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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Abbreviations
- Middle ear adenoma (MEA)
Synonyms
- Adenomatous tumor of middle ear (ME)
- ME carcinoid, neuroendocrine adenoma, adenomatoid tumor
- Numerous acronyms: Mixed epithelial and neuroendocrine tumor (MENET), neuroendocrine adenoma of ME (NAME), ME adenoma with neuroendocrine differentiation (MEA-ND), ME adenomatous tumors (MEAT)
Definitions
- Very rare, benign tumor arising from mucosal cells of ME having variable mixed epithelial and neuroendocrine differentiation
- Not choristoma or ceruminoma
- Salivary choristoma = normal salivary tissue in abnormal location, not adenoma
- Ceruminoma = benign glandular tumor (adenoma) arising from ceruminous glands
- Not choristoma or ceruminoma
- Indolent tumor of glandular origin
- Very rare, benign tumor arising from mucosal cells of ME having variable mixed epithelial and neuroendocrine differentiation
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
- Asa SL et al: Middle ear "adenoma": a neuroendocrine tumor with predominant L cell differentiation. Endocr Pathol. ePub, 2021
- van der Lans RJL et al: Neuroendocrine neoplasms of the middle ear: unpredictable tumor behavior and tendency for recurrence. Head Neck. 43(6):1848-53, 2021
- Zwierz A et al: Preoperative diagnosis and treatment of middle ear adenoma: a case report and literature review. Ear Nose Throat J. 100(3_suppl):360S-3S, 2021
- Bruschini L et al: Middle ear neuroendocrine adenoma: a case report and literature review. Case Rep Otolaryngol. 2020:8863188, 2020
- Fedorová K et al: Middle ear adenoma imitating late postoperative complication. Ear Nose Throat J. 145561320935846, 2020
- Shishido T et al: Middle ear adenoma with facial palsy: a case report and a review of the literature: middle ear adenoma with facial palsy. Auris Nasus Larynx. ePub, 2020
- Yadav SK et al: Middle ear adenoma with neuroendocrine differentiation: report of a rare case. Indian J Cancer. 57(1):98-101, 2020
- Sterrer E et al: Middle ear adenoma with neuroendocrine differentiation: a pediatric case report. Wien Klin Wochenschr. 129(5-6):208-11, 2017
- Wang L et al: Middle ear adenoma with uncommon presentation and literature review. BMJ Case Rep. 2017
- Hu H et al: Neuroendocrine adenoma of middle ear with new bone formation and review of literature. Am J Otolaryngol. 37(2):108-11, 2016
- Agaimy A et al: 'Neuroendocrine' middle ear adenomas: consistent expression of the transcription factor ISL1 further supports their neuroendocrine derivation. Histopathology. 66(2):182-91, 2015
- Pelosi S et al: Adenomatous tumors of the middle ear. Otolaryngol Clin North Am. 48(2):305-15, 2015
- Baku M et al: A rare case of middle ear adenoma. Nagoya J Med Sci. 76(3-4):355-60, 2014
- Isenring D et al: Middle ear adenoma: case report and discussion. Case Rep Otolaryngol. 2014:342125, 2014
- Xu B et al: Neuroendocrine neoplasms of the head and neck: some suggestions for the new WHO classification of head and neck tumors. Head Neck Pathol. 8(1):24-32, 2014
- Duderstadt M et al: Adenomatous tumors of the middle ear and temporal bone: clinical, morphological and tumor biological characteristics of challenging neoplastic lesions. Eur Arch Otorhinolaryngol. 269(3):823-31, 2012
- Giuseppe M et al: Adenoma of the ceruminous gland (ceruminoma). Otol Neurotol. 32(2):e14-5, 2011
- Tomazic PV et al: Neuroendocrine adenoma of the middle ear (NAME) mimicking as chronic otitis media with an episode of facial nerve palsy. B-ENT. 7(2):121-5, 2011
