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Metastatic Neuroblastoma
Kevin R. Moore, MD; Anne G. Osborn, MD, FACR; Chang Yueh Ho, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Neuroblastoma (NB), neuroblastic tumors (NBT)
              • Definitions

                • Malignant tumor of sympathetic nervous system arising from embryonal neural crest cell derivatives

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                Selected References

                                                1. Hill-Kayser CE et al: Outcomes after proton therapy for treatment of pediatric high-risk neuroblastoma. Int J Radiat Oncol Biol Phys. 104(2):401-8, 2019
                                                2. Li C et al: Prognostic value of metabolic indices and bone marrow uptake pattern on preoperative 18F-FDG PET/CT in pediatric patients with neuroblastoma. Eur J Nucl Med Mol Imaging. 45(2):306-15, 2018
                                                3. Tomolonis JA et al: Neuroblastoma pathogenesis: deregulation of embryonic neural crest development. Cell Tissue Res. 372(2):245-62, 2018
                                                4. Ahmed AA et al: Neuroblastoma in children: update on clinicopathologic and genetic prognostic factors. Pediatr Hematol Oncol. 34(3):165-85, 2017
                                                5. Di Cataldo A et al: Metastatic neuroblastoma in infants: are survival rates excellent only within the stringent framework of clinical trials? Clin Transl Oncol. 19(1):76-83, 2017
                                                6. DuBois SG et al: MIBG avidity correlates with clinical features, tumor biology, and outcomes in neuroblastoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 64(11), 2017
                                                7. Newman EA et al: Recent biologic and genetic advances in neuroblastoma: implications for diagnostic, risk stratification, and treatment strategies. Semin Pediatr Surg. 25(5):257-64, 2016
                                                8. Latimer E et al: Ultrastructural features of neuroblastic tumours in relation to morphological, and molecular findings; a retrospective review study. BMC Clin Pathol. 14(1):13, 2014
                                                9. Nabavizadeh SA et al: CT and MRI of pediatric skull lesions with fluid-fluid levels. AJNR Am J Neuroradiol. 35(3):604-8, 2014
                                                10. Nabavizadeh SA et al: Imaging findings of patients with metastatic neuroblastoma to the brain. Acad Radiol. 21(3):329-37, 2014
                                                11. Wiens AL et al: The pathological spectrum of solid CNS metastases in the pediatric population. J Neurosurg Pediatr. 14(2):129-35, 2014
                                                12. Khandeparkar SG et al: Primary congenital sacrococcygeal neuroblastoma: a case report with immunohistochemical study and review of literature. J Pediatr Neurosci. 8(3):239-42, 2013
                                                13. Liu B et al: Comparison of [123I]MIBG and [131I]MIBG for imaging of neuroblastoma and other neural crest tumors. Q J Nucl Med Mol Imaging. 57(1):21-8, 2013
                                                14. Mueller WP et al: Nuclear medicine and multimodality imaging of pediatric neuroblastoma. Pediatr Radiol. 43(4):418-27, 2013
                                                15. Piccardo A et al: PET/CT imaging in neuroblastoma. Q J Nucl Med Mol Imaging. 57(1):29-39, 2013
                                                16. D'Ambrosio N et al: Imaging of metastatic CNS neuroblastoma. AJR Am J Roentgenol. 194(5):1223-9, 2010
                                                17. Heck JE et al: The epidemiology of neuroblastoma: a review. Paediatr Perinat Epidemiol. 23(2):125-43, 2009
                                                18. Rothenberg AB et al: The association between neuroblastoma and opsoclonus-myoclonus syndrome: a historical review. Pediatr Radiol. 39(7):723-6, 2009
                                                19. Chung EM et al: From the Archives of the AFIP. Pediatric orbit tumors and tumorlike lesions: osseous lesions of the orbit. Radiographics. 28(4):1193-214, 2008
                                                20. Scanga DR et al: Value of FDG PET imaging in the management of patients with thyroid, neuroendocrine, and neural crest tumors. Clin Nucl Med. 29(2):86-90, 2004
                                                21. Jaing TH et al: Brain metastases in children with neuroblastoma--a single-institution experience. Med Pediatr Oncol. 41(6):570-1, 2003
                                                22. Pfluger T et al: Integrated imaging using MRI and 123I metaiodobenzylguanidine scintigraphy to improve sensitivity and specificity in the diagnosis of pediatric neuroblastoma. AJR Am J Roentgenol. 181(4):1115-24, 2003
                                                23. Lonergan GJ et al: Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. 22(4):911-34, 2002
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Pathology

                                                        • Clinical Issues

                                                          • Diagnostic Checklist

                                                            TERMINOLOGY

                                                            • Abbreviations

                                                              • Neuroblastoma (NB), neuroblastic tumors (NBT)
                                                            • Definitions

                                                              • Malignant tumor of sympathetic nervous system arising from embryonal neural crest cell derivatives

