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Minor Salivary Gland Malignancy of Pharyngeal Mucosal Space
Patricia A. Hudgins, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Minor salivary gland malignancy (MSGM) of pharyngeal mucosal space (PMS)
            • Definitions

              • Rare, aggressive tumors arising from MSG in PMS
              • Most common pathology: Adenoid cystic carcinoma (ACCa) > mucoepidermoid carcinoma (MECa) > adenocarcinoma (ADCa)
              • Malignancy developing in pleomorphic adenoma: Carcinoma ex pleomorphic adenoma

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            • Reporting Tips

                                              Selected References

                                              1. Chan RC et al: Head and neck mucoepidermoid carcinoma: a curious association with second primary malignancy. Otolaryngol Head Neck Surg. 151(5):797-801, 2014
                                              2. Kato H et al: CT and MR imaging findings of palatal tumors. Eur J Radiol. 83(3):e137-46, 2014
                                              3. Namboodiripad PC: A review: Immunological markers for malignant salivary gland tumors. J Oral Biol Craniofac Res. 4(2):127-34, 2014
                                              4. Nobis CP et al: Head and neck salivary gland carcinomas--elective neck dissection, yes or no? J Oral Maxillofac Surg. 72(1):205-10, 2014
                                              5. Villanueva NL et al: Transoral robotic surgery for the management of oropharyngeal minor salivary gland tumors. Head Neck. 36(1):28-33, 2014
                                              6. Sharma P et al: Utility of (18)F-FDG PET-CT in staging and restaging of patients with malignant salivary gland tumours: a single-institutional experience. Nucl Med Commun. 34(3):211-9, 2013
                                              7. Singh Nanda KD et al: Fine-needle aspiration cytology: a reliable tool in the diagnosis of salivary gland lesions. J Oral Pathol Med. 41(1):106-12, 2012
                                              8. Cianchetti M et al: Radiation therapy for minor salivary gland carcinoma. Laryngoscope. 119(7):1334-8, 2009
                                              9. Ide F et al: Mucinous adenocarcinoma of minor salivary glands: a high-grade malignancy prone to lymph node metastasis. Virchows Arch. 454(1):55-60, 2009
                                              10. Loh KS et al: Prognostic factors in malignancy of the minor salivary glands. Head Neck. 31(1):58-63, 2009
                                              11. Luo SD et al: Estrogen receptor overexpression in malignant minor salivary gland tumors of the sinonasal tract. Otolaryngol Head Neck Surg. 141(1):108-13, 2009
                                              12. Mücke T et al: Advanced malignant minor salivary glands tumors of the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 108(1):81-9, 2009
                                              13. Nakamori K et al: Carcinoma ex pleomorphic adenoma of the buccal region is composed of salivary duct carcinoma and squamous cell carcinoma components. Int J Oral Maxillofac Surg. 38(10):1116-8, 2009
                                              14. Copelli C et al: Malignant tumors of intraoral minor salivary glands. Oral Oncol. 44(7):658-63, 2008
                                              15. Netto Jde N et al: Fine-needle aspiration biopsy as an auxiliary diagnostic tool on intraoral minor salivary gland adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 106(2):242-5, 2008
                                              16. Teppo H et al: Epithelial-myoepithelial carcinoma in minor salivary gland of the hard palate. J Craniofac Surg. 19(6):1689-91, 2008
                                              17. Yang S et al: Clear cell carcinoma, not otherwise specified, of salivary glands: a clinicopathologic study of 4 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 106(5):712-20, 2008
                                              18. Pires FR et al: Intra-oral minor salivary gland tumors: a clinicopathological study of 546 cases. Oral Oncol. 43(5):463-70, 2007
                                              19. Uzochukwu NO et al: Clear cell carcinoma of the base of the tongue: MR imaging findings. AJNR Am J Neuroradiol. 28(1):127-8, 2007
                                              20. Carrasco Ortiz D et al: Adenoid cystic carcinoma of the dorsum of the tongue: presentation of a case. Med Oral Patol Oral Cir Bucal. 11(5):E417-20, 2006
                                              21. Triantafillidou K et al: Mucoepidermoid carcinoma of minor salivary glands: a clinical study of 16 cases and review of the literature. Oral Dis. 12(4):364-70, 2006
                                              22. Strick MJ et al: Malignant tumours of the minor salivary glands--a 20 year review. Br J Plast Surg. 57(7):624-31, 2004
                                              23. Sigal R et al: Adenoid cystic carcinoma of the head and neck: evaluation with MR imaging and clinical-pathologic correlation in 27 patients. Radiology. 184(1):95-101, 1992
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Minor salivary gland malignancy (MSGM) of pharyngeal mucosal space (PMS)
                                                        • Definitions

