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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Medulloblastoma (MB)
Synonyms
- Previously referred to as posterior fossa primitive neuroectodermal tumor (PNET), PNET-MB
- MB histologically similar to PNET but biologically distinct
- MB distinguished from PNET by i17q, loss of 17p, alterations of sonic hedgehog (SHH) and wingless (Wnt) pathways, pattern of DNA methylation
- Previously referred to as posterior fossa primitive neuroectodermal tumor (PNET), PNET-MB
Definitions
- Malignant (WHO grade IV), invasive, highly cellular embryonal tumor
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Cassia GSE et al: Childhood medulloblastoma revisited. Top Magn Reson Imaging. 27(6):479-502, 2018
- Shih RY et al: Embryonal tumors of the central nervous system: from the radiologic pathology archives. Radiographics. 38(2):525-41, 2018
- Schwalbe EC et al: Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study. Lancet Oncol. 18(7):958-71, 2017
- Raybaud C et al: Posterior fossa tumors in children: developmental anatomy and diagnostic imaging. Childs Nerv Syst. 31(10):1661-76, 2015
- Wong TT et al: Factors affecting survival of medulloblastoma in children: the changing concept of management. Childs Nerv Syst. 31(10):1687-98, 2015
- Ostrom QT et al: CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. Neuro Oncol. 16 Suppl 4:iv1-63, 2014
- Perreault S et al: MRI surrogates for molecular subgroups of medulloblastoma. AJNR Am J Neuroradiol. 35(7):1263-9, 2014
- Pierce TT et al: Evaluation of apparent diffusion coefficient thresholds for diagnosis of medulloblastoma using diffusion-weighted imaging. Neuroradiol J. 27(1):63-74, 2014
- Pierce T et al: Use of apparent diffusion coefficient values for diagnosis of pediatric posterior fossa tumors. Neuroradiol J. 27(2):233-44, 2014
- Plaza MJ et al: Conventional and advanced MRI features of pediatric intracranial tumors: posterior fossa and suprasellar tumors. AJR Am J Roentgenol. 200(5):1115-24, 2013
- Yeom KW et al: Distinctive MRI features of pediatric medulloblastoma subtypes. AJR Am J Roentgenol. 200(4):895-903, 2013
- Poretti A et al: Neuroimaging of pediatric posterior fossa tumors including review of the literature. J Magn Reson Imaging. 35(1):32-47, 2012
- Craver R et al: Medulloblastoma variants and survival at a children's hospital. Fetal Pediatr Pathol. 30(1):53-9, 2011
- Eran A et al: Medulloblastoma: atypical CT and MRI findings in children. Pediatr Radiol. 40(7):1254-62, 2010
- Jaremko JL et al: Value and limitations of diffusion-weighted imaging in grading and diagnosis of pediatric posterior fossa tumors. AJNR Am J Neuroradiol. 2010 Oct;31(9):1613-6. Epub 2010 Jun 10. Erratum in: AJNR Am J Neuroradiol. 31(10):E90, 2010
- Louis DN et al: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114(2):97-109, 2007
- Gururangan S et al: [18F]Fluorodeoxyglucose-positron emission tomography in patients with medulloblastoma. Neurosurgery. 55(6):1280-9, 2004
- Koeller KK et al: From the archives of the AFIP: medulloblastoma: a comprehensive review with radiologic-pathologic correlation. Radiographics. 23(6):1613-37, 2003
- Meyers SP et al: Postoperative evaluation for disseminated medulloblastoma involving the spine: contrast-enhanced MR findings, CSF cytologic analysis, timing of disease occurrence, and patient outcomes. AJNR Am J Neuroradiol. 21(9):1757-65, 2000
- Tortori-Donati P et al: Medulloblastoma in children: CT and MRI findings. Neuroradiology. 38(4):352-9, 1996
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Medulloblastoma (MB)
Synonyms
- Previously referred to as posterior fossa primitive neuroectodermal tumor (PNET), PNET-MB
- MB histologically similar to PNET but biologically distinct
- MB distinguished from PNET by i17q, loss of 17p, alterations of sonic hedgehog (SHH) and wingless (Wnt) pathways, pattern of DNA methylation
- Previously referred to as posterior fossa primitive neuroectodermal tumor (PNET), PNET-MB
Definitions
- Malignant (WHO grade IV), invasive, highly cellular embryonal tumor
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Cassia GSE et al: Childhood medulloblastoma revisited. Top Magn Reson Imaging. 27(6):479-502, 2018
- Shih RY et al: Embryonal tumors of the central nervous system: from the radiologic pathology archives. Radiographics. 38(2):525-41, 2018
- Schwalbe EC et al: Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study. Lancet Oncol. 18(7):958-71, 2017
- Raybaud C et al: Posterior fossa tumors in children: developmental anatomy and diagnostic imaging. Childs Nerv Syst. 31(10):1661-76, 2015
- Wong TT et al: Factors affecting survival of medulloblastoma in children: the changing concept of management. Childs Nerv Syst. 31(10):1687-98, 2015
- Ostrom QT et al: CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. Neuro Oncol. 16 Suppl 4:iv1-63, 2014
- Perreault S et al: MRI surrogates for molecular subgroups of medulloblastoma. AJNR Am J Neuroradiol. 35(7):1263-9, 2014
- Pierce TT et al: Evaluation of apparent diffusion coefficient thresholds for diagnosis of medulloblastoma using diffusion-weighted imaging. Neuroradiol J. 27(1):63-74, 2014
- Pierce T et al: Use of apparent diffusion coefficient values for diagnosis of pediatric posterior fossa tumors. Neuroradiol J. 27(2):233-44, 2014
- Plaza MJ et al: Conventional and advanced MRI features of pediatric intracranial tumors: posterior fossa and suprasellar tumors. AJR Am J Roentgenol. 200(5):1115-24, 2013
- Yeom KW et al: Distinctive MRI features of pediatric medulloblastoma subtypes. AJR Am J Roentgenol. 200(4):895-903, 2013
- Poretti A et al: Neuroimaging of pediatric posterior fossa tumors including review of the literature. J Magn Reson Imaging. 35(1):32-47, 2012
- Craver R et al: Medulloblastoma variants and survival at a children's hospital. Fetal Pediatr Pathol. 30(1):53-9, 2011
- Eran A et al: Medulloblastoma: atypical CT and MRI findings in children. Pediatr Radiol. 40(7):1254-62, 2010
- Jaremko JL et al: Value and limitations of diffusion-weighted imaging in grading and diagnosis of pediatric posterior fossa tumors. AJNR Am J Neuroradiol. 2010 Oct;31(9):1613-6. Epub 2010 Jun 10. Erratum in: AJNR Am J Neuroradiol. 31(10):E90, 2010
- Louis DN et al: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114(2):97-109, 2007
- Gururangan S et al: [18F]Fluorodeoxyglucose-positron emission tomography in patients with medulloblastoma. Neurosurgery. 55(6):1280-9, 2004
- Koeller KK et al: From the archives of the AFIP: medulloblastoma: a comprehensive review with radiologic-pathologic correlation. Radiographics. 23(6):1613-37, 2003
- Meyers SP et al: Postoperative evaluation for disseminated medulloblastoma involving the spine: contrast-enhanced MR findings, CSF cytologic analysis, timing of disease occurrence, and patient outcomes. AJNR Am J Neuroradiol. 21(9):1757-65, 2000
- Tortori-Donati P et al: Medulloblastoma in children: CT and MRI findings. Neuroradiology. 38(4):352-9, 1996
