Van Ommeren R et al: The molecular biology of medulloblastoma metastasis. Brain Pathol. 30(3):691-702, 2020
Zou H et al: Molecular heterogeneity and cellular diversity: implications for precision treatment in medulloblastoma. Cancers (Basel). 12(3):643, 2020
Stock A et al: Imaging characteristics of wingless pathway subgroup medulloblastomas: Results from the German HIT/SIOP-trial cohort. AJNR Am J Neuroradiol. 40(11):1811-7, 2019
Related Anatomy
Loading...
Related Differential Diagnoses
Loading...
References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Medulloblastoma (MB), brain tumor (BT)
Definitions
Most common malignant BT in children
2nd overall to leukemia but much worse overall prognosis
Malignant, invasive, highly cellular embryonal tumor of cerebellum
Not single-disease entity
Group of tumors with variable locations, molecular features, risk stratification, patterns of recurrence, outcome
4 distinct MB subgroups defined by methylome or gene expression profiling
Wingless (WNT) activated
Sonic hedgehog (SHH) activated
Group 3 (Grp3)
Group 4 (Grp4)
Each subgroup also has additional subtypes
Subtyping permits more granular view of outcome, dissemination risk profiles
12 unique subtypes, each with distinctive molecular and clinical characteristics
Subgroup affiliation maintained in relapse/recurrence
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Angiographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Bhattacharya D et al: Epigenetics and survivorship in pediatric brain tumor patients. J Neurooncol. ePub, 2020
Blessing MM et al: Embryonal tumors of the central nervous system: an update. Surg Pathol Clin. 13(2):235-47, 2020
Cacciotti C et al: Advances in the molecular classification of pediatric brain tumors: a guide to the galaxy. J Pathol. ePub, 2020
Dong J et al: Differentiation between ependymoma and medulloblastoma in children with radiomics approach. Acad Radiol. ePub, 2020
Hovestadt V et al: Medulloblastomics revisited: biological and clinical insights from thousands of patients. Nat Rev Cancer. 20(1):42-56, 2020
Kumar R et al: Medulloblastoma genomics in the modern molecular era. Brain Pathol. 30(3):679-90, 2020
Malbari F et al: Genetics of common pediatric brain tumors. Pediatr Neurol. 104:3-12, 2020
Van Ommeren R et al: The molecular biology of medulloblastoma metastasis. Brain Pathol. 30(3):691-702, 2020
Zou H et al: Molecular heterogeneity and cellular diversity: implications for precision treatment in medulloblastoma. Cancers (Basel). 12(3):643, 2020
Stock A et al: Imaging characteristics of wingless pathway subgroup medulloblastomas: Results from the German HIT/SIOP-trial cohort. AJNR Am J Neuroradiol. 40(11):1811-7, 2019
STATdx includes over 200,000 searchable images, including x-ray, CT, MR, and ultrasound images. To access all images, please log in or subscribe.