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KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
- Mucinous cystic neoplasm (MCN), mucinous macrocystic neoplasm or adenoma, mucinous cystadenoma or cystadenocarcinoma
Definitions
- Thick-walled, unilocular or multilocular pancreatic tumor composed of large, mucin-containing cysts
- Some sources suggest presence of ovarian stroma within lesion is necessary for diagnosis
- MCN and intraductal papillary mucinous neoplasm (IPMN) are together classified as pancreatic mucinous tumors
- Thick-walled, unilocular or multilocular pancreatic tumor composed of large, mucin-containing cysts
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Angiographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Goh BKP et al: Changing trends in the clinicopathological features, practices and outcomes in the surgical management for cystic lesions of the pancreas and impact of the international guidelines: Single institution experience with 462 cases between 1995-2018. Pancreatology. 20(8):1786-90, 2020
- Guo Y et al: Sonographic characteristics and follow-up of pancreatic cysts. J Clin Ultrasound. 49(3):184-8, 2020
- Mamone G et al: MRI of mucinous pancreatic cystic lesions: a new updated morphological approach for the differential diagnosis. Updates Surg. 72(3):617-37, 2020
- Vaalavuo Y et al: The European evidence-based guidelines on pancreatic cystic neoplasms (PCN) in clinical practice: The development of relative and absolute indications for surgery during prospective IPMN surveillance. Pancreatology. 20(7):1393-8, 2020
- Yadav RK et al: Differentiating benign from malignant pancreatic cysts on computed tomography. Eur J Radiol Open. 7:100278, 2020
- Hasan A et al: Overview and comparison of guidelines for management of pancreatic cystic neoplasms. World J Gastroenterol. 25(31):4405-13, 2019
- Elta GH et al: ACG clinical guideline: diagnosis and management of pancreatic cysts. Am J Gastroenterol. 113(4):464-79, 2018
- European study group on cystic tumours of the pancreas.: european evidence-based guidelines on pancreatic cystic neoplasms. Gut. 67(5):789-804, 2018
- Megibow AJ et al: Management of incidental pancreatic cysts: a white paper of the ACR incidental findings committee. J Am Coll Radiol. 14(7):911-23, 2017
- Vege SS et al: American gastroenterological association institute guideline on the diagnosis and management of asymptomatic neoplastic pancreatic cysts. Gastroenterology. 148(4):819-22; quize12-3, 2015
- Park JW et al: Mucinous cystic neoplasm of the pancreas: is surgical resection recommended for all surgically fit patients? Pancreatology. 14(2):131-6, 2014
- Pinho DF et al: Incidental pancreatic cysts: role of magnetic resonance imaging. Top Magn Reson Imaging. 23(2):117-28, 2014
- Farrell JJ et al: Pancreatic cystic neoplasms: management and unanswered questions. Gastroenterology. 144(6):1303-15, 2013
- Gil E et al: Mucinous cystic neoplasms of the pancreas with ovarian stroma. ANZ J Surg. 83(12):985-90, 2013
- Dewhurst CE et al: Cystic tumors of the pancreas: imaging and management. Radiol Clin North Am. 50(3):467-86, 2012
- Hong SK et al: Targeted cyst wall puncture and aspiration during EUS-FNA increases the diagnostic yield of premalignant and malignant pancreatic cysts. Gastrointest Endosc. 75(4):775-82, 2012
- Kucera JN et al: Cystic lesions of the pancreas: radiologic-endosonographic correlation. Radiographics. 32(7):E283-301, 2012
- Mottola JC et al: Diffusion-weighted MRI of focal cystic pancreatic lesions at 3.0-Tesla: preliminary results. Abdom Imaging. 37(1):110-7, 2012
- Valsangkar NP et al: 851 resected cystic tumors of the pancreas: a 33-year experience at the Massachusetts General Hospital. Surgery. 152(3 Suppl 1):S4-12, 2012
- Bang JY et al: Mucinous cystic neoplasm of the pancreas. Clin Gastroenterol Hepatol. 9(8):e80-1, 2011
- Le Baleur Y et al: Mucinous cystic neoplasms of the pancreas: definition of preoperative imaging criteria for high-risk lesions. Pancreatology. 11(5):495-9, 2011
