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Mixed Congenital Lesions
David Larson, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Diagnostic Checklist

          TERMINOLOGY

          • Synonyms

            • Hybrid lesions
          • Definitions

            • Congenital lung lesion with elements of multiple entities
              • Most common is the "hybrid lesion" of congenital pulmonary airway malformation (CPAM) and pulmonary sequestration
              • Bronchial atresia may also be associated with CPAM &/or sequestration

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • Staging, Grading, & Classification

                        • Gross Pathologic & Surgical Features

                          CLINICAL ISSUES

                          • Presentation

                            • Natural History & Prognosis

                              • Treatment

                                DIAGNOSTIC CHECKLIST

                                • Consider

                                  Selected References

                                  1. Kao SW et al: AIRP best cases in radiologic-pathologic correlation: type 2 congenital cystic adenomatoid malformation (type 2 congenital pulmonary airway malformation). Radiographics. 31(3):743-8, 2011
                                  2. Farrugia MK et al: Congenital lung lesions: classification and concordance of radiological appearance and surgical pathology. Pediatr Surg Int. 24(9):987-91, 2008
                                  3. Riedlinger WF et al: Bronchial atresia is common to extralobar sequestration, intralobar sequestration, congenital cystic adenomatoid malformation, and lobar emphysema. Pediatr Dev Pathol. 9(5):361-73, 2006
                                  4. Achiron R et al: Fetal lung lesions: a spectrum of disease. New classification based on pathogenesis, two-dimensional and color Doppler ultrasound. Ultrasound Obstet Gynecol. 24(2):107-14, 2004
                                  5. McLean SE et al: Congenital cystic adenomatoid malformation connected to an extralobar pulmonary sequestration in the contralateral chest: common origin? J Pediatr Surg. 39(8):e13-7, 2004
                                  6. Cass DL et al: Cystic lung lesions with systemic arterial blood supply: a hybrid of congenital cystic adenomatoid malformation and bronchopulmonary sequestration. J Pediatr Surg. 32(7):986-90, 1997
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Diagnostic Checklist

                                          TERMINOLOGY

                                          • Synonyms

                                            • Hybrid lesions
                                          • Definitions

                                            • Congenital lung lesion with elements of multiple entities
                                              • Most common is the "hybrid lesion" of congenital pulmonary airway malformation (CPAM) and pulmonary sequestration
                                              • Bronchial atresia may also be associated with CPAM &/or sequestration

                                          IMAGING

                                          • General Features

                                            • Radiographic Findings

                                              • CT Findings

                                                • MR Findings

                                                  • Imaging Recommendations

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • Staging, Grading, & Classification

                                                        • Gross Pathologic & Surgical Features

                                                          CLINICAL ISSUES

                                                          • Presentation

                                                            • Natural History & Prognosis

                                                              • Treatment

                                                                DIAGNOSTIC CHECKLIST

                                                                • Consider

                                                                  Selected References

                                                                  1. Kao SW et al: AIRP best cases in radiologic-pathologic correlation: type 2 congenital cystic adenomatoid malformation (type 2 congenital pulmonary airway malformation). Radiographics. 31(3):743-8, 2011
                                                                  2. Farrugia MK et al: Congenital lung lesions: classification and concordance of radiological appearance and surgical pathology. Pediatr Surg Int. 24(9):987-91, 2008
                                                                  3. Riedlinger WF et al: Bronchial atresia is common to extralobar sequestration, intralobar sequestration, congenital cystic adenomatoid malformation, and lobar emphysema. Pediatr Dev Pathol. 9(5):361-73, 2006
                                                                  4. Achiron R et al: Fetal lung lesions: a spectrum of disease. New classification based on pathogenesis, two-dimensional and color Doppler ultrasound. Ultrasound Obstet Gynecol. 24(2):107-14, 2004
                                                                  5. McLean SE et al: Congenital cystic adenomatoid malformation connected to an extralobar pulmonary sequestration in the contralateral chest: common origin? J Pediatr Surg. 39(8):e13-7, 2004
                                                                  6. Cass DL et al: Cystic lung lesions with systemic arterial blood supply: a hybrid of congenital cystic adenomatoid malformation and bronchopulmonary sequestration. J Pediatr Surg. 32(7):986-90, 1997