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Brain
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Pathology-Based Diagnoses
Acquired Toxic/Metabolic/Degenerative Disorders
Toxic, Metabolic, Nutritional, Systemic Diseases With CNS Manifestations
Methanol Poisoning
Methanol Poisoning
Miral D. Jhaveri, MD, MBA
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Methanol (MtOH)

            • Definitions

              • MtOH toxicity/poisoning/encephalopathy
              • Acute toxic effects of MtOH on CNS

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          CLINICAL ISSUES

                          • Presentation

                            • Natural History & Prognosis

                              • Treatment

                                Selected References

                                1. de Oliveira AM et al: Imaging patterns of toxic and metabolic brain disorders. Radiographics. 39(6):1672-95, 2019
                                2. Mana J et al: Methanol poisoning as an acute toxicological basal ganglia lesion model: evidence from brain volumetry and cognition. Alcohol Clin Exp Res. 43(7):1486-97, 2019
                                3. Quinn MP et al: Putaminal diffusion restriction in a case of methanol toxicity with clinical recovery. Can J Neurol Sci. 1-2, 2019
                                4. Holt NR et al: Severe methanol poisoning with neurological sequelae: implications for diagnosis and management. Intern Med J. 48(3):335-9, 2018
                                5. Anderson D et al: Teaching NeuroImages: brain imaging findings in acute methanol toxicity. Neurology. 89(22):e264, 2017
                                6. Paliwal VK et al: Haemorrhagic putaminal necrosis, optic atrophy and coma: a triad suggestive of methanol poisoning. Anaesth Intensive Care. 44(5):636-7, 2016
                                7. Vaneckova M et al: Imaging findings after methanol intoxication (cohort of 46 patients). Neuro Endocrinol Lett. 36(8):737-44, 2015
                                8. Grasso D et al: Lentiform fork sign: a magnetic resonance finding in a case of acute metabolic acidosis. Neuroradiol J. 27(3):288-92, 2014
                                9. Rietjens SJ et al: Ethylene glycol or methanol intoxication: which antidote should be used, fomepizole or ethanol? Neth J Med. 72(2):73-9, 2014
                                10. Jain N et al: Methanol poisoning: characteristic MRI findings. Ann Saudi Med. 33(1):68-9, 2013
                                11. Thirunavukkarasu S et al: Acute bilateral putaminal haemorrhagic necrosis in methanol poisoning. BMJ Case Rep. 2013, 2013
                                12. Azeemuddin M et al: MRI findings in methanol intoxication: a report of three cases. J Pak Med Assoc. 62(10):1099-101, 2012
                                13. Taheri MS et al: The value of brain CT findings in acute methanol toxicity. Eur J Radiol. 73(2):211-4, 2010
                                14. Ahsan H et al: Diffusion weighted image (DWI) findings in methanol intoxication. J Pak Med Assoc. 59(5):321-3, 2009
                                15. Brent J: Fomepizole for ethylene glycol and methanol poisoning. N Engl J Med. 360(21):2216-23, 2009
                                16. Bronstein AC et al: 2007 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 25th Annual Report. Clin Toxicol (Phila). 46(10):927-1057, 2008
                                17. Keleş GT et al: Methanol poisoning with necrosis corpus callosum. Clin Toxicol (Phila). 45(3):307-8, 2007
                                18. Server A et al: Conventional and diffusion-weighted MRI in the evaluation of methanol poisoning. Acta Radiol. 44(6):691-5, 2003
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Pathology

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Methanol (MtOH)

                                          • Definitions

                                            • MtOH toxicity/poisoning/encephalopathy
                                            • Acute toxic effects of MtOH on CNS

                                          IMAGING

                                          • General Features

                                            • CT Findings

                                              • MR Findings

                                                • Imaging Recommendations

                                                  DIFFERENTIAL DIAGNOSIS

                                                    PATHOLOGY

                                                    • General Features

                                                      • Gross Pathologic & Surgical Features

                                                        CLINICAL ISSUES

                                                        • Presentation

                                                          • Natural History & Prognosis

                                                            • Treatment

                                                              Selected References

                                                              1. de Oliveira AM et al: Imaging patterns of toxic and metabolic brain disorders. Radiographics. 39(6):1672-95, 2019
                                                              2. Mana J et al: Methanol poisoning as an acute toxicological basal ganglia lesion model: evidence from brain volumetry and cognition. Alcohol Clin Exp Res. 43(7):1486-97, 2019
                                                              3. Quinn MP et al: Putaminal diffusion restriction in a case of methanol toxicity with clinical recovery. Can J Neurol Sci. 1-2, 2019
                                                              4. Holt NR et al: Severe methanol poisoning with neurological sequelae: implications for diagnosis and management. Intern Med J. 48(3):335-9, 2018
                                                              5. Anderson D et al: Teaching NeuroImages: brain imaging findings in acute methanol toxicity. Neurology. 89(22):e264, 2017
                                                              6. Paliwal VK et al: Haemorrhagic putaminal necrosis, optic atrophy and coma: a triad suggestive of methanol poisoning. Anaesth Intensive Care. 44(5):636-7, 2016
                                                              7. Vaneckova M et al: Imaging findings after methanol intoxication (cohort of 46 patients). Neuro Endocrinol Lett. 36(8):737-44, 2015
                                                              8. Grasso D et al: Lentiform fork sign: a magnetic resonance finding in a case of acute metabolic acidosis. Neuroradiol J. 27(3):288-92, 2014
                                                              9. Rietjens SJ et al: Ethylene glycol or methanol intoxication: which antidote should be used, fomepizole or ethanol? Neth J Med. 72(2):73-9, 2014
                                                              10. Jain N et al: Methanol poisoning: characteristic MRI findings. Ann Saudi Med. 33(1):68-9, 2013
                                                              11. Thirunavukkarasu S et al: Acute bilateral putaminal haemorrhagic necrosis in methanol poisoning. BMJ Case Rep. 2013, 2013
                                                              12. Azeemuddin M et al: MRI findings in methanol intoxication: a report of three cases. J Pak Med Assoc. 62(10):1099-101, 2012
                                                              13. Taheri MS et al: The value of brain CT findings in acute methanol toxicity. Eur J Radiol. 73(2):211-4, 2010
                                                              14. Ahsan H et al: Diffusion weighted image (DWI) findings in methanol intoxication. J Pak Med Assoc. 59(5):321-3, 2009
                                                              15. Brent J: Fomepizole for ethylene glycol and methanol poisoning. N Engl J Med. 360(21):2216-23, 2009
                                                              16. Bronstein AC et al: 2007 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 25th Annual Report. Clin Toxicol (Phila). 46(10):927-1057, 2008
                                                              17. Keleş GT et al: Methanol poisoning with necrosis corpus callosum. Clin Toxicol (Phila). 45(3):307-8, 2007
                                                              18. Server A et al: Conventional and diffusion-weighted MRI in the evaluation of methanol poisoning. Acta Radiol. 44(6):691-5, 2003