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Mixed Connective Tissue Disease
Laura E. Heyneman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Mixed connective tissue disease (MCTD)
              • Synonyms

                • Systemic sclerosis (SS): Scleroderma
              • Definitions

                • MCTD: Overlap syndrome that is distinct clinical entity with features of systemic lupus erythematosus (SLE), SS, rheumatoid arthritis (RA), or dermatomyositis/polymyositis (D/P) and high-titer antibodies to ribonucleoprotein

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. Ahuja J et al: Imaging of pulmonary manifestations of connective tissue diseases. Radiol Clin North Am. 54(6):1015-1031, 2016
                                        2. Gunnarsson R et al: Mixed connective tissue disease. Best Pract Res Clin Rheumatol. 30(1):95-111, 2016
                                        3. Ohno Y et al: State-of-the-art imaging of the lung for connective tissue disease (CTD). Curr Rheumatol Rep. 17(12):69, 2015
                                        4. Ruano CA et al: Thoracic manifestations of connective tissue diseases. Curr Probl Diagn Radiol. 44(1):47-59, 2015
                                        5. Serra G et al: Thoracic involvement in connective tissue diseases: radiological patterns and follow-up. JBR-BTR. 98(1):3-19, 2015
                                        6. Shahane A: Pulmonary hypertension in rheumatic diseases: epidemiology and pathogenesis. Rheumatol Int. 33(7):1655-67, 2013
                                        7. Lynch DA: Lung disease related to collagen vascular disease. J Thorac Imaging. 24(4):299-309, 2009
                                        8. Devaraj A et al: Computed tomographic imaging in connective tissue diseases. Semin Respir Crit Care Med. 28(4):389-97, 2007
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Mixed connective tissue disease (MCTD)
                                                    • Synonyms

                                                      • Systemic sclerosis (SS): Scleroderma
                                                    • Definitions

                                                      • MCTD: Overlap syndrome that is distinct clinical entity with features of systemic lupus erythematosus (SLE), SS, rheumatoid arthritis (RA), or dermatomyositis/polymyositis (D/P) and high-titer antibodies to ribonucleoprotein

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Staging, Grading, & Classification

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. Ahuja J et al: Imaging of pulmonary manifestations of connective tissue diseases. Radiol Clin North Am. 54(6):1015-1031, 2016
                                                                              2. Gunnarsson R et al: Mixed connective tissue disease. Best Pract Res Clin Rheumatol. 30(1):95-111, 2016
                                                                              3. Ohno Y et al: State-of-the-art imaging of the lung for connective tissue disease (CTD). Curr Rheumatol Rep. 17(12):69, 2015
                                                                              4. Ruano CA et al: Thoracic manifestations of connective tissue diseases. Curr Probl Diagn Radiol. 44(1):47-59, 2015
                                                                              5. Serra G et al: Thoracic involvement in connective tissue diseases: radiological patterns and follow-up. JBR-BTR. 98(1):3-19, 2015
                                                                              6. Shahane A: Pulmonary hypertension in rheumatic diseases: epidemiology and pathogenesis. Rheumatol Int. 33(7):1655-67, 2013
                                                                              7. Lynch DA: Lung disease related to collagen vascular disease. J Thorac Imaging. 24(4):299-309, 2009
                                                                              8. Devaraj A et al: Computed tomographic imaging in connective tissue diseases. Semin Respir Crit Care Med. 28(4):389-97, 2007