- Sakorafas GH et al: Primary pancreatic cystic neoplasms revisited: part II. Mucinous cystic neoplasms. Surg Oncol. 20(2):e93-101, 2011
- Basturk O et al: Pancreatic cysts: pathologic classification, differential diagnosis, and clinical implications. Arch Pathol Lab Med. 133(3):423-38, 2009
- Goh BK et al: A review of mucinous cystic neoplasms of the pancreas defined by ovarian-type stroma: clinicopathological features of 344 patients. World J Surg. 30(12):2236-45, 2006
- Goh BK et al: Pancreatic serous oligocystic adenomas: clinicopathologic features and a comparison with serous microcystic adenomas and mucinous cystic neoplasms. World J Surg. 30(8):1553-9, 2006
- Kim SY et al: Macrocystic neoplasms of the pancreas: CT differentiation of serous oligocystic adenoma from mucinous cystadenoma and intraductal papillary mucinous tumor. AJR Am J Roentgenol. 187(5):1192-8, 2006
- Takeshita K et al: Unusual imaging appearances of pancreatic serous cystadenoma: correlation with surgery and pathologic analysis. Abdom Imaging. 30(5):610-5, 2005
- O'Toole D et al: Macrocystic pancreatic cystadenoma: The role of EUS and cyst fluid analysis in distinguishing mucinous and serous lesions. Gastrointest Endosc. 59(7):823-9, 2004
- Hara T et al: Mucinous cystic tumors of the pancreas. Surg Today. 32(11):965-9, 2002
- Maire F et al: Benign inflammatory pancreatic mucinous cystadenomas mimicking locally advanced cystadenocarcinomas. Presentation of 3 cases. Pancreatology. 2(1):74-8, 2002
- Oshikawa O et al: Dynamic sonography of pancreatic tumors: comparison with dynamic CT. AJR Am J Roentgenol. 178(5):1133-7, 2002
- Balci NC et al: Radiologic features of cystic, endocrine and other pancreatic neoplasms. Eur J Radiol. 38(2):113-9, 2001
- Friedman AC et al: CT of primary cystic pancreatic neoplasms: nihilism may be unwarranted. AJR Am J Roentgenol. 177(2):469-70, 2001
- Grogan JR et al: Making sense of mucin-producing pancreatic tumors. AJR Am J Roentgenol. 176(4):921-9, 2001
- Megibow AJ et al: Cystic pancreatic masses: cross-sectional imaging observations and serial follow-up. Abdom Imaging. 26(6):640-7, 2001
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
- Mucinous cystic neoplasm (MCN), mucinous macrocystic neoplasm or adenoma, mucinous cystadenoma or cystadenocarcinoma
Definitions
- Thick-walled, unilocular or multilocular pancreatic tumor composed of large, mucin-containing cysts
- Some sources suggest presence of ovarian stroma within lesion is necessary for diagnosis
- MCN and intraductal papillary mucinous neoplasm (IPMN) are together classified as pancreatic mucinous tumors
- Thick-walled, unilocular or multilocular pancreatic tumor composed of large, mucin-containing cysts
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Angiographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Goh BKP et al: Changing trends in the clinicopathological features, practices and outcomes in the surgical management for cystic lesions of the pancreas and impact of the international guidelines: Single institution experience with 462 cases between 1995-2018. Pancreatology. 20(8):1786-90, 2020
- Guo Y et al: Sonographic characteristics and follow-up of pancreatic cysts. J Clin Ultrasound. 49(3):184-8, 2020
- Mamone G et al: MRI of mucinous pancreatic cystic lesions: a new updated morphological approach for the differential diagnosis. Updates Surg. 72(3):617-37, 2020
- Vaalavuo Y et al: The European evidence-based guidelines on pancreatic cystic neoplasms (PCN) in clinical practice: The development of relative and absolute indications for surgery during prospective IPMN surveillance. Pancreatology. 20(7):1393-8, 2020
- Yadav RK et al: Differentiating benign from malignant pancreatic cysts on computed tomography. Eur J Radiol Open. 7:100278, 2020
- Hasan A et al: Overview and comparison of guidelines for management of pancreatic cystic neoplasms. World J Gastroenterol. 25(31):4405-13, 2019
- Elta GH et al: ACG clinical guideline: diagnosis and management of pancreatic cysts. Am J Gastroenterol. 113(4):464-79, 2018
- European study group on cystic tumours of the pancreas.: european evidence-based guidelines on pancreatic cystic neoplasms. Gut. 67(5):789-804, 2018
