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Mesoblastic Nephroma
A. Carlson Merrow, Jr., MD, FAAP
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Synonyms

              • Congenital mesoblastic nephroma (MN), fetal renal hamartoma, Bolande tumor
                • Bolande described MN as histologically distinct from Wilms tumor in 1967
            • Definitions

              • Hamartomatous renal tumor of young infants composed predominantly of elongated spindle cells
                • Classic benign MN vs. more aggressive cellular variant

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Malkan AD et al: An approach to renal masses in pediatrics. Pediatrics. 135(1):142-58, 2015
                                              2. Takahashi H et al: Congenital mesoblastic nephroma: Its diverse clinical features - A literature review with a case report. J Obstet Gynaecol. 1-5, 2015
                                              3. Wang ZP et al: Congenital mesoblastic nephroma: Clinical analysis of eight cases and a review of the literature. Oncol Lett. 8(5):2007-2011, 2014
                                              4. Ko SM et al: Cellular mesoblastic nephroma with liver metastasis in a neonate: prenatal and postnatal diffusion-weighted MR imaging. Korean J Radiol. 14(2):361-5, 2013
                                              5. Royer-Pokora B: Genetics of pediatric renal tumors. Pediatr Nephrol. 28(1):13-23, 2013
                                              6. Sheth MM et al: AIRP best cases in radiologic-pathologic correlation: congenital mesoblastic nephroma. Radiographics. 32(1):99-103, 2012
                                              7. England RJ et al: Mesoblastic nephroma: a report of the United Kingdom Children's Cancer and Leukaemia Group (CCLG). Pediatr Blood Cancer. 56(5):744-8, 2011
                                              8. Gruver AM et al: Congenital mesoblastic nephroma. J Urol. 183(3):1188-9, 2010
                                              9. Bayindir P et al: Cellular mesoblastic nephroma (infantile renal fibrosarcoma): institutional review of the clinical, diagnostic imaging, and pathologic features of a distinctive neoplasm of infancy. Pediatr Radiol. 39(10):1066-74, 2009
                                              10. Chaudry G et al: Imaging of congenital mesoblastic nephroma with pathological correlation. Pediatr Radiol. 39(10):1080-6, 2009
                                              11. Leclair MD et al: The outcome of prenatally diagnosed renal tumors. J Urol. 173(1):186-9, 2005
                                              12. Lee EY: CT imaging of mass-like renal lesions in children. Pediatr Radiol. 37(9):896-907, 2007
                                              13. Glick RD et al: Renal tumors in infants less than 6 months of age. J Pediatr Surg. 39(4):522-5, 2004
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Pathology

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Synonyms

                                                          • Congenital mesoblastic nephroma (MN), fetal renal hamartoma, Bolande tumor
                                                            • Bolande described MN as histologically distinct from Wilms tumor in 1967
                                                        • Definitions

                                                          • Hamartomatous renal tumor of young infants composed predominantly of elongated spindle cells
                                                            • Classic benign MN vs. more aggressive cellular variant

                                                        IMAGING

                                                        • General Features

                                                          • Radiographic Findings

                                                            • CT Findings

                                                              • MR Findings

                                                                • Ultrasonographic Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Malkan AD et al: An approach to renal masses in pediatrics. Pediatrics. 135(1):142-58, 2015
                                                                                          2. Takahashi H et al: Congenital mesoblastic nephroma: Its diverse clinical features - A literature review with a case report. J Obstet Gynaecol. 1-5, 2015
                                                                                          3. Wang ZP et al: Congenital mesoblastic nephroma: Clinical analysis of eight cases and a review of the literature. Oncol Lett. 8(5):2007-2011, 2014
                                                                                          4. Ko SM et al: Cellular mesoblastic nephroma with liver metastasis in a neonate: prenatal and postnatal diffusion-weighted MR imaging. Korean J Radiol. 14(2):361-5, 2013
                                                                                          5. Royer-Pokora B: Genetics of pediatric renal tumors. Pediatr Nephrol. 28(1):13-23, 2013
                                                                                          6. Sheth MM et al: AIRP best cases in radiologic-pathologic correlation: congenital mesoblastic nephroma. Radiographics. 32(1):99-103, 2012
                                                                                          7. England RJ et al: Mesoblastic nephroma: a report of the United Kingdom Children's Cancer and Leukaemia Group (CCLG). Pediatr Blood Cancer. 56(5):744-8, 2011
                                                                                          8. Gruver AM et al: Congenital mesoblastic nephroma. J Urol. 183(3):1188-9, 2010
                                                                                          9. Bayindir P et al: Cellular mesoblastic nephroma (infantile renal fibrosarcoma): institutional review of the clinical, diagnostic imaging, and pathologic features of a distinctive neoplasm of infancy. Pediatr Radiol. 39(10):1066-74, 2009
                                                                                          10. Chaudry G et al: Imaging of congenital mesoblastic nephroma with pathological correlation. Pediatr Radiol. 39(10):1080-6, 2009
                                                                                          11. Leclair MD et al: The outcome of prenatally diagnosed renal tumors. J Urol. 173(1):186-9, 2005
                                                                                          12. Lee EY: CT imaging of mass-like renal lesions in children. Pediatr Radiol. 37(9):896-907, 2007
                                                                                          13. Glick RD et al: Renal tumors in infants less than 6 months of age. J Pediatr Surg. 39(4):522-5, 2004