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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
Carcinosarcoma, carcinoma with sarcomatous metaplasia, sarcomatoid carcinoma
Definitions
Heterogeneous group of neoplasms with both epithelial and mesenchymal differentiation that consists entirely or in part of 3 main categories
Squamous or spindle cell, matrix-producing, and true malignant mesenchymal component (carcinosarcoma)
Rare variant of invasive ductal carcinoma
Despite heterogeneity within tumor, likely monoclonal origin
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Donato H et al: Imaging findings of metaplastic carcinoma of the breast with pathologic correlation. J Belg Soc Radiol. 102(1):46, 2018
Hasdemir OA et al: Clinicopathological features of metaplastic breast carcinoma. Adv Clin Exp Med. 27(4):509-513, 2018
Murphy BL et al: Management of the axilla in metaplastic breast carcinoma. Gland Surg. 7(2):200-206, 2018
Ong CT et al: Metaplastic breast cancer treatment and outcomes in 2500 patients: a retrospective analysis of a national oncology database. Ann Surg Oncol. 25(8):2249-2260, 2018
Yin H et al: Metaplastic squamous cell carcinoma of breast demonstrated on 18F-FDG PET/CT. Clin Nucl Med. 43(5):341-343, 2018
Mituś JW et al: Metaplastic breast cancer with rapidly progressive recurrence in a young woman: case report and review of the literature. Arch Med Sci. 12(6):1384-1388, 2016
Abouharb S et al: Metaplastic breast cancer: clinical overview and molecular aberrations for potential targeted therapy. Curr Oncol Rep. 17(3):431, 2015
McKinnon E et al: Metaplastic carcinoma of the breast. Arch Pathol Lab Med. 139(6):819-22, 2015
Paul Wright G et al: Hormone receptor status does not affect prognosis in metaplastic breast cancer: a population-based analysis with comparison to infiltrating ductal and lobular carcinomas. Ann Surg Oncol. 21(11):3497-503, 2014
Ryckman EM et al: AIRP best cases in radiologic-pathologic correlation: metaplastic squamous cell carcinoma of the breast. Radiographics. 33(7):2019-24, 2013
Choi BB et al: Metaplastic carcinoma of the breast: multimodality imaging and histopathologic assessment. Acta Radiol. 53(1):5-11, 2012
Lee H et al: Metaplastic breast cancer: clinicopathological features and its prognosis. J Clin Pathol. 65(5):441-6, 2012
Rungta S et al: Metaplastic carcinomas of the breast: diagnostic challenges and new translational insights. Arch Pathol Lab Med. 136(8):896-900, 2012
Yoo JL et al: Can MR Imaging contribute in characterizing well-circumscribed breast carcinomas? Radiographics. 30(6):1689-702, 2010
Luini A et al: Metaplastic carcinoma of the breast, an unusual disease with worse prognosis: the experience of the European Institute of Oncology and review of the literature. Breast Cancer Res Treat. 101(3):349-53, 2007
Shin HJ et al: Imaging features of metaplastic carcinoma with chondroid differentiation of the breast. AJR Am J Roentgenol. 188(3):691-6, 2007
Yang WT et al: Imaging differences in metaplastic and invasive ductal carcinomas of the breast. AJR Am J Roentgenol. 189(6):1288-93, 2007
Beatty JD et al: Metaplastic breast cancer: clinical significance. Am J Surg. 191(5):657-64, 2006
Carter MR et al: Spindle cell (sarcomatoid) carcinoma of the breast: a clinicopathologic and immunohistochemical analysis of 29 cases. Am J Surg Pathol. 30(3):300-9, 2006
Dave G et al: Metaplastic carcinoma of the breast: a retrospective review. Int J Radiat Oncol Biol Phys. 64(3):771-5, 2006
Tse GM et al: Metaplastic carcinoma of the breast: a clinicopathological review. J Clin Pathol. 59(10):1079-83, 2006
Tse GM et al: p63 is useful in the diagnosis of mammary metaplastic carcinomas. Pathology. 38(1):16-20, 2006
Gibson GR et al: Metaplastic breast cancer: clinical features and outcomes. Am Surg. 71(9):725-30, 2005
Velasco M et al: MRI of metaplastic carcinoma of the breast. AJR Am J Roentgenol. 184(4):1274-8, 2005
Günhan-Bilgen I et al: Metaplastic carcinoma of the breast: clinical, mammographic, and sonographic findings with histopathologic correlation. AJR Am J Roentgenol. 178(6):1421-5, 2002
Kurian KM et al: Sarcomatoid/metaplastic carcinoma of the breast: a clinicopathological study of 12 cases. Histopathology. 40(1):58-64, 2002
Sneige N et al: Low-grade (fibromatosis-like) spindle cell carcinoma of the breast. Am J Surg Pathol. 25(8):1009-16, 2001
Park JM et al: Metaplastic carcinoma of the breast: mammographic and sonographic findings. J Clin Ultrasound. 28(4):179-86, 2000
Gobbi H et al: Metaplastic breast tumors with a dominant fibromatosis-like phenotype have a high risk of local recurrence. Cancer. 85(10):2170-82, 1999
Rayson D et al: Metaplastic breast cancer: prognosis and response to systemic therapy. Ann Oncol. 10(4):413-9, 1999
Brenner RJ et al: Metaplastic carcinoma of the breast: report of three cases. Cancer. 82(6):1082-7, 1998
