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Metabolic Bone Disease
Umesh D. Oza, MD; Daniel G. Hampton, MD
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KEY FACTS

  • Terminology

    • Imaging

      TERMINOLOGY

      • Definitions

        • Metabolic bone disease 
          • Broad term for diseases that result in bone strength or mineralization abnormalities
          • Common indication for bone scan is increased alkaline phosphatase and bone pain
          • Overlap of bone scan findings of osteomalacia, renal osteodystrophy, and hyperparathyroidism

      IMAGING

      • General Features

        • Nuclear Medicine Findings

          • Imaging Recommendations

            DIFFERENTIAL DIAGNOSIS

              CLINICAL ISSUES

              • Presentation

                Selected References

                1. Abdelrazek S et al: Bone scan in metabolic bone diseases. Review. Nucl Med Rev Cent East Eur. 15(2):124-31, 2012
                2. Cook GJ et al: Miscellaneous indications in bone scintigraphy: metabolic bone diseases and malignant bone tumors. Semin Nucl Med. 40(1):52-61, 2010
                3. Martin KJ et al: Metabolic bone disease in chronic kidney disease. J Am Soc Nephrol. 18(3):875-85, 2007
                4. Pour MC et al: Diffuse increased uptake on bone scan: super scan. Semin Nucl Med. 34(2):154-6, 2004
                5. Peller PJ et al: Extraosseous Tc-99m MDP uptake: a pathophysiologic approach. Radiographics. 13(4):715-34, 1993
                6. Spitz J et al: Scintimetric evaluation of remodeling after bone fractures in man. J Nucl Med. 34(9):1403-9, 1993
                7. McAfee JG: Radionuclide imaging in metabolic and systemic skeletal diseases. Semin Nucl Med. 17(4):334-49, 1987
                Related Anatomy
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                Related Differential Diagnoses
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                References
                Tables

                Tables

                KEY FACTS

                • Terminology

                  • Imaging

                    TERMINOLOGY

                    • Definitions

                      • Metabolic bone disease 
                        • Broad term for diseases that result in bone strength or mineralization abnormalities
                        • Common indication for bone scan is increased alkaline phosphatase and bone pain
                        • Overlap of bone scan findings of osteomalacia, renal osteodystrophy, and hyperparathyroidism

                    IMAGING

                    • General Features

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            CLINICAL ISSUES

                            • Presentation

                              Selected References

                              1. Abdelrazek S et al: Bone scan in metabolic bone diseases. Review. Nucl Med Rev Cent East Eur. 15(2):124-31, 2012
                              2. Cook GJ et al: Miscellaneous indications in bone scintigraphy: metabolic bone diseases and malignant bone tumors. Semin Nucl Med. 40(1):52-61, 2010
                              3. Martin KJ et al: Metabolic bone disease in chronic kidney disease. J Am Soc Nephrol. 18(3):875-85, 2007
                              4. Pour MC et al: Diffuse increased uptake on bone scan: super scan. Semin Nucl Med. 34(2):154-6, 2004
                              5. Peller PJ et al: Extraosseous Tc-99m MDP uptake: a pathophysiologic approach. Radiographics. 13(4):715-34, 1993
                              6. Spitz J et al: Scintimetric evaluation of remodeling after bone fractures in man. J Nucl Med. 34(9):1403-9, 1993
                              7. McAfee JG: Radionuclide imaging in metabolic and systemic skeletal diseases. Semin Nucl Med. 17(4):334-49, 1987