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Metronidazole Toxicity
Miral D. Jhaveri, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Metronidazole (MTZ)-induced encephalopathy (MIE)
              • Definitions

                • Acute encephalopathy caused by antibiotic drug metronidazole

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Singh R et al: Sequential MR imaging (with diffusion-weighted imaging) changes in metronidazole-induced encephalopathy. Indian J Radiol Imaging. 27(2):129-32, 2017
                                      2. Agarwal A et al: Metronidazole-induced cerebellar toxicity. Neurol Int. 8(1):6365, 2016
                                      3. Roy U et al: Clinical and neuroradiological spectrum of Metronidazole induced encephalopathy: our experience and the review of literature. J Clin Diagn Res. 10(6):OE01-9, 2016
                                      4. Bonda C et al: Metronidazole CNS toxicity. Acta Neurol Belg. 115(4):709-10, 2015
                                      5. Zuccoli G et al: Metronidazole-induced and Wernicke encephalopathy: two different entities sharing the same metabolic pathway? AJNR Am J Neuroradiol. 29(9):E84; author reply E85, 2008
                                      6. Kim E et al: MR imaging of metronidazole-induced encephalopathy: lesion distribution and diffusion-weighted imaging findings. AJNR Am J Neuroradiol. 28(9):1652-8, 2007
                                      7. Heaney CJ et al: MR imaging and diffusion-weighted imaging changes in metronidazole (Flagyl)-induced cerebellar toxicity. AJNR Am J Neuroradiol. 24(8):1615-7, 2003
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Metronidazole (MTZ)-induced encephalopathy (MIE)
                                                  • Definitions

                                                    • Acute encephalopathy caused by antibiotic drug metronidazole

                                                  IMAGING

                                                  • General Features

                                                    • CT Findings

                                                      • MR Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      DIAGNOSTIC CHECKLIST

                                                                      • Consider

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Singh R et al: Sequential MR imaging (with diffusion-weighted imaging) changes in metronidazole-induced encephalopathy. Indian J Radiol Imaging. 27(2):129-32, 2017
                                                                          2. Agarwal A et al: Metronidazole-induced cerebellar toxicity. Neurol Int. 8(1):6365, 2016
                                                                          3. Roy U et al: Clinical and neuroradiological spectrum of Metronidazole induced encephalopathy: our experience and the review of literature. J Clin Diagn Res. 10(6):OE01-9, 2016
                                                                          4. Bonda C et al: Metronidazole CNS toxicity. Acta Neurol Belg. 115(4):709-10, 2015
                                                                          5. Zuccoli G et al: Metronidazole-induced and Wernicke encephalopathy: two different entities sharing the same metabolic pathway? AJNR Am J Neuroradiol. 29(9):E84; author reply E85, 2008
                                                                          6. Kim E et al: MR imaging of metronidazole-induced encephalopathy: lesion distribution and diffusion-weighted imaging findings. AJNR Am J Neuroradiol. 28(9):1652-8, 2007
                                                                          7. Heaney CJ et al: MR imaging and diffusion-weighted imaging changes in metronidazole (Flagyl)-induced cerebellar toxicity. AJNR Am J Neuroradiol. 24(8):1615-7, 2003