                                                          • Rare, aggressive tumors arising from MSG in PMS
                                                          • Most common pathology: Adenoid cystic carcinoma (ACCa) > mucoepidermoid carcinoma (MECa) > adenocarcinoma (ADCa)
                                                          • Malignancy developing in pleomorphic adenoma: Carcinoma ex pleomorphic adenoma

                                                        IMAGING

                                                        • General Features

                                                          • CT Findings

                                                            • MR Findings

                                                              • Nuclear Medicine Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Staging, Grading, & Classification

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Consider

                                                                                      • Image Interpretation Pearls

                                                                                        • Reporting Tips

                                                                                          Selected References

                                                                                          1. Chan RC et al: Head and neck mucoepidermoid carcinoma: a curious association with second primary malignancy. Otolaryngol Head Neck Surg. 151(5):797-801, 2014
                                                                                          2. Kato H et al: CT and MR imaging findings of palatal tumors. Eur J Radiol. 83(3):e137-46, 2014
                                                                                          3. Namboodiripad PC: A review: Immunological markers for malignant salivary gland tumors. J Oral Biol Craniofac Res. 4(2):127-34, 2014
                                                                                          4. Nobis CP et al: Head and neck salivary gland carcinomas--elective neck dissection, yes or no? J Oral Maxillofac Surg. 72(1):205-10, 2014
                                                                                          5. Villanueva NL et al: Transoral robotic surgery for the management of oropharyngeal minor salivary gland tumors. Head Neck. 36(1):28-33, 2014
                                                                                          6. Sharma P et al: Utility of (18)F-FDG PET-CT in staging and restaging of patients with malignant salivary gland tumours: a single-institutional experience. Nucl Med Commun. 34(3):211-9, 2013
                                                                                          7. Singh Nanda KD et al: Fine-needle aspiration cytology: a reliable tool in the diagnosis of salivary gland lesions. J Oral Pathol Med. 41(1):106-12, 2012
                                                                                          8. Cianchetti M et al: Radiation therapy for minor salivary gland carcinoma. Laryngoscope. 119(7):1334-8, 2009
                                                                                          9. Ide F et al: Mucinous adenocarcinoma of minor salivary glands: a high-grade malignancy prone to lymph node metastasis. Virchows Arch. 454(1):55-60, 2009
                                                                                          10. Loh KS et al: Prognostic factors in malignancy of the minor salivary glands. Head Neck. 31(1):58-63, 2009
                                                                                          11. Luo SD et al: Estrogen receptor overexpression in malignant minor salivary gland tumors of the sinonasal tract. Otolaryngol Head Neck Surg. 141(1):108-13, 2009
                                                                                          12. Mücke T et al: Advanced malignant minor salivary glands tumors of the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 108(1):81-9, 2009
                                                                                          13. Nakamori K et al: Carcinoma ex pleomorphic adenoma of the buccal region is composed of salivary duct carcinoma and squamous cell carcinoma components. Int J Oral Maxillofac Surg. 38(10):1116-8, 2009
                                                                                          14. Copelli C et al: Malignant tumors of intraoral minor salivary glands. Oral Oncol. 44(7):658-63, 2008
                                                                                          15. Netto Jde N et al: Fine-needle aspiration biopsy as an auxiliary diagnostic tool on intraoral minor salivary gland adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 106(2):242-5, 2008
                                                                                          16. Teppo H et al: Epithelial-myoepithelial carcinoma in minor salivary gland of the hard palate. J Craniofac Surg. 19(6):1689-91, 2008
                                                                                          17. Yang S et al: Clear cell carcinoma, not otherwise specified, of salivary glands: a clinicopathologic study of 4 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 106(5):712-20, 2008
                                                                                          18. Pires FR et al: Intra-oral minor salivary gland tumors: a clinicopathological study of 546 cases. Oral Oncol. 43(5):463-70, 2007
                                                                                          19. Uzochukwu NO et al: Clear cell carcinoma of the base of the tongue: MR imaging findings. AJNR Am J Neuroradiol. 28(1):127-8, 2007
                                                                                          20. Carrasco Ortiz D et al: Adenoid cystic carcinoma of the dorsum of the tongue: presentation of a case. Med Oral Patol Oral Cir Bucal. 11(5):E417-20, 2006
                                                                                          21. Triantafillidou K et al: Mucoepidermoid carcinoma of minor salivary glands: a clinical study of 16 cases and review of the literature. Oral Dis. 12(4):364-70, 2006
                                                                                          22. Strick MJ et al: Malignant tumours of the minor salivary glands--a 20 year review. Br J Plast Surg. 57(7):624-31, 2004
                                                                                          23. Sigal R et al: Adenoid cystic carcinoma of the head and neck: evaluation with MR imaging and clinical-pathologic correlation in 27 patients. Radiology. 184(1):95-101, 1992