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mRECIST
Brett W. Carter, MD
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KEY FACTS

  • Terminology

    • Imaging Anatomy

      • Clinical Implications

        TERMINOLOGY

        • Abbreviations

          • Modified Response Criteria in Solid Tumors (mRECIST)
        • Definitions

          • Modified response criteria created to assess treatment response in malignant pleural mesothelioma (MPM)
            • Developed in response to belief that RECIST 1.1 does not address unique shape and growth of MPM and could lead to inaccurate measurements
        • Key Concepts

          • Unidimensional measurements of pleural thickness obtained
            • Perpendicular to chest wall or mediastinum
            • Measured in 2 sites at 3 different levels on axial CT
              • Addition of 6 specific measurements: 1 univariate diameter
          • Measurement of lymph nodes and other lesions
            • Selected according to RECIST 1.1 criteria
            • Unidimensional measurements obtained
          • Total tumor burden: Addition of all measurements

        IMAGING ANATOMY

        • Baseline Measurement Guidelines

          • Imaging Parameters

            CLINICAL IMPLICATIONS

            • Reassessment

              • Evaluation of Overall Response

                Selected References

                1. Tsao AS et al: A practical guide of the Southwest Oncology Group to measure malignant pleural mesothelioma tumors by RECIST and modified RECIST criteria. J Thorac Oncol. 6(3):598-601, 2011
                2. Ak G et al: Three-dimensional evaluation of chemotherapy response in malignant pleural mesothelioma. Eur J Radiol. 74(1):130-5, 2010
                3. Liu F et al: Assessment of therapy responses and prediction of survival in malignant pleural mesothelioma through computer-aided volumetric measurement on computed tomography scans. J Thorac Oncol. 5(6):879-84, 2010
                4. Plathow C et al: Therapy response in malignant pleural mesothelioma-role of MRI using RECIST, modified RECIST and volumetric approaches in comparison with CT. Eur Radiol. 18(8):1635-43, 2008
                5. Ceresoli GL et al: Assessment of tumor response in malignant pleural mesothelioma. Cancer Treat Rev. 33(6):533-41, 2007
                6. Nowak AK: CT, RECIST, and malignant pleural mesothelioma. Lung Cancer. 49 Suppl 1:S37-40, 2005
                7. Byrne MJ et al: Modified RECIST criteria for assessment of response in malignant pleural mesothelioma. Ann Oncol. 15(2):257-60, 2004
                8. van Klaveren RJ et al: Inadequacy of the RECIST criteria for response evaluation in patients with malignant pleural mesothelioma. Lung Cancer. 43(1):63-9, 2004
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                References
                Tables

                Tables

                KEY FACTS

                • Terminology

                  • Imaging Anatomy

                    • Clinical Implications

                      TERMINOLOGY

                      • Abbreviations

                        • Modified Response Criteria in Solid Tumors (mRECIST)
                      • Definitions

                        • Modified response criteria created to assess treatment response in malignant pleural mesothelioma (MPM)
                          • Developed in response to belief that RECIST 1.1 does not address unique shape and growth of MPM and could lead to inaccurate measurements
                      • Key Concepts

                        • Unidimensional measurements of pleural thickness obtained
                          • Perpendicular to chest wall or mediastinum
                          • Measured in 2 sites at 3 different levels on axial CT
                            • Addition of 6 specific measurements: 1 univariate diameter
                        • Measurement of lymph nodes and other lesions
                          • Selected according to RECIST 1.1 criteria
                          • Unidimensional measurements obtained
                        • Total tumor burden: Addition of all measurements

                      IMAGING ANATOMY

                      • Baseline Measurement Guidelines

                        • Imaging Parameters

                          CLINICAL IMPLICATIONS

                          • Reassessment

                            • Evaluation of Overall Response

                              Selected References

                              1. Tsao AS et al: A practical guide of the Southwest Oncology Group to measure malignant pleural mesothelioma tumors by RECIST and modified RECIST criteria. J Thorac Oncol. 6(3):598-601, 2011
                              2. Ak G et al: Three-dimensional evaluation of chemotherapy response in malignant pleural mesothelioma. Eur J Radiol. 74(1):130-5, 2010
                              3. Liu F et al: Assessment of therapy responses and prediction of survival in malignant pleural mesothelioma through computer-aided volumetric measurement on computed tomography scans. J Thorac Oncol. 5(6):879-84, 2010
                              4. Plathow C et al: Therapy response in malignant pleural mesothelioma-role of MRI using RECIST, modified RECIST and volumetric approaches in comparison with CT. Eur Radiol. 18(8):1635-43, 2008
                              5. Ceresoli GL et al: Assessment of tumor response in malignant pleural mesothelioma. Cancer Treat Rev. 33(6):533-41, 2007
                              6. Nowak AK: CT, RECIST, and malignant pleural mesothelioma. Lung Cancer. 49 Suppl 1:S37-40, 2005
                              7. Byrne MJ et al: Modified RECIST criteria for assessment of response in malignant pleural mesothelioma. Ann Oncol. 15(2):257-60, 2004
                              8. van Klaveren RJ et al: Inadequacy of the RECIST criteria for response evaluation in patients with malignant pleural mesothelioma. Lung Cancer. 43(1):63-9, 2004