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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Neuroblastoma (NB), neuroblastic tumors (NBT)
Definitions
- Malignant tumor of sympathetic nervous system arising from embryonal neural crest cell derivatives
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Hill-Kayser CE et al: Outcomes after proton therapy for treatment of pediatric high-risk neuroblastoma. Int J Radiat Oncol Biol Phys. 104(2):401-8, 2019
- Li C et al: Prognostic value of metabolic indices and bone marrow uptake pattern on preoperative 18F-FDG PET/CT in pediatric patients with neuroblastoma. Eur J Nucl Med Mol Imaging. 45(2):306-15, 2018
- Tomolonis JA et al: Neuroblastoma pathogenesis: deregulation of embryonic neural crest development. Cell Tissue Res. 372(2):245-62, 2018
- Ahmed AA et al: Neuroblastoma in children: update on clinicopathologic and genetic prognostic factors. Pediatr Hematol Oncol. 34(3):165-85, 2017
- Di Cataldo A et al: Metastatic neuroblastoma in infants: are survival rates excellent only within the stringent framework of clinical trials? Clin Transl Oncol. 19(1):76-83, 2017
- DuBois SG et al: MIBG avidity correlates with clinical features, tumor biology, and outcomes in neuroblastoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 64(11), 2017
- Newman EA et al: Recent biologic and genetic advances in neuroblastoma: implications for diagnostic, risk stratification, and treatment strategies. Semin Pediatr Surg. 25(5):257-64, 2016
- Latimer E et al: Ultrastructural features of neuroblastic tumours in relation to morphological, and molecular findings; a retrospective review study. BMC Clin Pathol. 14(1):13, 2014
- Nabavizadeh SA et al: CT and MRI of pediatric skull lesions with fluid-fluid levels. AJNR Am J Neuroradiol. 35(3):604-8, 2014
- Nabavizadeh SA et al: Imaging findings of patients with metastatic neuroblastoma to the brain. Acad Radiol. 21(3):329-37, 2014
- Wiens AL et al: The pathological spectrum of solid CNS metastases in the pediatric population. J Neurosurg Pediatr. 14(2):129-35, 2014
- Khandeparkar SG et al: Primary congenital sacrococcygeal neuroblastoma: a case report with immunohistochemical study and review of literature. J Pediatr Neurosci. 8(3):239-42, 2013
- Liu B et al: Comparison of [123I]MIBG and [131I]MIBG for imaging of neuroblastoma and other neural crest tumors. Q J Nucl Med Mol Imaging. 57(1):21-8, 2013
- Mueller WP et al: Nuclear medicine and multimodality imaging of pediatric neuroblastoma. Pediatr Radiol. 43(4):418-27, 2013
- Piccardo A et al: PET/CT imaging in neuroblastoma. Q J Nucl Med Mol Imaging. 57(1):29-39, 2013
- D'Ambrosio N et al: Imaging of metastatic CNS neuroblastoma. AJR Am J Roentgenol. 194(5):1223-9, 2010
- Heck JE et al: The epidemiology of neuroblastoma: a review. Paediatr Perinat Epidemiol. 23(2):125-43, 2009
- Rothenberg AB et al: The association between neuroblastoma and opsoclonus-myoclonus syndrome: a historical review. Pediatr Radiol. 39(7):723-6, 2009
- Chung EM et al: From the Archives of the AFIP. Pediatric orbit tumors and tumorlike lesions: osseous lesions of the orbit. Radiographics. 28(4):1193-214, 2008
- Scanga DR et al: Value of FDG PET imaging in the management of patients with thyroid, neuroendocrine, and neural crest tumors. Clin Nucl Med. 29(2):86-90, 2004
- Jaing TH et al: Brain metastases in children with neuroblastoma--a single-institution experience. Med Pediatr Oncol. 41(6):570-1, 2003
- Pfluger T et al: Integrated imaging using MRI and 123I metaiodobenzylguanidine scintigraphy to improve sensitivity and specificity in the diagnosis of pediatric neuroblastoma. AJR Am J Roentgenol. 181(4):1115-24, 2003
- Lonergan GJ et al: Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. 22(4):911-34, 2002
