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Melanotic Schwannoma
Jeffrey S. Ross, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Psammomatous melanotic schwannoma
                • Malignant melanotic schwannian tumor (proposed)
              • Definitions

                • Unusual Schwann cell neoplasm containing variable melanin pigment and showing potential for malignant behavior

              IMAGING

              • General Features

                • MR Findings

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Gross Pathologic & Surgical Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    Selected References

                                    1. Koeller KK et al: Intradural extramedullary spinal neoplasms: radiologic-pathologic correlation. radiographics. 39(2):468-90, 2019
                                    2. Chandran RS et al: Melanotic schwannoma of spine: illustration of two cases with diverse clinical presentation and outcome. Asian J Neurosurg. 13(3):881-4, 2018
                                    3. Bakan S et al: Primary psammomatous melanotic schwannoma of the spine. Ann Thorac Surg. 99(6):e141-3, 2015
                                    4. Torres-Mora J et al: Malignant melanotic schwannian tumor: a clinicopathologic, immunohistochemical, and gene expression profiling study of 40 cases, with a proposal for the reclassification of "melanotic schwannoma". Am J Surg Pathol. 38(1):94-105, 2014
                                    5. Carney JA: Psammomatous melanotic schwannoma. A distinctive, heritable tumor with special associations, including cardiac myxoma and the Cushing syndrome. Am J Surg Pathol. 14(3):206-22, 1990
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Pathology

                                            • Clinical Issues

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Synonyms

                                                  • Psammomatous melanotic schwannoma
                                                  • Malignant melanotic schwannian tumor (proposed)
                                                • Definitions

                                                  • Unusual Schwann cell neoplasm containing variable melanin pigment and showing potential for malignant behavior

                                                IMAGING

                                                • General Features

                                                  • MR Findings

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        • Gross Pathologic & Surgical Features

                                                          • Microscopic Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Consider

                                                                      Selected References

                                                                      1. Koeller KK et al: Intradural extramedullary spinal neoplasms: radiologic-pathologic correlation. radiographics. 39(2):468-90, 2019
                                                                      2. Chandran RS et al: Melanotic schwannoma of spine: illustration of two cases with diverse clinical presentation and outcome. Asian J Neurosurg. 13(3):881-4, 2018
                                                                      3. Bakan S et al: Primary psammomatous melanotic schwannoma of the spine. Ann Thorac Surg. 99(6):e141-3, 2015
                                                                      4. Torres-Mora J et al: Malignant melanotic schwannian tumor: a clinicopathologic, immunohistochemical, and gene expression profiling study of 40 cases, with a proposal for the reclassification of "melanotic schwannoma". Am J Surg Pathol. 38(1):94-105, 2014
                                                                      5. Carney JA: Psammomatous melanotic schwannoma. A distinctive, heritable tumor with special associations, including cardiac myxoma and the Cushing syndrome. Am J Surg Pathol. 14(3):206-22, 1990