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Microlobulated Margins
Wendie A. Berg, MD, PhD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Diagnostic Checklist

            TERMINOLOGY

            • Definitions

              • Short-cycle undulations of mass margins
              • Subtype of margins considered "not circumscribed"
              • Not to be confused with shape descriptors
                • 2-3 gentle lobulations = oval shape
                • ≥ 4 gentle lobulations = irregular shape

            IMAGING

            • General Features

              • Mammographic Findings

                • Ultrasonographic Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Microscopic Features

                            DIAGNOSTIC CHECKLIST

                            • Consider

                              Selected References

                              1. Sohn YM et al: Breast lesions diagnosed by ultrasound-guided core needle biopsy: Can shearwave elastography predict histologic upgrade after surgery or vaccuum assisted excision? Clin Imaging. 49:150-155, 2018
                              2. Wang D et al: Clinicopathological and ultrasonic features of triple-negative breast cancers: A comparison with hormone receptor-positive/human epidermal growth factor receptor-2-negative breast cancers. Ultrasound Med Biol. 44(5):1124-1132, 2018
                              3. Wen X et al: Correlations between ultrasonographic findings of invasive lobular carcinoma of the breast and intrinsic subtypes. Ultraschall Med. ePub, 2018
                              4. Au FW et al: Histological grade and immunohistochemical biomarkers of breast cancer: Correlation to ultrasound features. J Ultrasound Med. 36(9):1883-1894, 2017
                              5. Bitencourt AGV et al: Breast metastases from extramammary malignancies: multimodality imaging aspects. Br J Radiol. 90(1077):20170197, 2017
                              6. Ferré R et al: Sonographic appearance of lesions diagnosed as lobular neoplasia at sonographically guided biopsies. AJR Am J Roentgenol. 208(3):669-675, 2017
                              7. Zeng Z et al: Mammography and ultrasound effective features in differentiating basal-like and normal-like subtypes of triple negative breast cancer. Oncotarget. 8(45):79670-79679, 2017
                              8. Duman L et al: Differentiation between phyllodes tumors and fibroadenomas based on mammographic sonographic and MRI features. Breast Care (Basel). 11(2):123-7, 2016
                              9. Elverici E et al: Nonpalpable BI-RADS 4 breast lesions: sonographic findings and pathology correlation. Diagn Interv Radiol. 21(3):189-94, 2015
                              10. Çelebi F et al: The role of ultrasonographic findings to predict molecular subtype, histologic grade, and hormone receptor status of breast cancer. Diagn Interv Radiol. 21(6):448-53, 2015
                              11. Mesurolle B et al: Atypical ductal hyperplasia diagnosed at sonographically guided core needle biopsy: frequency, final surgical outcome, and factors associated with underestimation. AJR Am J Roentgenol. 202(6):1389-94, 2014
                              12. Mendelson EB et al: Breast Imaging Reporting and Data System, BI-RADS: Ultrasound. 2nd ed. Reston: American College of Radiology, 2013
                              13. Sickles EA et al: Breast Imaging Reporting and Data System, BI-RADS: Mammography. 5th ed. Reston: American College of Radiology, 2013
                              14. Blaichman J et al: Sonographic appearance of invasive ductal carcinoma of the breast according to histologic grade. AJR Am J Roentgenol. 199(3):W402-8, 2012
                              15. Hong AS et al: BI-RADS for sonography: positive and negative predictive values of sonographic features. AJR Am J Roentgenol. 184(4):1260-5, 2005
                              16. D'Orsi CJ et al: Breast Imaging Reporting and Data System, BI-RADS: Mammography. 4th ed. Reston: American College of Radiology, 2003
                              17. Liberman L et al: The breast imaging reporting and data system: positive predictive value of mammographic features and final assessment categories. AJR Am J Roentgenol. 171(1):35-40, 1998
                              Related Anatomy
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                              Related Differential Diagnoses
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                              References
                              Tables

