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Metastatic Pulmonary Calcification
Tomás Franquet, MD, PhD; Jud W. Gurney, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Metastatic pulmonary calcification (MPC)
              • Synonyms

                • Pulmonary calcinosis
              • Definitions

                • Pulmonary calcification
                  • Dystrophic calcification
                    • Calcium deposition in injured pulmonary parenchyma
                    • Absence of ↑ serum calcium levels
                  • Metastatic calcification
                    • Calcium deposition in normal pulmonary parenchyma
                    • Abnormal calcium metabolism
                    • Predisposing factors: Chronic renal failure, hypercalcemia, and increased tissue alkalinity
                • Calciphylaxis
                  • Small vessel calcification leading to end-organ ischemia
                  • May result in rapidly fatal noncardiac edema

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • Nuclear Medicine Findings

                      • MR Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Arrestier R et al: Successful treatment of lung calciphylaxis with sodium thiosulfate in a patient with sickle cell disease: a case report. Medicine (Baltimore). 95(6):e2768, 2016
                                            2. Belém LC et al: Metastatic pulmonary calcification: state-of-the-art review focused on imaging findings. Respir Med. 108(5):668-76, 2014
                                            3. Yasuo M et al: Progressive pulmonary calcification after successful renal transplantation. Intern Med. 47(3):161-4, 2008
                                            4. Li YJ et al: Fulminant pulmonary calciphylaxis and metastatic calcification causing acute respiratory failure in a uremic patient. Am J Kidney Dis. 47(4):e47-53, 2006
                                            5. Chung MJ et al: Metabolic lung disease: imaging and histopathologic findings. Eur J Radiol. 54(2):233-45, 2005
                                            6. Hartman TE et al: Metastatic pulmonary calcification in patients with hypercalcemia: findings on chest radiographs and CT scans. AJR Am J Roentgenol. 162(4):799-802, 1994
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Metastatic pulmonary calcification (MPC)
                                                        • Synonyms

                                                          • Pulmonary calcinosis
                                                        • Definitions

                                                          • Pulmonary calcification
                                                            • Dystrophic calcification
                                                              • Calcium deposition in injured pulmonary parenchyma
                                                              • Absence of ↑ serum calcium levels
                                                            • Metastatic calcification
                                                              • Calcium deposition in normal pulmonary parenchyma
                                                              • Abnormal calcium metabolism
                                                              • Predisposing factors: Chronic renal failure, hypercalcemia, and increased tissue alkalinity
                                                          • Calciphylaxis
                                                            • Small vessel calcification leading to end-organ ischemia
                                                            • May result in rapidly fatal noncardiac edema

                                                        IMAGING

                                                        • General Features

                                                          • Radiographic Findings

                                                            • CT Findings

                                                              • Nuclear Medicine Findings

                                                                • MR Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Arrestier R et al: Successful treatment of lung calciphylaxis with sodium thiosulfate in a patient with sickle cell disease: a case report. Medicine (Baltimore). 95(6):e2768, 2016
                                                                                      2. Belém LC et al: Metastatic pulmonary calcification: state-of-the-art review focused on imaging findings. Respir Med. 108(5):668-76, 2014
                                                                                      3. Yasuo M et al: Progressive pulmonary calcification after successful renal transplantation. Intern Med. 47(3):161-4, 2008
                                                                                      4. Li YJ et al: Fulminant pulmonary calciphylaxis and metastatic calcification causing acute respiratory failure in a uremic patient. Am J Kidney Dis. 47(4):e47-53, 2006
                                                                                      5. Chung MJ et al: Metabolic lung disease: imaging and histopathologic findings. Eur J Radiol. 54(2):233-45, 2005
                                                                                      6. Hartman TE et al: Metastatic pulmonary calcification in patients with hypercalcemia: findings on chest radiographs and CT scans. AJR Am J Roentgenol. 162(4):799-802, 1994