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Mediastinal Hodgkin Lymphoma
Santiago Martínez-Jiménez, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Formerly known as Hodgkin disease
            • Definitions

              • Lymphoid neoplasm arising from germinal center or postgerminal center B cells

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • Staging, Grading, & Classification

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Barrington SF et al: Role of imaging in the staging and response assessment of lymphoma: consensus of the International Conference on Malignant Lymphomas Imaging Working Group. J Clin Oncol. 32(27):3048-58, 2014
                                      2. Cheson BD et al: Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 32(27):3059-68, 2014
                                      3. Moccia AA et al: International Prognostic Score in advanced-stage Hodgkin's lymphoma: altered utility in the modern era. J Clin Oncol. 30(27):3383-8, 2012
                                      4. Das P et al: ACR Appropriateness Criteria® on Hodgkin's lymphoma-unfavorable clinical stage I and II. J Am Coll Radiol. 8(5):302-8, 2011
                                      5. Cronin CG et al: Clinical utility of PET/CT in lymphoma. AJR Am J Roentgenol. 194(1):W91-W103, 2010
                                      6. Burton C et al: The role of PET imaging in lymphoma. Br J Haematol. 126(6):772-84, 2004
                                      7. Israel O et al: Positron emission tomography in the evaluation of lymphoma. Semin Nucl Med. 34(3):166-79, 2004
                                      8. Gambhir SS et al: A tabulated summary of the FDG PET literature. J Nucl Med. 42(5 Suppl):1S-93S, 2001
                                      9. Bradley AJ et al: Assessment and significance of mediastinal bulk in Hodgkin's disease: comparison between computed tomography and chest radiography. J Clin Oncol. 17(8):2493-8, 1999
                                      10. Hasenclever D et al: A prognostic score for advanced Hodgkin's disease. International Prognostic Factors Project on Advanced Hodgkin's Disease. N Engl J Med. 339(21):1506-14, 1998
                                      11. Au V et al: Radiologic manifestations of lymphoma in the thorax. AJR Am J Roentgenol. 168(1):93-8, 1997
                                      12. Cosset JM et al: The EORTC trials for limited stage Hodgkin's disease. The EORTC Lymphoma Cooperative Group. Eur J Cancer. 28A(11):1847-50, 1992
                                      13. Hopper KD et al: Mediastinal bulk in Hodgkin disease. Method of measurement versus prognosis. Invest Radiol. 26(12):1101-10, 1991
                                      14. Hopper KD et al: The significance of necrotic mediastinal lymph nodes on CT in patients with newly diagnosed Hodgkin disease. AJR Am J Roentgenol. 155(2):267-70, 1990
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Synonyms

                                                  • Formerly known as Hodgkin disease
                                                • Definitions

                                                  • Lymphoid neoplasm arising from germinal center or postgerminal center B cells

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Nuclear Medicine Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • Staging, Grading, & Classification

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Barrington SF et al: Role of imaging in the staging and response assessment of lymphoma: consensus of the International Conference on Malignant Lymphomas Imaging Working Group. J Clin Oncol. 32(27):3048-58, 2014
                                                                          2. Cheson BD et al: Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 32(27):3059-68, 2014
                                                                          3. Moccia AA et al: International Prognostic Score in advanced-stage Hodgkin's lymphoma: altered utility in the modern era. J Clin Oncol. 30(27):3383-8, 2012
                                                                          4. Das P et al: ACR Appropriateness Criteria® on Hodgkin's lymphoma-unfavorable clinical stage I and II. J Am Coll Radiol. 8(5):302-8, 2011
                                                                          5. Cronin CG et al: Clinical utility of PET/CT in lymphoma. AJR Am J Roentgenol. 194(1):W91-W103, 2010
                                                                          6. Burton C et al: The role of PET imaging in lymphoma. Br J Haematol. 126(6):772-84, 2004
                                                                          7. Israel O et al: Positron emission tomography in the evaluation of lymphoma. Semin Nucl Med. 34(3):166-79, 2004
                                                                          8. Gambhir SS et al: A tabulated summary of the FDG PET literature. J Nucl Med. 42(5 Suppl):1S-93S, 2001
                                                                          9. Bradley AJ et al: Assessment and significance of mediastinal bulk in Hodgkin's disease: comparison between computed tomography and chest radiography. J Clin Oncol. 17(8):2493-8, 1999
                                                                          10. Hasenclever D et al: A prognostic score for advanced Hodgkin's disease. International Prognostic Factors Project on Advanced Hodgkin's Disease. N Engl J Med. 339(21):1506-14, 1998
                                                                          11. Au V et al: Radiologic manifestations of lymphoma in the thorax. AJR Am J Roentgenol. 168(1):93-8, 1997
                                                                          12. Cosset JM et al: The EORTC trials for limited stage Hodgkin's disease. The EORTC Lymphoma Cooperative Group. Eur J Cancer. 28A(11):1847-50, 1992
                                                                          13. Hopper KD et al: Mediastinal bulk in Hodgkin disease. Method of measurement versus prognosis. Invest Radiol. 26(12):1101-10, 1991
                                                                          14. Hopper KD et al: The significance of necrotic mediastinal lymph nodes on CT in patients with newly diagnosed Hodgkin disease. AJR Am J Roentgenol. 155(2):267-70, 1990