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Neuroblastoma (NB), neuroblastic tumors (NBT)
Definitions
- Malignant tumor of sympathetic nervous system arising from embryonal neural crest cell derivatives
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Hill-Kayser CE et al: Outcomes after proton therapy for treatment of pediatric high-risk neuroblastoma. Int J Radiat Oncol Biol Phys. 104(2):401-8, 2019
- Li C et al: Prognostic value of metabolic indices and bone marrow uptake pattern on preoperative 18F-FDG PET/CT in pediatric patients with neuroblastoma. Eur J Nucl Med Mol Imaging. 45(2):306-15, 2018
- Tomolonis JA et al: Neuroblastoma pathogenesis: deregulation of embryonic neural crest development. Cell Tissue Res. 372(2):245-62, 2018
- Ahmed AA et al: Neuroblastoma in children: update on clinicopathologic and genetic prognostic factors. Pediatr Hematol Oncol. 34(3):165-85, 2017
- Di Cataldo A et al: Metastatic neuroblastoma in infants: are survival rates excellent only within the stringent framework of clinical trials? Clin Transl Oncol. 19(1):76-83, 2017
- DuBois SG et al: MIBG avidity correlates with clinical features, tumor biology, and outcomes in neuroblastoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 64(11), 2017
- Newman EA et al: Recent biologic and genetic advances in neuroblastoma: implications for diagnostic, risk stratification, and treatment strategies. Semin Pediatr Surg. 25(5):257-64, 2016
- Latimer E et al: Ultrastructural features of neuroblastic tumours in relation to morphological, and molecular findings; a retrospective review study. BMC Clin Pathol. 14(1):13, 2014
- Nabavizadeh SA et al: CT and MRI of pediatric skull lesions with fluid-fluid levels. AJNR Am J Neuroradiol. 35(3):604-8, 2014
- Nabavizadeh SA et al: Imaging findings of patients with metastatic neuroblastoma to the brain. Acad Radiol. 21(3):329-37, 2014
- Wiens AL et al: The pathological spectrum of solid CNS metastases in the pediatric population. J Neurosurg Pediatr. 14(2):129-35, 2014
- Khandeparkar SG et al: Primary congenital sacrococcygeal neuroblastoma: a case report with immunohistochemical study and review of literature. J Pediatr Neurosci. 8(3):239-42, 2013
- Liu B et al: Comparison of [123I]MIBG and [131I]MIBG for imaging of neuroblastoma and other neural crest tumors. Q J Nucl Med Mol Imaging. 57(1):21-8, 2013
- Mueller WP et al: Nuclear medicine and multimodality imaging of pediatric neuroblastoma. Pediatr Radiol. 43(4):418-27, 2013
- Piccardo A et al: PET/CT imaging in neuroblastoma. Q J Nucl Med Mol Imaging. 57(1):29-39, 2013
- D'Ambrosio N et al: Imaging of metastatic CNS neuroblastoma. AJR Am J Roentgenol. 194(5):1223-9, 2010
- Heck JE et al: The epidemiology of neuroblastoma: a review. Paediatr Perinat Epidemiol. 23(2):125-43, 2009
- Rothenberg AB et al: The association between neuroblastoma and opsoclonus-myoclonus syndrome: a historical review. Pediatr Radiol. 39(7):723-6, 2009
- Chung EM et al: From the Archives of the AFIP. Pediatric orbit tumors and tumorlike lesions: osseous lesions of the orbit. Radiographics. 28(4):1193-214, 2008
- Scanga DR et al: Value of FDG PET imaging in the management of patients with thyroid, neuroendocrine, and neural crest tumors. Clin Nucl Med. 29(2):86-90, 2004
- Jaing TH et al: Brain metastases in children with neuroblastoma--a single-institution experience. Med Pediatr Oncol. 41(6):570-1, 2003
- Pfluger T et al: Integrated imaging using MRI and 123I metaiodobenzylguanidine scintigraphy to improve sensitivity and specificity in the diagnosis of pediatric neuroblastoma. AJR Am J Roentgenol. 181(4):1115-24, 2003
- Lonergan GJ et al: Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. 22(4):911-34, 2002