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
Carcinosarcoma, carcinoma with sarcomatous metaplasia, sarcomatoid carcinoma
Definitions
Heterogeneous group of neoplasms with both epithelial and mesenchymal differentiation that consists entirely or in part of 3 main categories
Squamous or spindle cell, matrix-producing, and true malignant mesenchymal component (carcinosarcoma)
Rare variant of invasive ductal carcinoma
Despite heterogeneity within tumor, likely monoclonal origin
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Donato H et al: Imaging findings of metaplastic carcinoma of the breast with pathologic correlation. J Belg Soc Radiol. 102(1):46, 2018
Hasdemir OA et al: Clinicopathological features of metaplastic breast carcinoma. Adv Clin Exp Med. 27(4):509-513, 2018
Murphy BL et al: Management of the axilla in metaplastic breast carcinoma. Gland Surg. 7(2):200-206, 2018
Ong CT et al: Metaplastic breast cancer treatment and outcomes in 2500 patients: a retrospective analysis of a national oncology database. Ann Surg Oncol. 25(8):2249-2260, 2018
Yin H et al: Metaplastic squamous cell carcinoma of breast demonstrated on 18F-FDG PET/CT. Clin Nucl Med. 43(5):341-343, 2018
Mituś JW et al: Metaplastic breast cancer with rapidly progressive recurrence in a young woman: case report and review of the literature. Arch Med Sci. 12(6):1384-1388, 2016
Abouharb S et al: Metaplastic breast cancer: clinical overview and molecular aberrations for potential targeted therapy. Curr Oncol Rep. 17(3):431, 2015
McKinnon E et al: Metaplastic carcinoma of the breast. Arch Pathol Lab Med. 139(6):819-22, 2015
Paul Wright G et al: Hormone receptor status does not affect prognosis in metaplastic breast cancer: a population-based analysis with comparison to infiltrating ductal and lobular carcinomas. Ann Surg Oncol. 21(11):3497-503, 2014
Ryckman EM et al: AIRP best cases in radiologic-pathologic correlation: metaplastic squamous cell carcinoma of the breast. Radiographics. 33(7):2019-24, 2013
Choi BB et al: Metaplastic carcinoma of the breast: multimodality imaging and histopathologic assessment. Acta Radiol. 53(1):5-11, 2012
Lee H et al: Metaplastic breast cancer: clinicopathological features and its prognosis. J Clin Pathol. 65(5):441-6, 2012
Rungta S et al: Metaplastic carcinomas of the breast: diagnostic challenges and new translational insights. Arch Pathol Lab Med. 136(8):896-900, 2012
Yoo JL et al: Can MR Imaging contribute in characterizing well-circumscribed breast carcinomas? Radiographics. 30(6):1689-702, 2010
Luini A et al: Metaplastic carcinoma of the breast, an unusual disease with worse prognosis: the experience of the European Institute of Oncology and review of the literature. Breast Cancer Res Treat. 101(3):349-53, 2007
Shin HJ et al: Imaging features of metaplastic carcinoma with chondroid differentiation of the breast. AJR Am J Roentgenol. 188(3):691-6, 2007
Yang WT et al: Imaging differences in metaplastic and invasive ductal carcinomas of the breast. AJR Am J Roentgenol. 189(6):1288-93, 2007
Beatty JD et al: Metaplastic breast cancer: clinical significance. Am J Surg. 191(5):657-64, 2006
Carter MR et al: Spindle cell (sarcomatoid) carcinoma of the breast: a clinicopathologic and immunohistochemical analysis of 29 cases. Am J Surg Pathol. 30(3):300-9, 2006
Dave G et al: Metaplastic carcinoma of the breast: a retrospective review. Int J Radiat Oncol Biol Phys. 64(3):771-5, 2006
Tse GM et al: Metaplastic carcinoma of the breast: a clinicopathological review. J Clin Pathol. 59(10):1079-83, 2006
Tse GM et al: p63 is useful in the diagnosis of mammary metaplastic carcinomas. Pathology. 38(1):16-20, 2006
Gibson GR et al: Metaplastic breast cancer: clinical features and outcomes. Am Surg. 71(9):725-30, 2005
Velasco M et al: MRI of metaplastic carcinoma of the breast. AJR Am J Roentgenol. 184(4):1274-8, 2005
Günhan-Bilgen I et al: Metaplastic carcinoma of the breast: clinical, mammographic, and sonographic findings with histopathologic correlation. AJR Am J Roentgenol. 178(6):1421-5, 2002
Kurian KM et al: Sarcomatoid/metaplastic carcinoma of the breast: a clinicopathological study of 12 cases. Histopathology. 40(1):58-64, 2002
Sneige N et al: Low-grade (fibromatosis-like) spindle cell carcinoma of the breast. Am J Surg Pathol. 25(8):1009-16, 2001
Park JM et al: Metaplastic carcinoma of the breast: mammographic and sonographic findings. J Clin Ultrasound. 28(4):179-86, 2000
Gobbi H et al: Metaplastic breast tumors with a dominant fibromatosis-like phenotype have a high risk of local recurrence. Cancer. 85(10):2170-82, 1999
Rayson D et al: Metaplastic breast cancer: prognosis and response to systemic therapy. Ann Oncol. 10(4):413-9, 1999
Brenner RJ et al: Metaplastic carcinoma of the breast: report of three cases. Cancer. 82(6):1082-7, 1998
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