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Melanotic Neuroectodermal Tumors
Surjith Vattoth, MD, FRCR; Caroline D. Robson, MBChB
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Melanotic neuroectodermal tumor of infancy (MNTI)
            • Synonyms

              • Melanotic progonoma, melanin-containing primitive neuroectodermal tumor, retinal anlage tumor
            • Definitions

              • Rare, locally aggressive pigmented tumor of infancy
              • Do not confuse with neurocutaneous melanosis

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • Gross Pathologic & Surgical Features

                        CLINICAL ISSUES

                        • Presentation

                          • Demographics

                            • Natural History & Prognosis

                              • Treatment

                                Selected References

                                1. Jakchairoongruang K et al: New insights into neurocutaneous melanosis. Pediatr Radiol. 48(12):1786-96, 2018
                                2. Moreau A et al: Melanotic neuroectodermal tumor of infancy (MNTI) of the head and neck: a French multicenter study. J Craniomaxillofac Surg. 46(2):201-6, 2018
                                3. Yoo IH et al: Melanotic neuroectodermal tumor of infancy disseminated by a ventriculoperitoneal shunt and diagnosed from the inguinal sac. J Pediatr Hematol Oncol. 36(1):e61-4, 2014
                                4. Naidoo J et al: Melanotic neuroectodermal tumour of infancy, a rare cause for a bump on the head. Childs Nerv Syst. 29(1):167-72, 2013
                                5. Furtado SV et al: Calvarial malignant melanotic neuroectodermal tumour of infancy presenting with widespread intracranial metastasis. J Craniomaxillofac Surg. 40(6):e170-3, 2012
                                6. Haque S et al: Melanotic neuroectodermal tumour of infancy: CT and MR findings. Pediatr Radiol. 42(6):699-705, 2012
                                7. Manojlović S et al: Melanotic neuroectodermal tumour of infancy: report of two cases and review of the literature. J Craniomaxillofac Surg. 40(4):e103-7, 2012
                                8. Saleem S et al: Melanotic neuroectodermal tumor of the calvarium. Pediatr Radiol. 40 Suppl 1:S159, 2010
                                9. Chaudhary A et al: Melanotic neuroectodermal tumor of infancy: 2 decades of clinical experience with 18 patients. J Oral Maxillofac Surg. 67(1):47-51, 2009
                                10. Kantar M et al: Melanotic progonoma of the skull in infancy. Childs Nerv Syst. 24(11):1371-5, 2008
                                11. Kumari TP et al: Effectiveness of chemotherapy in melanotic neurectodermal tumor of infancy. Pediatr Hematol Oncol. 22(3):199-206, 2005
                                12. Rickert CH et al: Melanotic progonoma of the brain: a case report and review. Childs Nerv Syst. 14(8):389-93, 1998
                                13. Williams AO: Melanotic ameloblastoma ("progonoma") of infancy showing osteogenesis. J Pathol Bacteriol. 93(2):545-8, 1967
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Pathology

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Melanotic neuroectodermal tumor of infancy (MNTI)
                                          • Synonyms

                                            • Melanotic progonoma, melanin-containing primitive neuroectodermal tumor, retinal anlage tumor
                                          • Definitions

                                            • Rare, locally aggressive pigmented tumor of infancy
                                            • Do not confuse with neurocutaneous melanosis

                                          IMAGING

                                          • General Features

                                            • CT Findings

                                              • MR Findings

                                                • Imaging Recommendations

                                                  DIFFERENTIAL DIAGNOSIS

                                                    PATHOLOGY

                                                    • Gross Pathologic & Surgical Features

                                                      CLINICAL ISSUES

                                                      • Presentation

                                                        • Demographics

                                                          • Natural History & Prognosis

                                                            • Treatment

                                                              Selected References

                                                              1. Jakchairoongruang K et al: New insights into neurocutaneous melanosis. Pediatr Radiol. 48(12):1786-96, 2018
                                                              2. Moreau A et al: Melanotic neuroectodermal tumor of infancy (MNTI) of the head and neck: a French multicenter study. J Craniomaxillofac Surg. 46(2):201-6, 2018
                                                              3. Yoo IH et al: Melanotic neuroectodermal tumor of infancy disseminated by a ventriculoperitoneal shunt and diagnosed from the inguinal sac. J Pediatr Hematol Oncol. 36(1):e61-4, 2014
                                                              4. Naidoo J et al: Melanotic neuroectodermal tumour of infancy, a rare cause for a bump on the head. Childs Nerv Syst. 29(1):167-72, 2013
                                                              5. Furtado SV et al: Calvarial malignant melanotic neuroectodermal tumour of infancy presenting with widespread intracranial metastasis. J Craniomaxillofac Surg. 40(6):e170-3, 2012
                                                              6. Haque S et al: Melanotic neuroectodermal tumour of infancy: CT and MR findings. Pediatr Radiol. 42(6):699-705, 2012
                                                              7. Manojlović S et al: Melanotic neuroectodermal tumour of infancy: report of two cases and review of the literature. J Craniomaxillofac Surg. 40(4):e103-7, 2012
                                                              8. Saleem S et al: Melanotic neuroectodermal tumor of the calvarium. Pediatr Radiol. 40 Suppl 1:S159, 2010
                                                              9. Chaudhary A et al: Melanotic neuroectodermal tumor of infancy: 2 decades of clinical experience with 18 patients. J Oral Maxillofac Surg. 67(1):47-51, 2009
                                                              10. Kantar M et al: Melanotic progonoma of the skull in infancy. Childs Nerv Syst. 24(11):1371-5, 2008
                                                              11. Kumari TP et al: Effectiveness of chemotherapy in melanotic neurectodermal tumor of infancy. Pediatr Hematol Oncol. 22(3):199-206, 2005
                                                              12. Rickert CH et al: Melanotic progonoma of the brain: a case report and review. Childs Nerv Syst. 14(8):389-93, 1998
                                                              13. Williams AO: Melanotic ameloblastoma ("progonoma") of infancy showing osteogenesis. J Pathol Bacteriol. 93(2):545-8, 1967