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Medullary Carcinoma
Kevin Kalisz, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • 7th sickle cell nephropathy
              • Definitions

                • Rare, aggressive tumor arising from renal papilla or calyceal epithelium of renal medulla
              • Associated Syndromes

                • Sickle cell trait (not sickle cell disease)

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          Selected References

                                          1. Sweet DE et al: Infiltrative renal malignancies: imaging features, prognostic implications, and mimics. Radiographics. 41(2):487-508, 2021
                                          2. Alvarez O et al: Renal medullary carcinoma and sickle cell trait: a systematic review. Pediatr Blood Cancer. 62(10):1694-9, 2015
                                          3. Shetty A et al: Renal medullary carcinoma: a case report and brief review of the literature. Ochsner J. 14(2):270-5, 2014
                                          4. Alappan N et al: Renal medullary cancer in a patient with sickle cell trait. Case Rep Oncol Med. 2013:129813, 2013
                                          5. Blitman NM et al: Renal medullary carcinoma: CT and MRI features. AJR Am J Roentgenol. 185(1):268-72, 2005
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Synonyms

                                                        • 7th sickle cell nephropathy
                                                      • Definitions

                                                        • Rare, aggressive tumor arising from renal papilla or calyceal epithelium of renal medulla
                                                      • Associated Syndromes

                                                        • Sickle cell trait (not sickle cell disease)

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Ultrasonographic Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  Selected References

                                                                                  1. Sweet DE et al: Infiltrative renal malignancies: imaging features, prognostic implications, and mimics. Radiographics. 41(2):487-508, 2021
                                                                                  2. Alvarez O et al: Renal medullary carcinoma and sickle cell trait: a systematic review. Pediatr Blood Cancer. 62(10):1694-9, 2015
                                                                                  3. Shetty A et al: Renal medullary carcinoma: a case report and brief review of the literature. Ochsner J. 14(2):270-5, 2014
                                                                                  4. Alappan N et al: Renal medullary cancer in a patient with sickle cell trait. Case Rep Oncol Med. 2013:129813, 2013
                                                                                  5. Blitman NM et al: Renal medullary carcinoma: CT and MRI features. AJR Am J Roentgenol. 185(1):268-72, 2005