                                                                          8. Amodio J et al: Microcolon of prematurity: a form of functional obstruction. AJR Am J Roentgenol. 146(2):239-44, 1986
                                                                          9. Ellerbroek C et al: Neonatal small left colon in an infant with cystic fibrosis. Pediatr Radiol. 16(2):162-3, 1986
                                                                          10. Johnson JF et al: Localized bowel distension in the newborn: a review of the plain film analysis and differential diagnosis. Pediatrics. 73(2):206-15, 1984
                                                                          11. Rosenfield NS et al: Hirschsprung disease: accuracy of the barium enema examination. Radiology. 150(2):393-400, 1984
                                                                          12. Cohen MD et al: Neonatal small left colon syndrome in twins. Gastrointest Radiol. 7(3):283-6, 1982
                                                                          13. Dunn V et al: Infants of diabetic mothers: radiographic manifestations. AJR Am J Roentgenol. 137(1):123-8, 1981
                                                                          14. Rangecroft L: Neonatal small left colon syndrome. Arch Dis Child. 54(8):635-7, 1979
                                                                          15. Berdon WE et al: Neonatal small left colon syndrome: its relationship to aganglionosis and meconium plug syndrome. Radiology. 125(2):457-62, 1977
                                                                          16. Ferrara TP et al: The radiology corner. Neonatal small left colon syndrome. Am J Gastroenterol. 68(6):608-12, 1977
                                                                          17. Stewart DR et al: Neonatal small left colon syndrome. Ann Surg. 186(6):741-5, 1977
                                                                          18. Davis WS et al: Neonatal small left colon syndrome. Occurrence in asymptomatic infants of diabetic mothers. Am J Dis Child. 129(9):1024-7, 1975
                                                                          19. Davis WS et al: Neonatal small left colon syndrome. Am J Roentgenol Radium Ther Nucl Med. 120(2):322-9, 1974
                                                                          20. Berdon WE et al: Microcolon in newborn infants with intestinal obstruction. Its correlation with the level and time of onset of obstruction. Radiology. 90(5):878-85, 1968