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Metastatic Intracranial Lymphoma
Karen L. Salzman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Synonyms

              • Secondary CNS lymphoma (SCNSL)
            • Definitions

              • Secondary involvement of CNS in patients with systemic lymphoma

            IMAGING

            • General Features

              • Imaging Recommendations

                • CT Findings

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. Cheah CY et al: Central nervous system prophylaxis in non-Hodgkin lymphoma: who, what, and when? Curr Oncol Rep. 17(6):25, 2015
                                        2. Chen YB et al: Phase 2 trial of high-dose rituximab with high-dose cytarabine mobilization therapy and high-dose thiotepa, busulfan, and cyclophosphamide autologous stem cell transplantation in patients with central nervous system involvement by non-Hodgkin lymphoma. Cancer. 121(2):226-33, 2015
                                        3. Oh DH et al: Treatment of patients with secondary central nervous system lymphoma with high-dose busulfan/thiotepa-based conditioning and autologous stem cell transplant. Leuk Lymphoma. 1-6, 2015
                                        4. Baraniskin A et al: Modern cerebrospinal fluid analyses for the diagnosis of diffuse large B-cell lymphoma of the CNS. CNS Oncol. 3(1):77-85, 2014
                                        5. Ferreri AJ: Risk of CNS dissemination in extranodal lymphomas. Lancet Oncol. 15(4):e159-69, 2014
                                        6. Kickingereder P et al: Evaluation of microvascular permeability with dynamic contrast-enhanced MRI for the differentiation of primary CNS lymphoma and glioblastoma: radiologic-pathologic correlation. AJNR Am J Neuroradiol. 35(8):1503-8, 2014
                                        7. Lee IH et al: Analysis of perfusion weighted image of CNS lymphoma. Eur J Radiol. Epub ahead of print, 2009
                                        8. Doolittle ND et al: Brain parenchyma involvement as isolated central nervous system relapse of systemic non-Hodgkin lymphoma: an International Primary CNS Lymphoma Collaborative Group report. Blood. 111(3):1085-93, 2008
                                        9. van Besien K et al: Secondary lymphomas of the central nervous system: risk, prophylaxis and treatment. Leuk Lymphoma. 49 Suppl 1:52-8, 2008
                                        10. Björkholm M et al: Central nervous system occurrence in elderly patients with aggressive lymphoma and a long-term follow-up. Ann Oncol. 18(6):1085-9, 2007
                                        11. Boehme V et al: Incidence and risk factors of central nervous system recurrence in aggressive lymphoma--a survey of 1693 patients treated in protocols of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). Ann Oncol. 18(1):149-57, 2007
                                        12. Gleissner B et al: Treatment of CNS dissemination in systemic lymphoma. J Neurooncol. 84(1):107-17, 2007
                                        13. Louis DN et al: WHO classification of tumours of the central nervous system: Malignant lymphomas. Lyon: IARC Press. 188-92, 2007
                                        14. Grupka NL et al: Secondary central nervous system involvement by follicular lymphoma: case report and review of the literature. Surg Neurol. 65(6):590-4, 2006
                                        15. Jahnke K et al: Retrospective study of prognostic factors in non-Hodgkin lymphoma secondarily involving the central nervous system. Ann Hematol. 85(1):45-50, 2006
                                        16. Marinković M et al: Extranodal marginal zone B-cell lymphoma most probably of MALT type appearing in CNS as parasagittal extracerebral tumor. J Neurosurg Sci. 50(1):9-12, 2006
                                        17. Mazhar D et al: Non-Hodgkin's lymphoma and the CNS: prophylaxis and therapy in immunocompetent and HIV-positive individuals. Expert Rev Anticancer Ther. 6(3):335-41, 2006
                                        18. Tomita N et al: Secondary central nervous system lymphoma. Int J Hematol. 84(2):128-35, 2006
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Synonyms

                                                    • Secondary CNS lymphoma (SCNSL)
                                                  • Definitions