                              Tables

                              KEY FACTS

                              • Terminology

                                • Imaging

                                  • Top Differential Diagnoses

                                    • Pathology

                                      • Diagnostic Checklist

                                        TERMINOLOGY

                                        • Definitions

                                          • Short-cycle undulations of mass margins
                                          • Subtype of margins considered "not circumscribed"
                                          • Not to be confused with shape descriptors
                                            • 2-3 gentle lobulations = oval shape
                                            • ≥ 4 gentle lobulations = irregular shape

                                        IMAGING

                                        • General Features

                                          • Mammographic Findings

                                            • Ultrasonographic Findings

                                              • MR Findings

                                                • Imaging Recommendations

                                                  DIFFERENTIAL DIAGNOSIS

                                                    PATHOLOGY

                                                    • General Features

                                                      • Microscopic Features

                                                        DIAGNOSTIC CHECKLIST

                                                        • Consider

                                                          Selected References

                                                          1. Sohn YM et al: Breast lesions diagnosed by ultrasound-guided core needle biopsy: Can shearwave elastography predict histologic upgrade after surgery or vaccuum assisted excision? Clin Imaging. 49:150-155, 2018
                                                          2. Wang D et al: Clinicopathological and ultrasonic features of triple-negative breast cancers: A comparison with hormone receptor-positive/human epidermal growth factor receptor-2-negative breast cancers. Ultrasound Med Biol. 44(5):1124-1132, 2018
                                                          3. Wen X et al: Correlations between ultrasonographic findings of invasive lobular carcinoma of the breast and intrinsic subtypes. Ultraschall Med. ePub, 2018
                                                          4. Au FW et al: Histological grade and immunohistochemical biomarkers of breast cancer: Correlation to ultrasound features. J Ultrasound Med. 36(9):1883-1894, 2017
                                                          5. Bitencourt AGV et al: Breast metastases from extramammary malignancies: multimodality imaging aspects. Br J Radiol. 90(1077):20170197, 2017
                                                          6. Ferré R et al: Sonographic appearance of lesions diagnosed as lobular neoplasia at sonographically guided biopsies. AJR Am J Roentgenol. 208(3):669-675, 2017
                                                          7. Zeng Z et al: Mammography and ultrasound effective features in differentiating basal-like and normal-like subtypes of triple negative breast cancer. Oncotarget. 8(45):79670-79679, 2017
                                                          8. Duman L et al: Differentiation between phyllodes tumors and fibroadenomas based on mammographic sonographic and MRI features. Breast Care (Basel). 11(2):123-7, 2016
                                                          9. Elverici E et al: Nonpalpable BI-RADS 4 breast lesions: sonographic findings and pathology correlation. Diagn Interv Radiol. 21(3):189-94, 2015
                                                          10. Çelebi F et al: The role of ultrasonographic findings to predict molecular subtype, histologic grade, and hormone receptor status of breast cancer. Diagn Interv Radiol. 21(6):448-53, 2015
                                                          11. Mesurolle B et al: Atypical ductal hyperplasia diagnosed at sonographically guided core needle biopsy: frequency, final surgical outcome, and factors associated with underestimation. AJR Am J Roentgenol. 202(6):1389-94, 2014
                                                          12. Mendelson EB et al: Breast Imaging Reporting and Data System, BI-RADS: Ultrasound. 2nd ed. Reston: American College of Radiology, 2013
                                                          13. Sickles EA et al: Breast Imaging Reporting and Data System, BI-RADS: Mammography. 5th ed. Reston: American College of Radiology, 2013
                                                          14. Blaichman J et al: Sonographic appearance of invasive ductal carcinoma of the breast according to histologic grade. AJR Am J Roentgenol. 199(3):W402-8, 2012
                                                          15. Hong AS et al: BI-RADS for sonography: positive and negative predictive values of sonographic features. AJR Am J Roentgenol. 184(4):1260-5, 2005
                                                          16. D'Orsi CJ et al: Breast Imaging Reporting and Data System, BI-RADS: Mammography. 4th ed. Reston: American College of Radiology, 2003
                                                          17. Liberman L et al: The breast imaging reporting and data system: positive predictive value of mammographic features and final assessment categories. AJR Am J Roentgenol. 171(1):35-40, 1998