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Mixed Epithelial and Stromal Tumor Family
Ghaneh Fananapazir, MD, FSAR, FSRU, FSABI; Matthew T. Heller, MD, FSAR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Adult cystic nephroma (ACN)
              • Mixed epithelial and stromal tumor (MEST)
            • Synonyms

              • ACN formerly referred to as cystic nephroma, cystic adenoma of kidney, and multilocular renal cyst
              • MEST formerly referred to as congenital mesoblastic nephroma in adult, adult mesoblastic nephroma, cystic hamartoma of renal pelvis, multilocular renal cyst with ovarian-like stroma, adult mature nephroblastoma, and cystic partially differentiated nephroblastoma
            • Definitions

              • Both ACN and MEST are under MEST family of renal tumors

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      Selected References

                                      1. Magnelli LL et al: A MEST up classification? Review of the re-classification of mixed epithelial and stromal tumor and adult cystic nephroma for the abdominal radiologist. Abdom Radiol (NY). 46(2):696-702, 2021
                                      2. Greco F et al: Ultrasound imaging of cystic nephroma. J Kidney Cancer VHL. 4(3):1-9, 2017
                                      3. Sun BL et al: Cystic nephroma/mixed epithelial stromal tumor: a benign neoplasm with potential for recurrence. Int J Surg Pathol. 23(3):238-42, 2015
                                      4. Wood CG 3rd et al: CT and MR imaging for evaluation of cystic renal lesions and diseases. Radiographics. 35(1):125-41, 2015
                                      5. Zou L et al: Malignant mixed epithelial and stromal tumor of the kidney: the second male case and review of literature. Int J Clin Exp Pathol. 7(5):2658-63, 2014
                                      6. Wang CJ et al: Mixed epithelial and stromal tumor of the kidney: report of eight cases and literature review. World J Surg Oncol. 11(1):207, 2013
                                      7. Wilkinson C et al: Adult multilocular cystic nephroma: report of six cases with clinical, radio-pathologic correlation and review of literature. Urol Ann. 5(1):13-7, 2013
                                      8. Zheng S et al: Mixed epithelial and stromal tumor of the kidney. Kaohsiung J Med Sci. 29(5):280-3, 2013
                                      9. Katabathina VS et al: Cystic renal neoplasms and renal neoplasms associated with cystic renal diseases in adults: cross-sectional imaging findings. J Comput Assist Tomogr. 36(6):659-68, 2012
                                      10. Raman SP et al: Beyond renal cell carcinoma: rare and unusual renal masses. Abdom Imaging. 37(5):873-84, 2012
                                      11. Wood CG 3rd et al: Mixed epithelial and stromal tumor of the kidney. J Urol. 186(2):677-8, 2011
                                      12. Chu LC et al: Mixed epithelial and stromal tumor of the kidney: radiologic-pathologic correlation. Radiographics. 30(6):1541-51, 2010
                                      13. Lang N et al: Mixed epithelial and stromal tumor of the kidney: an analysis of multidetector computed tomography manifestations and clinicopathologic findings. J Comput Assist Tomogr. 34(2):177-81, 2010
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Clinical Issues

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Adult cystic nephroma (ACN)
                                                  • Mixed epithelial and stromal tumor (MEST)
                                                • Synonyms

                                                  • ACN formerly referred to as cystic nephroma, cystic adenoma of kidney, and multilocular renal cyst
                                                  • MEST formerly referred to as congenital mesoblastic nephroma in adult, adult mesoblastic nephroma, cystic hamartoma of renal pelvis, multilocular renal cyst with ovarian-like stroma, adult mature nephroblastoma, and cystic partially differentiated nephroblastoma
                                                • Definitions

                                                  • Both ACN and MEST are under MEST family of renal tumors

                                                IMAGING

                                                • General Features

                                                  • CT Findings

                                                    • MR Findings

                                                      • Ultrasonographic Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          Selected References

                                                                          1. Magnelli LL et al: A MEST up classification? Review of the re-classification of mixed epithelial and stromal tumor and adult cystic nephroma for the abdominal radiologist. Abdom Radiol (NY). 46(2):696-702, 2021
                                                                          2. Greco F et al: Ultrasound imaging of cystic nephroma. J Kidney Cancer VHL. 4(3):1-9, 2017
                                                                          3. Sun BL et al: Cystic nephroma/mixed epithelial stromal tumor: a benign neoplasm with potential for recurrence. Int J Surg Pathol. 23(3):238-42, 2015
                                                                          4. Wood CG 3rd et al: CT and MR imaging for evaluation of cystic renal lesions and diseases. Radiographics. 35(1):125-41, 2015
                                                                          5. Zou L et al: Malignant mixed epithelial and stromal tumor of the kidney: the second male case and review of literature. Int J Clin Exp Pathol. 7(5):2658-63, 2014
                                                                          6. Wang CJ et al: Mixed epithelial and stromal tumor of the kidney: report of eight cases and literature review. World J Surg Oncol. 11(1):207, 2013
                                                                          7. Wilkinson C et al: Adult multilocular cystic nephroma: report of six cases with clinical, radio-pathologic correlation and review of literature. Urol Ann. 5(1):13-7, 2013
                                                                          8. Zheng S et al: Mixed epithelial and stromal tumor of the kidney. Kaohsiung J Med Sci. 29(5):280-3, 2013
                                                                          9. Katabathina VS et al: Cystic renal neoplasms and renal neoplasms associated with cystic renal diseases in adults: cross-sectional imaging findings. J Comput Assist Tomogr. 36(6):659-68, 2012
                                                                          10. Raman SP et al: Beyond renal cell carcinoma: rare and unusual renal masses. Abdom Imaging. 37(5):873-84, 2012
                                                                          11. Wood CG 3rd et al: Mixed epithelial and stromal tumor of the kidney. J Urol. 186(2):677-8, 2011
                                                                          12. Chu LC et al: Mixed epithelial and stromal tumor of the kidney: radiologic-pathologic correlation. Radiographics. 30(6):1541-51, 2010
                                                                          13. Lang N et al: Mixed epithelial and stromal tumor of the kidney: an analysis of multidetector computed tomography manifestations and clinicopathologic findings. J Comput Assist Tomogr. 34(2):177-81, 2010