                                                    • Secondary involvement of CNS in patients with systemic lymphoma

                                                  IMAGING

                                                  • General Features

                                                    • Imaging Recommendations

                                                      • CT Findings

                                                        • MR Findings

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Staging, Grading, & Classification

                                                                • Gross Pathologic & Surgical Features

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. Cheah CY et al: Central nervous system prophylaxis in non-Hodgkin lymphoma: who, what, and when? Curr Oncol Rep. 17(6):25, 2015
                                                                              2. Chen YB et al: Phase 2 trial of high-dose rituximab with high-dose cytarabine mobilization therapy and high-dose thiotepa, busulfan, and cyclophosphamide autologous stem cell transplantation in patients with central nervous system involvement by non-Hodgkin lymphoma. Cancer. 121(2):226-33, 2015
                                                                              3. Oh DH et al: Treatment of patients with secondary central nervous system lymphoma with high-dose busulfan/thiotepa-based conditioning and autologous stem cell transplant. Leuk Lymphoma. 1-6, 2015
                                                                              4. Baraniskin A et al: Modern cerebrospinal fluid analyses for the diagnosis of diffuse large B-cell lymphoma of the CNS. CNS Oncol. 3(1):77-85, 2014
                                                                              5. Ferreri AJ: Risk of CNS dissemination in extranodal lymphomas. Lancet Oncol. 15(4):e159-69, 2014
                                                                              6. Kickingereder P et al: Evaluation of microvascular permeability with dynamic contrast-enhanced MRI for the differentiation of primary CNS lymphoma and glioblastoma: radiologic-pathologic correlation. AJNR Am J Neuroradiol. 35(8):1503-8, 2014
                                                                              7. Lee IH et al: Analysis of perfusion weighted image of CNS lymphoma. Eur J Radiol. Epub ahead of print, 2009
                                                                              8. Doolittle ND et al: Brain parenchyma involvement as isolated central nervous system relapse of systemic non-Hodgkin lymphoma: an International Primary CNS Lymphoma Collaborative Group report. Blood. 111(3):1085-93, 2008
                                                                              9. van Besien K et al: Secondary lymphomas of the central nervous system: risk, prophylaxis and treatment. Leuk Lymphoma. 49 Suppl 1:52-8, 2008
                                                                              10. Björkholm M et al: Central nervous system occurrence in elderly patients with aggressive lymphoma and a long-term follow-up. Ann Oncol. 18(6):1085-9, 2007
                                                                              11. Boehme V et al: Incidence and risk factors of central nervous system recurrence in aggressive lymphoma--a survey of 1693 patients treated in protocols of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). Ann Oncol. 18(1):149-57, 2007
                                                                              12. Gleissner B et al: Treatment of CNS dissemination in systemic lymphoma. J Neurooncol. 84(1):107-17, 2007
                                                                              13. Louis DN et al: WHO classification of tumours of the central nervous system: Malignant lymphomas. Lyon: IARC Press. 188-92, 2007
                                                                              14. Grupka NL et al: Secondary central nervous system involvement by follicular lymphoma: case report and review of the literature. Surg Neurol. 65(6):590-4, 2006
                                                                              15. Jahnke K et al: Retrospective study of prognostic factors in non-Hodgkin lymphoma secondarily involving the central nervous system. Ann Hematol. 85(1):45-50, 2006
                                                                              16. Marinković M et al: Extranodal marginal zone B-cell lymphoma most probably of MALT type appearing in CNS as parasagittal extracerebral tumor. J Neurosurg Sci. 50(1):9-12, 2006
                                                                              17. Mazhar D et al: Non-Hodgkin's lymphoma and the CNS: prophylaxis and therapy in immunocompetent and HIV-positive individuals. Expert Rev Anticancer Ther. 6(3):335-41, 2006
                                                                              18. Tomita N et al: Secondary central nervous system lymphoma. Int J Hematol. 84(2):128-35, 2006