Rare, unilocular or multilocular, cystic epithelial tumor with goblet cells and subepithelial, ovarian-like stroma
IMAGING
General Features
Ultrasonographic Findings
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Boyum JH et al: Hepatic mucinous cystic neoplasm versus simple biliary cyst: assessment of distinguishing imaging features using CT and MRI. AJR Am J Roentgenol. 216(2):403-11, 2021
Budkule DP et al: Infrequent intrahepatic cystic neoplasm: dilemmas in diagnosis and management. BMJ Case Rep. 12(5), 2019
Kovacs MD et al: Differentiating biliary cystadenomas from benign hepatic cysts: preliminary analysis of new predictive imaging features. Clin Imaging. 49:44-7, 2018
Kunovsky L et al: Mucinous cystic neoplasm of the liver or intraductal papillary mucinous neoplasm of the bile duct? A case report and a review of literature. Ann Hepatol. 17(3):519-24, 2018
Lee DH et al: Primary malignant tumours in the non-cirrhotic liver. Eur J Radiol. 95:349-61, 2017
Arnaoutakis DJ et al: Management of biliary cystic tumors: a multi-institutional analysis of a rare liver tumor. Ann Surg. 261(2):361-7, 2015
Chen YW et al: Surgical management of biliary cystadenoma and cystadenocarcinoma of the liver. Genet Mol Res. 13(3):6383-90, 2014
Cogley JR et al: MR imaging of benign focal liver lesions. Radiol Clin North Am. 52(4):657-82, 2014
Kubota K et al: Clinicopathological features and prognosis of mucin-producing bile duct tumor and mucinous cystic tumor of the liver: a multi-institutional study by the Japan Biliary Association. J Hepatobiliary Pancreat Sci. 21(3):176-85, 2014
Soares KC et al: Cystic neoplasms of the liver: biliary cystadenoma and cystadenocarcinoma. J Am Coll Surg. 218(1):119-28, 2014
Zen Y et al: Intraductal papillary neoplasms and mucinous cystic neoplasms of the hepatobiliary system: demographic differences between Asian and Western populations, and comparison with pancreatic counterparts. Histopathology. 65(2):164-73, 2014
Bakoyiannis A et al: Rare cystic liver lesions: a diagnostic and managing challenge. World J Gastroenterol. 19(43):7603-19, 2013
Lantinga MA et al: Evaluation of hepatic cystic lesions. World J Gastroenterol. 19(23):3543-54, 2013
Macedo FI: Current management of noninfectious hepatic cystic lesions: a review of the literature. World J Hepatol. 5(9):462-9, 2013
Qian LJ et al: Spectrum of multilocular cystic hepatic lesions: CT and MR imaging findings with pathologic correlation. Radiographics. 33(5):1419-33, 2013
Xu HX et al: Imaging features of intrahepatic biliary cystadenoma and cystadenocarcinoma on B-mode and contrast-enhanced ultrasound. Ultraschall Med. 33(7):E241-9, 2012
Emre A et al: Intrahepatic biliary cystic neoplasms: surgical results of 9 patients and literature review. World J Gastroenterol. 17(3):361-5, 2011
Choi HK et al: Differential diagnosis for intrahepatic biliary cystadenoma and hepatic simple cyst: significance of cystic fluid analysis and radiologic findings. J Clin Gastroenterol. 44(4):289-93, 2010
Bosman FT et al: World Health Organization classification of tumours. Pathology and genetics of tumours of the digestive system. IARC Press, 2010
Seo JK et al: Appropriate diagnosis of biliary cystic tumors: comparison with atypical hepatic simple cysts. Eur J Gastroenterol Hepatol. 22(8):989-96, 2010
Lam MM et al: Ovarian-type stroma in hepatobiliary cystadenomas and pancreatic mucinous cystic neoplasms: an immunohistochemical study. Am J Clin Pathol. 129(2):211-8, 2008
Pojchamarnwiputh S et al: Computed tomography of biliary cystadenoma and biliary cystadenocarcinoma. Singapore Med J. 49(5):392-6, 2008
Abdul-Al HM et al: Expression of estrogen and progesterone receptors and inhibin-alpha in hepatobiliary cystadenoma: an immunohistochemical study. Virchows Arch. 450(6):691-7, 2007
Lewin M et al: Assessment of MRI and MRCP in diagnosis of biliary cystadenoma and cystadenocarcinoma. Eur Radiol. 16(2):407-13, 2006
Teoh AY et al: Biliary cystadenoma and other complicated cystic lesions of the liver: diagnostic and therapeutic challenges. World J Surg. 30(8):1560-6, 2006
Buetow PC et al: Biliary cystadenoma and cystadenocarcinoma: clinical-imaging-pathologic correlations with emphasis on the importance of ovarian stroma. Radiology. 196(3):805-10, 1995
Devaney K et al: Hepatobiliary cystadenoma and cystadenocarcinoma. A light microscopic and immunohistochemical study of 70 patients. Am J Surg Pathol 18:1078, 1994
Korobkin M et al: Biliary cystadenoma and cystadenocarcinoma: CT and sonographic findings. AJR Am J Roentgenol. 153(3):507-11, 1989
