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Mesenchymal Hamartoma
Paula J. Woodward, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Definitions

                • Benign liver tumor composed of large, fluid-filled cysts surrounded by loose mesenchymal tissue

              IMAGING

              • General Features

                • Ultrasonographic Findings

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Harris K et al: Placental mesenchymal dysplasia with hepatic mesenchymal hamartoma: a case report and literature review. Fetal Pediatr Pathol. 32(6):448-53, 2013
                                        2. Mack-Detlefsen B et al: Multiple hepatic mesenchymal hamartomas in a premature associated with placental mesenchymal dysplasia. J Pediatr Surg. 46(8):e23-5, 2011
                                        3. Makin E et al: Fetal and neonatal liver tumours. Early Hum Dev. 86(10):637-42, 2010
                                        4. Cornette J et al: Mesenchymal hamartoma of the liver: a benign tumor with deceptive prognosis in the perinatal period. Case report and review of the literature. Fetal Diagn Ther. 25(2):196-202, 2009
                                        5. Cajaiba MM et al: Mesenchymal hamartoma of the liver associated with features of Beckwith-Wiedemann syndrome and high serum alpha-fetoprotein levels. Pediatr Dev Pathol. 10(3):233-8, 2007
                                        6. Isaacs H Jr: Fetal and neonatal hepatic tumors. J Pediatr Surg. 42(11):1797-803, 2007
                                        7. Siddiqui MA et al: Hepatic mesenchymal hamartoma: a short review. Arch Pathol Lab Med. 130(10):1567-9, 2006
                                        8. Laberge JM et al: Large hepatic mesenchymal hamartoma leading to mid-trimester fetal demise. Fetal Diagn Ther. 20(2):141-5, 2005
                                        9. Woodward PJ et al: From the archives of the AFIP: a comprehensive review of fetal tumors with pathologic correlation. Radiographics. 25(1):215-42, 2005
                                        10. Kamata S et al: Fetal mesenchymal hamartoma of the liver: report of a case. J Pediatr Surg. 38(4):639-41, 2003
                                        11. Kitano Y et al: Hepatic mesenchymal hamartoma associated with mesenchymal stem villous hyperplasia of the placenta. Fetal Diagn Ther. 15(3):134-8, 2000
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Definitions

                                                      • Benign liver tumor composed of large, fluid-filled cysts surrounded by loose mesenchymal tissue

                                                    IMAGING

                                                    • General Features

                                                      • Ultrasonographic Findings

                                                        • MR Findings

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          DIAGNOSTIC CHECKLIST

                                                                          • Consider

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Harris K et al: Placental mesenchymal dysplasia with hepatic mesenchymal hamartoma: a case report and literature review. Fetal Pediatr Pathol. 32(6):448-53, 2013
                                                                              2. Mack-Detlefsen B et al: Multiple hepatic mesenchymal hamartomas in a premature associated with placental mesenchymal dysplasia. J Pediatr Surg. 46(8):e23-5, 2011
                                                                              3. Makin E et al: Fetal and neonatal liver tumours. Early Hum Dev. 86(10):637-42, 2010
                                                                              4. Cornette J et al: Mesenchymal hamartoma of the liver: a benign tumor with deceptive prognosis in the perinatal period. Case report and review of the literature. Fetal Diagn Ther. 25(2):196-202, 2009
                                                                              5. Cajaiba MM et al: Mesenchymal hamartoma of the liver associated with features of Beckwith-Wiedemann syndrome and high serum alpha-fetoprotein levels. Pediatr Dev Pathol. 10(3):233-8, 2007
                                                                              6. Isaacs H Jr: Fetal and neonatal hepatic tumors. J Pediatr Surg. 42(11):1797-803, 2007
                                                                              7. Siddiqui MA et al: Hepatic mesenchymal hamartoma: a short review. Arch Pathol Lab Med. 130(10):1567-9, 2006
                                                                              8. Laberge JM et al: Large hepatic mesenchymal hamartoma leading to mid-trimester fetal demise. Fetal Diagn Ther. 20(2):141-5, 2005
                                                                              9. Woodward PJ et al: From the archives of the AFIP: a comprehensive review of fetal tumors with pathologic correlation. Radiographics. 25(1):215-42, 2005
                                                                              10. Kamata S et al: Fetal mesenchymal hamartoma of the liver: report of a case. J Pediatr Surg. 38(4):639-41, 2003
                                                                              11. Kitano Y et al: Hepatic mesenchymal hamartoma associated with mesenchymal stem villous hyperplasia of the placenta. Fetal Diagn Ther. 15(3):134-8, 2000