- Bierry G et al: Middle ear adenomatous tumor: a not so rare glomus tympanicum-mimicking lesion. J Neuroradiol. 37(2):116-21, 2010
- Dogru S et al: Middle ear adenoma with neuroendocrine differentiation (MEA-ND) in the pediatric population. Int J Pediatr Otorhinolaryngol. 73(6):895-8, 2009
- Mori E et al: Middle ear adenoma diagnosed by recurrent facial paralysis. Auris Nasus Larynx. 36(1):75-8, 2009
- Zan E et al: Middle ear adenoma: a challenging diagnosis. AJNR Am J Neuroradiol. 30(8):1602-3, 2009
- Sahan M et al: Carcinoid tumor of the middle ear: report of a case. Am J Otolaryngol. 29(5):352-6, 2008
- Berns S et al: Middle ear adenoma. Arch Pathol Lab Med. 130(7):1067-9, 2006
- Thompson LD et al: Ceruminous adenomas: a clinicopathologic study of 41 cases with a review of the literature. Am J Surg Pathol. 28(3):308-18, 2004
- Devaney KO et al: Epithelial tumors of the middle ear--are middle ear carcinoids really distinct from middle ear adenomas? Acta Otolaryngol. 123(6):678-82, 2003
- Torske KR et al: Adenoma versus carcinoid tumor of the middle ear: a study of 48 cases and review of the literature. Mod Pathol. 15(5):543-55, 2002
- Jones SE et al: Adenoma in the middle ear: a report of two cases. J Laryngol Otol. 115(3):216-9, 2001
- Ketabchi S et al: Middle ear adenoma is an amphicrine tumor: why call it adenoma? Ultrastruct Pathol. 25(1):73-8, 2001
- Maintz D et al: MRI and CT of adenomatous tumours of the middle ear. Neuroradiology. 43(1):58-61, 2001
- Gunduz M et al: Middle ear adenoma with neuroendocrine differentiation. Auris Nasus Larynx. 27(1):73-6, 2000
- Smith MM et al: Choristomas of the seventh and eighth cranial nerves. AJNR Am J Neuroradiol. 18(2):327-9, 1997
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Abbreviations
- Middle ear adenoma (MEA)
Synonyms
- Adenomatous tumor of middle ear (ME)
- ME carcinoid, neuroendocrine adenoma, adenomatoid tumor
- Numerous acronyms: Mixed epithelial and neuroendocrine tumor (MENET), neuroendocrine adenoma of ME (NAME), ME adenoma with neuroendocrine differentiation (MEA-ND), ME adenomatous tumors (MEAT)
Definitions
- Very rare, benign tumor arising from mucosal cells of ME having variable mixed epithelial and neuroendocrine differentiation
- Not choristoma or ceruminoma
- Salivary choristoma = normal salivary tissue in abnormal location, not adenoma
- Ceruminoma = benign glandular tumor (adenoma) arising from ceruminous glands
- Not choristoma or ceruminoma
- Indolent tumor of glandular origin
- Very rare, benign tumor arising from mucosal cells of ME having variable mixed epithelial and neuroendocrine differentiation
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
- Asa SL et al: Middle ear "adenoma": a neuroendocrine tumor with predominant L cell differentiation. Endocr Pathol. ePub, 2021
- van der Lans RJL et al: Neuroendocrine neoplasms of the middle ear: unpredictable tumor behavior and tendency for recurrence. Head Neck. 43(6):1848-53, 2021
- Zwierz A et al: Preoperative diagnosis and treatment of middle ear adenoma: a case report and literature review. Ear Nose Throat J. 100(3_suppl):360S-3S, 2021
- Bruschini L et al: Middle ear neuroendocrine adenoma: a case report and literature review. Case Rep Otolaryngol. 2020:8863188, 2020
- Fedorová K et al: Middle ear adenoma imitating late postoperative complication. Ear Nose Throat J. 145561320935846, 2020