- Megibow AJ et al: Management of incidental pancreatic cysts: a white paper of the ACR incidental findings committee. J Am Coll Radiol. 14(7):911-23, 2017
- Vege SS et al: American gastroenterological association institute guideline on the diagnosis and management of asymptomatic neoplastic pancreatic cysts. Gastroenterology. 148(4):819-22; quize12-3, 2015
- Park JW et al: Mucinous cystic neoplasm of the pancreas: is surgical resection recommended for all surgically fit patients? Pancreatology. 14(2):131-6, 2014
- Pinho DF et al: Incidental pancreatic cysts: role of magnetic resonance imaging. Top Magn Reson Imaging. 23(2):117-28, 2014
- Farrell JJ et al: Pancreatic cystic neoplasms: management and unanswered questions. Gastroenterology. 144(6):1303-15, 2013
- Gil E et al: Mucinous cystic neoplasms of the pancreas with ovarian stroma. ANZ J Surg. 83(12):985-90, 2013
- Dewhurst CE et al: Cystic tumors of the pancreas: imaging and management. Radiol Clin North Am. 50(3):467-86, 2012
- Hong SK et al: Targeted cyst wall puncture and aspiration during EUS-FNA increases the diagnostic yield of premalignant and malignant pancreatic cysts. Gastrointest Endosc. 75(4):775-82, 2012
- Kucera JN et al: Cystic lesions of the pancreas: radiologic-endosonographic correlation. Radiographics. 32(7):E283-301, 2012
- Mottola JC et al: Diffusion-weighted MRI of focal cystic pancreatic lesions at 3.0-Tesla: preliminary results. Abdom Imaging. 37(1):110-7, 2012
- Valsangkar NP et al: 851 resected cystic tumors of the pancreas: a 33-year experience at the Massachusetts General Hospital. Surgery. 152(3 Suppl 1):S4-12, 2012
- Bang JY et al: Mucinous cystic neoplasm of the pancreas. Clin Gastroenterol Hepatol. 9(8):e80-1, 2011
- Le Baleur Y et al: Mucinous cystic neoplasms of the pancreas: definition of preoperative imaging criteria for high-risk lesions. Pancreatology. 11(5):495-9, 2011
- Sakorafas GH et al: Primary pancreatic cystic neoplasms revisited: part II. Mucinous cystic neoplasms. Surg Oncol. 20(2):e93-101, 2011
- Basturk O et al: Pancreatic cysts: pathologic classification, differential diagnosis, and clinical implications. Arch Pathol Lab Med. 133(3):423-38, 2009
- Goh BK et al: A review of mucinous cystic neoplasms of the pancreas defined by ovarian-type stroma: clinicopathological features of 344 patients. World J Surg. 30(12):2236-45, 2006
- Goh BK et al: Pancreatic serous oligocystic adenomas: clinicopathologic features and a comparison with serous microcystic adenomas and mucinous cystic neoplasms. World J Surg. 30(8):1553-9, 2006
- Kim SY et al: Macrocystic neoplasms of the pancreas: CT differentiation of serous oligocystic adenoma from mucinous cystadenoma and intraductal papillary mucinous tumor. AJR Am J Roentgenol. 187(5):1192-8, 2006
- Takeshita K et al: Unusual imaging appearances of pancreatic serous cystadenoma: correlation with surgery and pathologic analysis. Abdom Imaging. 30(5):610-5, 2005
- O'Toole D et al: Macrocystic pancreatic cystadenoma: The role of EUS and cyst fluid analysis in distinguishing mucinous and serous lesions. Gastrointest Endosc. 59(7):823-9, 2004
- Hara T et al: Mucinous cystic tumors of the pancreas. Surg Today. 32(11):965-9, 2002
- Maire F et al: Benign inflammatory pancreatic mucinous cystadenomas mimicking locally advanced cystadenocarcinomas. Presentation of 3 cases. Pancreatology. 2(1):74-8, 2002
- Oshikawa O et al: Dynamic sonography of pancreatic tumors: comparison with dynamic CT. AJR Am J Roentgenol. 178(5):1133-7, 2002
- Balci NC et al: Radiologic features of cystic, endocrine and other pancreatic neoplasms. Eur J Radiol. 38(2):113-9, 2001
- Friedman AC et al: CT of primary cystic pancreatic neoplasms: nihilism may be unwarranted. AJR Am J Roentgenol. 177(2):469-70, 2001
- Grogan JR et al: Making sense of mucin-producing pancreatic tumors. AJR Am J Roentgenol. 176(4):921-9, 2001
- Megibow AJ et al: Cystic pancreatic masses: cross-sectional imaging observations and serial follow-up. Abdom Imaging. 26(6):640-7, 2001