Rare, unilocular or multilocular, cystic epithelial tumor with goblet cells and subepithelial, ovarian-like stroma
IMAGING
General Features
Ultrasonographic Findings
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Boyum JH et al: Hepatic mucinous cystic neoplasm versus simple biliary cyst: assessment of distinguishing imaging features using CT and MRI. AJR Am J Roentgenol. 216(2):403-11, 2021
Budkule DP et al: Infrequent intrahepatic cystic neoplasm: dilemmas in diagnosis and management. BMJ Case Rep. 12(5), 2019
Kovacs MD et al: Differentiating biliary cystadenomas from benign hepatic cysts: preliminary analysis of new predictive imaging features. Clin Imaging. 49:44-7, 2018
Kunovsky L et al: Mucinous cystic neoplasm of the liver or intraductal papillary mucinous neoplasm of the bile duct? A case report and a review of literature. Ann Hepatol. 17(3):519-24, 2018
Lee DH et al: Primary malignant tumours in the non-cirrhotic liver. Eur J Radiol. 95:349-61, 2017
Arnaoutakis DJ et al: Management of biliary cystic tumors: a multi-institutional analysis of a rare liver tumor. Ann Surg. 261(2):361-7, 2015
Chen YW et al: Surgical management of biliary cystadenoma and cystadenocarcinoma of the liver. Genet Mol Res. 13(3):6383-90, 2014
Cogley JR et al: MR imaging of benign focal liver lesions. Radiol Clin North Am. 52(4):657-82, 2014
Kubota K et al: Clinicopathological features and prognosis of mucin-producing bile duct tumor and mucinous cystic tumor of the liver: a multi-institutional study by the Japan Biliary Association. J Hepatobiliary Pancreat Sci. 21(3):176-85, 2014
Soares KC et al: Cystic neoplasms of the liver: biliary cystadenoma and cystadenocarcinoma. J Am Coll Surg. 218(1):119-28, 2014
Zen Y et al: Intraductal papillary neoplasms and mucinous cystic neoplasms of the hepatobiliary system: demographic differences between Asian and Western populations, and comparison with pancreatic counterparts. Histopathology. 65(2):164-73, 2014
Bakoyiannis A et al: Rare cystic liver lesions: a diagnostic and managing challenge. World J Gastroenterol. 19(43):7603-19, 2013
Lantinga MA et al: Evaluation of hepatic cystic lesions. World J Gastroenterol. 19(23):3543-54, 2013
Macedo FI: Current management of noninfectious hepatic cystic lesions: a review of the literature. World J Hepatol. 5(9):462-9, 2013
Qian LJ et al: Spectrum of multilocular cystic hepatic lesions: CT and MR imaging findings with pathologic correlation. Radiographics. 33(5):1419-33, 2013
Xu HX et al: Imaging features of intrahepatic biliary cystadenoma and cystadenocarcinoma on B-mode and contrast-enhanced ultrasound. Ultraschall Med. 33(7):E241-9, 2012
Emre A et al: Intrahepatic biliary cystic neoplasms: surgical results of 9 patients and literature review. World J Gastroenterol. 17(3):361-5, 2011
Choi HK et al: Differential diagnosis for intrahepatic biliary cystadenoma and hepatic simple cyst: significance of cystic fluid analysis and radiologic findings. J Clin Gastroenterol. 44(4):289-93, 2010
Bosman FT et al: World Health Organization classification of tumours. Pathology and genetics of tumours of the digestive system. IARC Press, 2010
Seo JK et al: Appropriate diagnosis of biliary cystic tumors: comparison with atypical hepatic simple cysts. Eur J Gastroenterol Hepatol. 22(8):989-96, 2010
Lam MM et al: Ovarian-type stroma in hepatobiliary cystadenomas and pancreatic mucinous cystic neoplasms: an immunohistochemical study. Am J Clin Pathol. 129(2):211-8, 2008
Pojchamarnwiputh S et al: Computed tomography of biliary cystadenoma and biliary cystadenocarcinoma. Singapore Med J. 49(5):392-6, 2008
Abdul-Al HM et al: Expression of estrogen and progesterone receptors and inhibin-alpha in hepatobiliary cystadenoma: an immunohistochemical study. Virchows Arch. 450(6):691-7, 2007
Lewin M et al: Assessment of MRI and MRCP in diagnosis of biliary cystadenoma and cystadenocarcinoma. Eur Radiol. 16(2):407-13, 2006
Teoh AY et al: Biliary cystadenoma and other complicated cystic lesions of the liver: diagnostic and therapeutic challenges. World J Surg. 30(8):1560-6, 2006
Buetow PC et al: Biliary cystadenoma and cystadenocarcinoma: clinical-imaging-pathologic correlations with emphasis on the importance of ovarian stroma. Radiology. 196(3):805-10, 1995
Devaney K et al: Hepatobiliary cystadenoma and cystadenocarcinoma. A light microscopic and immunohistochemical study of 70 patients. Am J Surg Pathol 18:1078, 1994
Korobkin M et al: Biliary cystadenoma and cystadenocarcinoma: CT and sonographic findings. AJR Am J Roentgenol. 153(3):507-11, 1989
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