- Shishido T et al: Middle ear adenoma with facial palsy: a case report and a review of the literature: middle ear adenoma with facial palsy. Auris Nasus Larynx. ePub, 2020
- Yadav SK et al: Middle ear adenoma with neuroendocrine differentiation: report of a rare case. Indian J Cancer. 57(1):98-101, 2020
- Sterrer E et al: Middle ear adenoma with neuroendocrine differentiation: a pediatric case report. Wien Klin Wochenschr. 129(5-6):208-11, 2017
- Wang L et al: Middle ear adenoma with uncommon presentation and literature review. BMJ Case Rep. 2017
- Hu H et al: Neuroendocrine adenoma of middle ear with new bone formation and review of literature. Am J Otolaryngol. 37(2):108-11, 2016
- Agaimy A et al: 'Neuroendocrine' middle ear adenomas: consistent expression of the transcription factor ISL1 further supports their neuroendocrine derivation. Histopathology. 66(2):182-91, 2015
- Pelosi S et al: Adenomatous tumors of the middle ear. Otolaryngol Clin North Am. 48(2):305-15, 2015
- Baku M et al: A rare case of middle ear adenoma. Nagoya J Med Sci. 76(3-4):355-60, 2014
- Isenring D et al: Middle ear adenoma: case report and discussion. Case Rep Otolaryngol. 2014:342125, 2014
- Xu B et al: Neuroendocrine neoplasms of the head and neck: some suggestions for the new WHO classification of head and neck tumors. Head Neck Pathol. 8(1):24-32, 2014
- Duderstadt M et al: Adenomatous tumors of the middle ear and temporal bone: clinical, morphological and tumor biological characteristics of challenging neoplastic lesions. Eur Arch Otorhinolaryngol. 269(3):823-31, 2012
- Giuseppe M et al: Adenoma of the ceruminous gland (ceruminoma). Otol Neurotol. 32(2):e14-5, 2011
- Tomazic PV et al: Neuroendocrine adenoma of the middle ear (NAME) mimicking as chronic otitis media with an episode of facial nerve palsy. B-ENT. 7(2):121-5, 2011
- Bierry G et al: Middle ear adenomatous tumor: a not so rare glomus tympanicum-mimicking lesion. J Neuroradiol. 37(2):116-21, 2010
- Dogru S et al: Middle ear adenoma with neuroendocrine differentiation (MEA-ND) in the pediatric population. Int J Pediatr Otorhinolaryngol. 73(6):895-8, 2009
- Mori E et al: Middle ear adenoma diagnosed by recurrent facial paralysis. Auris Nasus Larynx. 36(1):75-8, 2009
- Zan E et al: Middle ear adenoma: a challenging diagnosis. AJNR Am J Neuroradiol. 30(8):1602-3, 2009
- Sahan M et al: Carcinoid tumor of the middle ear: report of a case. Am J Otolaryngol. 29(5):352-6, 2008
- Berns S et al: Middle ear adenoma. Arch Pathol Lab Med. 130(7):1067-9, 2006
- Thompson LD et al: Ceruminous adenomas: a clinicopathologic study of 41 cases with a review of the literature. Am J Surg Pathol. 28(3):308-18, 2004
- Devaney KO et al: Epithelial tumors of the middle ear--are middle ear carcinoids really distinct from middle ear adenomas? Acta Otolaryngol. 123(6):678-82, 2003
- Torske KR et al: Adenoma versus carcinoid tumor of the middle ear: a study of 48 cases and review of the literature. Mod Pathol. 15(5):543-55, 2002
- Jones SE et al: Adenoma in the middle ear: a report of two cases. J Laryngol Otol. 115(3):216-9, 2001
- Ketabchi S et al: Middle ear adenoma is an amphicrine tumor: why call it adenoma? Ultrastruct Pathol. 25(1):73-8, 2001
- Maintz D et al: MRI and CT of adenomatous tumours of the middle ear. Neuroradiology. 43(1):58-61, 2001
- Gunduz M et al: Middle ear adenoma with neuroendocrine differentiation. Auris Nasus Larynx. 27(1):73-6, 2000
- Smith MM et al: Choristomas of the seventh and eighth cranial nerves. AJNR Am J Neuroradiol. 18(2):327-9, 1997
