Unusual Schwann cell neoplasm containing variable melanin pigment and showing potential for malignant behavior
IMAGING
General Features
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Koeller KK et al: Intradural extramedullary spinal neoplasms: radiologic-pathologic correlation. radiographics. 39(2):468-90, 2019
Chandran RS et al: Melanotic schwannoma of spine: illustration of two cases with diverse clinical presentation and outcome. Asian J Neurosurg. 13(3):881-4, 2018
Bakan S et al: Primary psammomatous melanotic schwannoma of the spine. Ann Thorac Surg. 99(6):e141-3, 2015
Torres-Mora J et al: Malignant melanotic schwannian tumor: a clinicopathologic, immunohistochemical, and gene expression profiling study of 40 cases, with a proposal for the reclassification of "melanotic schwannoma". Am J Surg Pathol. 38(1):94-105, 2014
Carney JA: Psammomatous melanotic schwannoma. A distinctive, heritable tumor with special associations, including cardiac myxoma and the Cushing syndrome. Am J Surg Pathol. 14(3):206-22, 1990
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References
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
Psammomatous melanotic schwannoma
Malignant melanotic schwannian tumor (proposed)
Definitions
Unusual Schwann cell neoplasm containing variable melanin pigment and showing potential for malignant behavior
IMAGING
General Features
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Koeller KK et al: Intradural extramedullary spinal neoplasms: radiologic-pathologic correlation. radiographics. 39(2):468-90, 2019
Chandran RS et al: Melanotic schwannoma of spine: illustration of two cases with diverse clinical presentation and outcome. Asian J Neurosurg. 13(3):881-4, 2018
Bakan S et al: Primary psammomatous melanotic schwannoma of the spine. Ann Thorac Surg. 99(6):e141-3, 2015
Torres-Mora J et al: Malignant melanotic schwannian tumor: a clinicopathologic, immunohistochemical, and gene expression profiling study of 40 cases, with a proposal for the reclassification of "melanotic schwannoma". Am J Surg Pathol. 38(1):94-105, 2014
Carney JA: Psammomatous melanotic schwannoma. A distinctive, heritable tumor with special associations, including cardiac myxoma and the Cushing syndrome. Am J Surg Pathol. 14(3):206-22, 1990
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