link
Bookmarks
Metastases of Bone Marrow
Behrang Amini, MD, PhD; B. J. Manaster, MD, PhD, FACR
To access 4,300 diagnoses written by the world's leading experts in radiology.Try it free - 15 days
2
42
24
2

KEY FACTS

  • Terminology

    • Imaging

      • Diagnostic Checklist

        TERMINOLOGY

        • Synonyms

          • Metastatic disease, skeletal deposits, bone metastasis, secondary malignant neoplasm of bone, bone implants
        • Definitions

          • Tumor involving bone, which originated from distant site
          • Oligometastatic disease: intermediate state between localized and disseminated metastatic disease with small number of lesions
          • Oligoprogressive disease: progression of small number of lesions on background of overall stable metastatic disease
          • Small number depends on local preference, clinical trial, proximity of lesions/amenability to local therapy

        IMAGING

        • General Features

          • Radiographic Findings

            • CT Findings

              • MR Findings

                • Imaging Recommendations

                  • Nuclear Medicine Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Zampetti B et al: False positive of 68Ga-DOTATATE PET-CT in a paraganglioma. Endocr Metab Immune Disord Drug Targets. 21(7):1352-5, 2021
                                        2. Guckenberger M et al: Characterisation and classification of oligometastatic disease: a European Society for Radiotherapy and Oncology and European Organisation for Research and Treatment of Cancer consensus recommendation. Lancet Oncol. 21(1):e18-28, 2020
                                        3. Usmani S et al: Spectrum of false positive 18F-sodium fluoride (NaF) bone PET/CT findings in oncology imaging; a narrative pictorial review of cases from a single institution. Hell J Nucl Med. 23(1):67-75, 2020
                                        4. Demirci E et al: Dual false positive of ⁶⁸Ga-DOTA-TATE PET/CT scan in a patient with a history of pancreatic neuroendocrine tumor: a case report. Rev Esp Med Nucl Imagen Mol. 34(2):133-5, 2015
                                        5. Hillner BE et al: 18F-fluoride PET used for treatment monitoring of systemic cancer therapy: results from the National Oncologic PET Registry. J Nucl Med. 56(2):222-8, 2015
                                        6. Laufer I et al: The NOMS framework: approach to the treatment of spinal metastatic tumors. Oncologist. 18(6):744-51, 2013
                                        7. Donovan A et al: Radiological features of superomedial iliac insufficiency fractures: a possible mimicker of metastatic disease. Skeletal Radiol. 38(1):43-9, 2009
                                        8. Kinkel S et al: Compound osteosynthesis for osteolyses and pathological fractures of the proximal femur. Orthopedics. 32(6):403, 2009
                                        9. Hsu WK et al: Characterization of osteolytic, osteoblastic, and mixed lesions in a prostate cancer mouse model using 18F-FDG and 18F-fluoride PET/CT. J Nucl Med. 49(3):414-21, 2008
                                        10. Tateishi U et al: Bone metastases in patients with metastatic breast cancer: morphologic and metabolic monitoring of response to systemic therapy with integrated PET/CT. Radiology. 247(1):189-96, 2008
                                        11. Taira AV et al: Detection of bone metastases: assessment of integrated FDG PET/CT imaging. Radiology. 243(1):204-11, 2007
                                        12. Callstrom MR et al: Painful metastases involving bone: percutaneous image-guided cryoablation--prospective trial interim analysis. Radiology. 241(2):572-80, 2006
                                        13. Choi JA et al: Osseous metastasis from renal cell carcinoma: "flow-void" sign at MR imaging. Radiology. 228(3):629-34, 2003
                                        14. Jung HS et al: Discrimination of metastatic from acute osteoporotic compression spinal fractures with MR imaging. Radiographics. 23(1):179-87, 2003
                                        15. Herneth AM et al: Vertebral metastases: assessment with apparent diffusion coefficient. Radiology. 225(3):889-94, 2002
                                        16. Jambhekar NA et al: Metastases involving bone. In Fletcher CDM et al: World Health Organization Classification of Tumors: Tumours of Soft Tissue and Bone. IARC Press. 334-5, 2002
                                        17. Rompe JD et al: Metastatic instability at the proximal end of the femur. Comparison of endoprosthetic replacement and plate osteosynthesis. Arch Orthop Trauma Surg. 113(5):260-4, 1994
                                        18. Mirels H et al: A proposed scoring system for diagnosing impending pathologic fractures. Clin Orthop Relat Res. 249: 256-64. 1989
                                        19. Edelstyn GA et al: The radiological demonstration of osseous metastases. Experimental observations. Clin Radiol. 18(2):158-62, 1967
                                        Related Anatomy
                                        Loading...
                                        Related Differential Diagnoses
                                        Loading...
                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Diagnostic Checklist

