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Miscellaneous Malignant Mesenchymal Tumors
Anne G. Osborn, MD, FACR; Gregory L. Katzman, MD, MBA
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Malignant mesenchymal tumors (MMT)
              • Synonyms

                • Malignant nonmeningothelial tumors
              • Definitions

                • Nonmenigotheliomatous malignant mesenchymal neoplasms
                  • Histologically correspond to extracranial tumors of soft tissue or bone
                  • Most are sarcomas
                    • Angiosarcoma (ANGIO), chondrosarcoma (CHON), fibrosarcoma (FIBRO)
                    • Osteosarcoma (OSTEO), rhabdomyosarcoma (RHAB)
                    • Meningeal sarcoma (MENSARC), Ewing sarcoma (EWING), etc.

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Angiographic Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Koyama M et al: Radiation-induced osteosarcoma might mimic metastatic bone lesions: a case with bone scan and FDG PET/CT imaging. Clin Nucl Med. 40(5):427-9, 2015
                                              2. Müller U et al: Is there a role for conventional MRI and MR diffusion-weighted imaging for distinction of skull base chordoma and chondrosarcoma? Acta Radiol. ePub, 2015
                                              3. Hadley C et al: Osteosarcoma of the cranial vault and skull base in pediatric patients. J Neurosurg Pediatr. 13(4):380-7, 2014
                                              4. Jing Z et al: The imaging features of meningeal Ewing sarcoma/peripheral primitive neuroectodermal tumours (pPNETs). Br J Radiol. 87(1041):20130631, 2014
                                              5. Krishnamani K et al: Primary Ewing's sarcoma of the cranium: case series and review of literature. J Cancer Res Ther. 10(2):377-80, 2014
                                              6. Dagcinar A et al: Primary meningeal osteosarcoma of the brain during childhood. Case report. J Neurosurg Pediatr. 1(4):325-9, 2008
                                              7. Guilcher GM et al: Successful treatment of a child with a primary intracranial rhabdomyosarcoma with chemotherapy and radiation therapy. J Neurooncol. 86(1):79-82, 2008
                                              8. Misra V et al: Cytodiagnosis of extraosseous mesenchymal chondrosarcoma of meninges: a case report. Acta Cytol. 52(3):366-8, 2008
                                              9. Bricha M et al: [Primary Ewing sarcoma of the skull vault.] J Radiol. 88(12):1899-901, 2007
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Malignant mesenchymal tumors (MMT)
                                                          • Synonyms

                                                            • Malignant nonmeningothelial tumors
                                                          • Definitions

                                                            • Nonmenigotheliomatous malignant mesenchymal neoplasms
                                                              • Histologically correspond to extracranial tumors of soft tissue or bone
                                                              • Most are sarcomas
                                                                • Angiosarcoma (ANGIO), chondrosarcoma (CHON), fibrosarcoma (FIBRO)
                                                                • Osteosarcoma (OSTEO), rhabdomyosarcoma (RHAB)
                                                                • Meningeal sarcoma (MENSARC), Ewing sarcoma (EWING), etc.

                                                          IMAGING

                                                          • General Features

                                                            • Radiographic Findings

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Angiographic Findings

                                                                    • Imaging Recommendations

                                                                      DIFFERENTIAL DIAGNOSIS

                                                                        PATHOLOGY

                                                                        • General Features

                                                                          • Staging, Grading, & Classification

                                                                            • Gross Pathologic & Surgical Features

                                                                              • Microscopic Features

                                                                                CLINICAL ISSUES

                                                                                • Presentation

                                                                                  • Demographics

                                                                                    • Natural History & Prognosis

                                                                                      • Treatment

                                                                                        DIAGNOSTIC CHECKLIST

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Koyama M et al: Radiation-induced osteosarcoma might mimic metastatic bone lesions: a case with bone scan and FDG PET/CT imaging. Clin Nucl Med. 40(5):427-9, 2015
                                                                                          2. Müller U et al: Is there a role for conventional MRI and MR diffusion-weighted imaging for distinction of skull base chordoma and chondrosarcoma? Acta Radiol. ePub, 2015
                                                                                          3. Hadley C et al: Osteosarcoma of the cranial vault and skull base in pediatric patients. J Neurosurg Pediatr. 13(4):380-7, 2014
                                                                                          4. Jing Z et al: The imaging features of meningeal Ewing sarcoma/peripheral primitive neuroectodermal tumours (pPNETs). Br J Radiol. 87(1041):20130631, 2014
                                                                                          5. Krishnamani K et al: Primary Ewing's sarcoma of the cranium: case series and review of literature. J Cancer Res Ther. 10(2):377-80, 2014
                                                                                          6. Dagcinar A et al: Primary meningeal osteosarcoma of the brain during childhood. Case report. J Neurosurg Pediatr. 1(4):325-9, 2008
                                                                                          7. Guilcher GM et al: Successful treatment of a child with a primary intracranial rhabdomyosarcoma with chemotherapy and radiation therapy. J Neurooncol. 86(1):79-82, 2008
                                                                                          8. Misra V et al: Cytodiagnosis of extraosseous mesenchymal chondrosarcoma of meninges: a case report. Acta Cytol. 52(3):366-8, 2008
                                                                                          9. Bricha M et al: [Primary Ewing sarcoma of the skull vault.] J Radiol. 88(12):1899-901, 2007