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Mediastinal Lymphoma
Sherief H. Garrana, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Non-Hodgkin lymphoma (NHL)
                • Hodgkin lymphoma (HL)
              • Synonyms

                • Primary mediastinal lymphoma
              • Definitions

                • Lymphoma arising primarily within or secondarily involving mediastinum
                • Primary mediastinal lymphomas
                  • Rare, comprise approximately 1% of all lymphomas; most common primary mediastinal malignancies

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Ultrasonographic Findings

                        • Nuclear Medicine Findings

                          • Imaging Recommendations

                            DIFFERENTIAL DIAGNOSIS

                              PATHOLOGY

                              • General Features

                                • Staging, Grading, & Classification

                                  • Gross Pathologic & Surgical Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                • Reporting Tips

                                                  Selected References

                                                  1. Pfau D et al: Primary Mediastinal large B-cell lymphoma: a review for radiologists. AJR Am J Roentgenol. 213(5):W194-210, 2019
                                                  2. Ceriani L et al: Positron emission tomography/computed tomography assessment after immunochemotherapy and irradiation using the Lugano classification criteria in the IELSG-26 study of primary mediastinal B-cell lymphoma. Int J Radiat Oncol Biol Phys. 97(1):42-9, 2017
                                                  3. Kligerman SJ et al: Primary extranodal lymphoma of the thorax. Radiol Clin North Am. 54(4):673-87, 2016
                                                  4. Verma A et al: Mediastinal gray zone lymphoma: a wider category than we think? Int J Surg Pathol. 24(5):382-93, 2016
                                                  5. Zinzani PL et al: Optimizing outcomes in primary mediastinal B-cell lymphoma. Hematol Oncol Clin North Am. 30(6):1261-75, 2016
                                                  6. Carter BW et al: Multimodality imaging of cardiothoracic lymphoma. Eur J Radiol. 83(8):1470-82, 2014
                                                  Related Anatomy
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                                                  Related Differential Diagnoses
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                                                  References
                                                  Tables

                                                  Tables

                                                  KEY FACTS

                                                  • Terminology

                                                    • Imaging

                                                      • Top Differential Diagnoses

                                                        • Pathology

                                                          • Clinical Issues

                                                            • Diagnostic Checklist

                                                              TERMINOLOGY

                                                              • Abbreviations

                                                                • Non-Hodgkin lymphoma (NHL)
                                                                • Hodgkin lymphoma (HL)
                                                              • Synonyms

                                                                • Primary mediastinal lymphoma
                                                              • Definitions

                                                                • Lymphoma arising primarily within or secondarily involving mediastinum
                                                                • Primary mediastinal lymphomas
                                                                  • Rare, comprise approximately 1% of all lymphomas; most common primary mediastinal malignancies

                                                              IMAGING

                                                              • General Features

                                                                • Radiographic Findings

                                                                  • CT Findings

                                                                    • MR Findings

                                                                      • Ultrasonographic Findings

                                                                        • Nuclear Medicine Findings

                                                                          • Imaging Recommendations

                                                                            DIFFERENTIAL DIAGNOSIS

                                                                              PATHOLOGY

                                                                              • General Features

                                                                                • Staging, Grading, & Classification

                                                                                  • Gross Pathologic & Surgical Features

                                                                                    CLINICAL ISSUES

                                                                                    • Presentation

                                                                                      • Demographics

                                                                                        • Natural History & Prognosis

                                                                                          • Treatment

                                                                                            DIAGNOSTIC CHECKLIST

                                                                                            • Consider

                                                                                              • Image Interpretation Pearls

                                                                                                • Reporting Tips

                                                                                                  Selected References

                                                                                                  1. Pfau D et al: Primary Mediastinal large B-cell lymphoma: a review for radiologists. AJR Am J Roentgenol. 213(5):W194-210, 2019
                                                                                                  2. Ceriani L et al: Positron emission tomography/computed tomography assessment after immunochemotherapy and irradiation using the Lugano classification criteria in the IELSG-26 study of primary mediastinal B-cell lymphoma. Int J Radiat Oncol Biol Phys. 97(1):42-9, 2017
                                                                                                  3. Kligerman SJ et al: Primary extranodal lymphoma of the thorax. Radiol Clin North Am. 54(4):673-87, 2016
                                                                                                  4. Verma A et al: Mediastinal gray zone lymphoma: a wider category than we think? Int J Surg Pathol. 24(5):382-93, 2016
                                                                                                  5. Zinzani PL et al: Optimizing outcomes in primary mediastinal B-cell lymphoma. Hematol Oncol Clin North Am. 30(6):1261-75, 2016
                                                                                                  6. Carter BW et al: Multimodality imaging of cardiothoracic lymphoma. Eur J Radiol. 83(8):1470-82, 2014