                                              TERMINOLOGY

                                              • Synonyms

                                                • Metastatic disease, skeletal deposits, bone metastasis, secondary malignant neoplasm of bone, bone implants
                                              • Definitions

                                                • Tumor involving bone, which originated from distant site
                                                • Oligometastatic disease: intermediate state between localized and disseminated metastatic disease with small number of lesions
                                                • Oligoprogressive disease: progression of small number of lesions on background of overall stable metastatic disease
                                                • Small number depends on local preference, clinical trial, proximity of lesions/amenability to local therapy

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Imaging Recommendations

                                                        • Nuclear Medicine Findings

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          DIAGNOSTIC CHECKLIST

                                                                          • Consider

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Zampetti B et al: False positive of 68Ga-DOTATATE PET-CT in a paraganglioma. Endocr Metab Immune Disord Drug Targets. 21(7):1352-5, 2021
                                                                              2. Guckenberger M et al: Characterisation and classification of oligometastatic disease: a European Society for Radiotherapy and Oncology and European Organisation for Research and Treatment of Cancer consensus recommendation. Lancet Oncol. 21(1):e18-28, 2020
                                                                              3. Usmani S et al: Spectrum of false positive 18F-sodium fluoride (NaF) bone PET/CT findings in oncology imaging; a narrative pictorial review of cases from a single institution. Hell J Nucl Med. 23(1):67-75, 2020
                                                                              4. Demirci E et al: Dual false positive of ⁶⁸Ga-DOTA-TATE PET/CT scan in a patient with a history of pancreatic neuroendocrine tumor: a case report. Rev Esp Med Nucl Imagen Mol. 34(2):133-5, 2015
                                                                              5. Hillner BE et al: 18F-fluoride PET used for treatment monitoring of systemic cancer therapy: results from the National Oncologic PET Registry. J Nucl Med. 56(2):222-8, 2015
                                                                              6. Laufer I et al: The NOMS framework: approach to the treatment of spinal metastatic tumors. Oncologist. 18(6):744-51, 2013
                                                                              7. Donovan A et al: Radiological features of superomedial iliac insufficiency fractures: a possible mimicker of metastatic disease. Skeletal Radiol. 38(1):43-9, 2009
                                                                              8. Kinkel S et al: Compound osteosynthesis for osteolyses and pathological fractures of the proximal femur. Orthopedics. 32(6):403, 2009
                                                                              9. Hsu WK et al: Characterization of osteolytic, osteoblastic, and mixed lesions in a prostate cancer mouse model using 18F-FDG and 18F-fluoride PET/CT. J Nucl Med. 49(3):414-21, 2008
                                                                              10. Tateishi U et al: Bone metastases in patients with metastatic breast cancer: morphologic and metabolic monitoring of response to systemic therapy with integrated PET/CT. Radiology. 247(1):189-96, 2008
                                                                              11. Taira AV et al: Detection of bone metastases: assessment of integrated FDG PET/CT imaging. Radiology. 243(1):204-11, 2007
                                                                              12. Callstrom MR et al: Painful metastases involving bone: percutaneous image-guided cryoablation--prospective trial interim analysis. Radiology. 241(2):572-80, 2006
                                                                              13. Choi JA et al: Osseous metastasis from renal cell carcinoma: "flow-void" sign at MR imaging. Radiology. 228(3):629-34, 2003
                                                                              14. Jung HS et al: Discrimination of metastatic from acute osteoporotic compression spinal fractures with MR imaging. Radiographics. 23(1):179-87, 2003
                                                                              15. Herneth AM et al: Vertebral metastases: assessment with apparent diffusion coefficient. Radiology. 225(3):889-94, 2002
                                                                              16. Jambhekar NA et al: Metastases involving bone. In Fletcher CDM et al: World Health Organization Classification of Tumors: Tumours of Soft Tissue and Bone. IARC Press. 334-5, 2002
                                                                              17. Rompe JD et al: Metastatic instability at the proximal end of the femur. Comparison of endoprosthetic replacement and plate osteosynthesis. Arch Orthop Trauma Surg. 113(5):260-4, 1994
                                                                              18. Mirels H et al: A proposed scoring system for diagnosing impending pathologic fractures. Clin Orthop Relat Res. 249: 256-64. 1989
                                                                              19. Edelstyn GA et al: The radiological demonstration of osseous metastases. Experimental observations. Clin Radiol. 18(2):158-62, 1967