                                                            IMAGING

                                                            • General Features

                                                              • Radiographic Findings

                                                                • CT Findings

                                                                  • MR Findings

                                                                    • Nuclear Medicine Findings

                                                                      • Imaging Recommendations

                                                                        DIFFERENTIAL DIAGNOSIS

                                                                          PATHOLOGY

                                                                          • General Features

                                                                            • Staging, Grading, & Classification

                                                                              • Gross Pathologic & Surgical Features

                                                                                • Microscopic Features

                                                                                  CLINICAL ISSUES

                                                                                  • Presentation

                                                                                    • Demographics

                                                                                      • Natural History & Prognosis

                                                                                        • Treatment

                                                                                          DIAGNOSTIC CHECKLIST

                                                                                          • Consider

                                                                                            • Image Interpretation Pearls

                                                                                              Selected References

                                                                                              1. Hill-Kayser CE et al: Outcomes after proton therapy for treatment of pediatric high-risk neuroblastoma. Int J Radiat Oncol Biol Phys. 104(2):401-8, 2019
                                                                                              2. Li C et al: Prognostic value of metabolic indices and bone marrow uptake pattern on preoperative 18F-FDG PET/CT in pediatric patients with neuroblastoma. Eur J Nucl Med Mol Imaging. 45(2):306-15, 2018
                                                                                              3. Tomolonis JA et al: Neuroblastoma pathogenesis: deregulation of embryonic neural crest development. Cell Tissue Res. 372(2):245-62, 2018
                                                                                              4. Ahmed AA et al: Neuroblastoma in children: update on clinicopathologic and genetic prognostic factors. Pediatr Hematol Oncol. 34(3):165-85, 2017
                                                                                              5. Di Cataldo A et al: Metastatic neuroblastoma in infants: are survival rates excellent only within the stringent framework of clinical trials? Clin Transl Oncol. 19(1):76-83, 2017
                                                                                              6. DuBois SG et al: MIBG avidity correlates with clinical features, tumor biology, and outcomes in neuroblastoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 64(11), 2017
                                                                                              7. Newman EA et al: Recent biologic and genetic advances in neuroblastoma: implications for diagnostic, risk stratification, and treatment strategies. Semin Pediatr Surg. 25(5):257-64, 2016
                                                                                              8. Latimer E et al: Ultrastructural features of neuroblastic tumours in relation to morphological, and molecular findings; a retrospective review study. BMC Clin Pathol. 14(1):13, 2014
                                                                                              9. Nabavizadeh SA et al: CT and MRI of pediatric skull lesions with fluid-fluid levels. AJNR Am J Neuroradiol. 35(3):604-8, 2014
                                                                                              10. Nabavizadeh SA et al: Imaging findings of patients with metastatic neuroblastoma to the brain. Acad Radiol. 21(3):329-37, 2014
                                                                                              11. Wiens AL et al: The pathological spectrum of solid CNS metastases in the pediatric population. J Neurosurg Pediatr. 14(2):129-35, 2014
                                                                                              12. Khandeparkar SG et al: Primary congenital sacrococcygeal neuroblastoma: a case report with immunohistochemical study and review of literature. J Pediatr Neurosci. 8(3):239-42, 2013
                                                                                              13. Liu B et al: Comparison of [123I]MIBG and [131I]MIBG for imaging of neuroblastoma and other neural crest tumors. Q J Nucl Med Mol Imaging. 57(1):21-8, 2013
                                                                                              14. Mueller WP et al: Nuclear medicine and multimodality imaging of pediatric neuroblastoma. Pediatr Radiol. 43(4):418-27, 2013
                                                                                              15. Piccardo A et al: PET/CT imaging in neuroblastoma. Q J Nucl Med Mol Imaging. 57(1):29-39, 2013
                                                                                              16. D'Ambrosio N et al: Imaging of metastatic CNS neuroblastoma. AJR Am J Roentgenol. 194(5):1223-9, 2010
                                                                                              17. Heck JE et al: The epidemiology of neuroblastoma: a review. Paediatr Perinat Epidemiol. 23(2):125-43, 2009
                                                                                              18. Rothenberg AB et al: The association between neuroblastoma and opsoclonus-myoclonus syndrome: a historical review. Pediatr Radiol. 39(7):723-6, 2009
                                                                                              19. Chung EM et al: From the Archives of the AFIP. Pediatric orbit tumors and tumorlike lesions: osseous lesions of the orbit. Radiographics. 28(4):1193-214, 2008
                                                                                              20. Scanga DR et al: Value of FDG PET imaging in the management of patients with thyroid, neuroendocrine, and neural crest tumors. Clin Nucl Med. 29(2):86-90, 2004
                                                                                              21. Jaing TH et al: Brain metastases in children with neuroblastoma--a single-institution experience. Med Pediatr Oncol. 41(6):570-1, 2003
                                                                                              22. Pfluger T et al: Integrated imaging using MRI and 123I metaiodobenzylguanidine scintigraphy to improve sensitivity and specificity in the diagnosis of pediatric neuroblastoma. AJR Am J Roentgenol. 181(4):1115-24, 2003
                                                                                              23. Lonergan GJ et al: Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. 22(4):911-34, 2002