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Mesenchymal Hamartoma
A. Carlson Merrow, Jr., MD, FAAP
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Definitions

              • Mesenchymal hamartoma (MH): Benign liver tumor of infants due to primitive mesenchymal proliferation

            IMAGING

            • General Features

              • Radiographic Findings

                • Ultrasonographic Findings

                  • CT Findings

                    • MR Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. Katzenstein HM et al: Neonatal liver tumors. Clin Perinatol. 48(1):83-99, 2021
                                        2. Meyers R et al: Liver tumors in pediatric patients. Surg Oncol Clin N Am. 30(2):253-74, 2021
                                        3. Vasireddi AK et al: Magnetic resonance imaging of pediatric liver tumors. Pediatr Radiol. ePub, 2021
                                        4. Martins-Filho SN et al: Hepatic mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver: a pathologic review. Hepat Oncol. 7(2):HEP19, 2020
                                        5. Pan ET et al: Liver transplantation as definitive treatment of an unresectable mesenchymal hamartoma in a child with Beckwith-Wiedemann syndrome. J Surg Case Rep. 2017(8):rjx167, 2017
                                        6. Saeed O et al: Primary mesenchymal liver tumors of childhood. Semin Diagn Pathol. 34(2):201-7, 2017
                                        7. Abrahao-Machado LF et al: Mesenchymal hamartoma of the liver in an infant with Beckwith-Wiedemann syndrome: a rare condition mimicking hepatoblastoma. ACG Case Rep J. 2(4):258-60, 2015
                                        8. Fernandez-Pineda I et al: Differential diagnosis and management of liver tumors in infants. World J Hepatol. 6(7):486-95, 2014
                                        9. Wildhaber BE et al: Mesenchymal hamartoma or embryonal sarcoma of the liver in childhood: a difficult diagnosis before complete surgical excision. J Pediatr Surg. 49(9):1372-7, 2014
                                        10. Bhargava P et al: Radiologic-pathologic correlation of uncommon mesenchymal liver tumors. Curr Probl Diagn Radiol. 42(5):183-90, 2013
                                        11. Harris K et al: Placental mesenchymal dysplasia with hepatic mesenchymal hamartoma: a case report and literature review. Fetal Pediatr Pathol. 32(6):448-53, 2013
                                        12. Adeyiga AO et al: Focal hepatic masses in pediatric patients. AJR Am J Roentgenol. 199(4):W422-40, 2012
                                        13. Ramareddy RS et al: Neonatal mesenchymal hamartoma of liver: an unusual presentation. J Clin Neonatol. 1(4):211-3, 2012
                                        14. Kodandapani S et al: Prenatal diagnosis of congenital mesenchymal hamartoma of liver: a case report. Case Rep Obstet Gynecol. 2011:932583, 2011
                                        15. Chung EM et al: From the archives of the AFIP: pediatric liver masses: radiologic-pathologic correlation. Part 1. Benign tumors. Radiographics. 30(3):801-26, 2010
                                        16. Makin E et al: Fetal and neonatal liver tumours. Early Hum Dev. 86(10):637-42, 2010
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Definitions

                                                    • Mesenchymal hamartoma (MH): Benign liver tumor of infants due to primitive mesenchymal proliferation

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • Ultrasonographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Gross Pathologic & Surgical Features

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. Katzenstein HM et al: Neonatal liver tumors. Clin Perinatol. 48(1):83-99, 2021
                                                                              2. Meyers R et al: Liver tumors in pediatric patients. Surg Oncol Clin N Am. 30(2):253-74, 2021
                                                                              3. Vasireddi AK et al: Magnetic resonance imaging of pediatric liver tumors. Pediatr Radiol. ePub, 2021
                                                                              4. Martins-Filho SN et al: Hepatic mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver: a pathologic review. Hepat Oncol. 7(2):HEP19, 2020
                                                                              5. Pan ET et al: Liver transplantation as definitive treatment of an unresectable mesenchymal hamartoma in a child with Beckwith-Wiedemann syndrome. J Surg Case Rep. 2017(8):rjx167, 2017
                                                                              6. Saeed O et al: Primary mesenchymal liver tumors of childhood. Semin Diagn Pathol. 34(2):201-7, 2017
                                                                              7. Abrahao-Machado LF et al: Mesenchymal hamartoma of the liver in an infant with Beckwith-Wiedemann syndrome: a rare condition mimicking hepatoblastoma. ACG Case Rep J. 2(4):258-60, 2015
                                                                              8. Fernandez-Pineda I et al: Differential diagnosis and management of liver tumors in infants. World J Hepatol. 6(7):486-95, 2014
                                                                              9. Wildhaber BE et al: Mesenchymal hamartoma or embryonal sarcoma of the liver in childhood: a difficult diagnosis before complete surgical excision. J Pediatr Surg. 49(9):1372-7, 2014
                                                                              10. Bhargava P et al: Radiologic-pathologic correlation of uncommon mesenchymal liver tumors. Curr Probl Diagn Radiol. 42(5):183-90, 2013
                                                                              11. Harris K et al: Placental mesenchymal dysplasia with hepatic mesenchymal hamartoma: a case report and literature review. Fetal Pediatr Pathol. 32(6):448-53, 2013
                                                                              12. Adeyiga AO et al: Focal hepatic masses in pediatric patients. AJR Am J Roentgenol. 199(4):W422-40, 2012
                                                                              13. Ramareddy RS et al: Neonatal mesenchymal hamartoma of liver: an unusual presentation. J Clin Neonatol. 1(4):211-3, 2012
                                                                              14. Kodandapani S et al: Prenatal diagnosis of congenital mesenchymal hamartoma of liver: a case report. Case Rep Obstet Gynecol. 2011:932583, 2011
                                                                              15. Chung EM et al: From the archives of the AFIP: pediatric liver masses: radiologic-pathologic correlation. Part 1. Benign tumors. Radiographics. 30(3):801-26, 2010
                                                                              16. Makin E et al: Fetal and neonatal liver tumours. Early Hum Dev. 86(10):637-42, 2010