link
Bookmarks
Multiple Bilateral Similar Findings
Wendie A. Berg, MD, PhD, FACR, FSBI
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Subscribe
0
14
4
0

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Definitions

              • At least 3 total findings with at least 1 in each breast
                • BI-RADS 2 assessment validated for multiple bilateral, mostly (≥ 75%) circumscribed, partially obscured masses on mammography
                  • Suggests benign etiology: Cysts ± fibroadenomas
                  • Excludes palpable findings
                  • Not applicable when there is dominant mass or suspicious finding(s)
                • Preliminary prospective validation also on screening US for solid, circumscribed, oval masses with no suspicious features
              • Multiplicity and bilaterality favor benign etiology
                • May be relevant to other findings and modalities; requires further validation

            IMAGING

            • General Features

              • Mammographic Findings

                • Ultrasonographic Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        CLINICAL ISSUES

                        • Presentation

                          • Demographics

                            • Treatment

                              DIAGNOSTIC CHECKLIST

                              • Image Interpretation Pearls

                                • Reporting Tips

                                  Selected References

                                  1. Oligane HC et al: Grouped amorphous calcifications at mammography: frequently atypical but rarely associated with aggressive malignancy. Radiology. 288(3):671-9, 2018
                                  2. Kamal RM et al: Can we apply the MRI BI-RADS lexicon morphology descriptors on contrast-enhanced spectral mammography? Br J Radiol. 20160157, 2016
                                  3. Kaur N et al: Bilateral florid juvenile fibroadenomas of the breast in an adolescent: a rare indication for subcutaneous mastectomy. J Pediatr Adolesc Gynecol. 28(5):e135-7, 2015
                                  4. Song SE et al: Undiagnosed breast cancer: features at supplemental screening US. Radiology. 277(2):372-80, 2015
                                  5. Park VY et al: Additional malignant breast lesions detected on second-look US after breast MRI vs. additional malignant lesions detected on initial US in breast cancer patients: comparison of US characteristics. Ultraschall Med. 35(5):432-9, 2014
                                  6. Berg WA et al: Multiple bilateral circumscribed masses at screening breast US: consider annual follow-up. Radiology. 268(3):673-83, 2013
                                  7. Berg WA: Screening breast ultrasound in high-risk women: ACRIN 6666 protocol. www.acrin.org/current protocols/6666. Accessed June 26, 2013
                                  8. Berg WA et al: Cystic breast masses and the ACRIN 6666 experience. Radiol Clin North Am. 48(5):931-87, 2010
                                  9. Burnside ES et al: Use of microcalcification descriptors in BI-RADS 4th edition to stratify risk of malignancy. Radiology. 242(2):388-95, 2007
                                  10. Berg WA et al: Operator dependence of physician-performed whole-breast US: lesion detection and characterization. Radiology. 241(2):355-65, 2006
                                  11. Berg WA: Breast US: Benign and probably benign lesions. In SA Feig: 2005 Syllabus, Categorical Course in Diagnostic Radiology: Breast Imaging. Oak Brook: Radiologic Society of North America.115-24, 2005
                                  12. Graf O et al: Follow-up of palpable circumscribed noncalcified solid breast masses at mammography and US: can biopsy be averted? Radiology. 233(3):850-6, 2004
                                  13. Gordon PB et al: Solid breast masses diagnosed as fibroadenoma at fine-needle aspiration biopsy: acceptable rates of growth at long-term follow-up. Radiology. 229(1):233-8, 2003
                                  14. Berg WA et al: Biopsy of amorphous breast calcifications: pathologic outcome and yield at stereotactic biopsy. Radiology. 221(2):495-503, 2001
                                  15. Lamb PM et al: Correlation between ultrasound characteristics, mammographic findings and histological grade in patients with invasive ductal carcinoma of the breast. Clin Radiol. 55(1):40-4, 2000
                                  16. Leung JW et al: Multiple bilateral masses detected on screening mammography: assessment of need for recall imaging. AJR Am J Roentgenol. 175(1):23-9, 2000
                                  Related Anatomy
                                  Loading...
                                  Related Differential Diagnoses
                                  Loading...
                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Clinical Issues

                                          • Diagnostic Checklist

                                            TERMINOLOGY

                                            • Definitions

                                              • At least 3 total findings with at least 1 in each breast
                                                • BI-RADS 2 assessment validated for multiple bilateral, mostly (≥ 75%) circumscribed, partially obscured masses on mammography
                                                  • Suggests benign etiology: Cysts ± fibroadenomas
                                                  • Excludes palpable findings
                                                  • Not applicable when there is dominant mass or suspicious finding(s)
                                                • Preliminary prospective validation also on screening US for solid, circumscribed, oval masses with no suspicious features
                                              • Multiplicity and bilaterality favor benign etiology
                                                • May be relevant to other findings and modalities; requires further validation

                                            IMAGING

                                            • General Features

                                              • Mammographic Findings

                                                • Ultrasonographic Findings

                                                  • MR Findings

                                                    • Imaging Recommendations

                                                      DIFFERENTIAL DIAGNOSIS

                                                        CLINICAL ISSUES

                                                        • Presentation

                                                          • Demographics

                                                            • Treatment

                                                              DIAGNOSTIC CHECKLIST

                                                              • Image Interpretation Pearls

                                                                • Reporting Tips

                                                                  Selected References

                                                                  1. Oligane HC et al: Grouped amorphous calcifications at mammography: frequently atypical but rarely associated with aggressive malignancy. Radiology. 288(3):671-9, 2018
                                                                  2. Kamal RM et al: Can we apply the MRI BI-RADS lexicon morphology descriptors on contrast-enhanced spectral mammography? Br J Radiol. 20160157, 2016
                                                                  3. Kaur N et al: Bilateral florid juvenile fibroadenomas of the breast in an adolescent: a rare indication for subcutaneous mastectomy. J Pediatr Adolesc Gynecol. 28(5):e135-7, 2015
                                                                  4. Song SE et al: Undiagnosed breast cancer: features at supplemental screening US. Radiology. 277(2):372-80, 2015
                                                                  5. Park VY et al: Additional malignant breast lesions detected on second-look US after breast MRI vs. additional malignant lesions detected on initial US in breast cancer patients: comparison of US characteristics. Ultraschall Med. 35(5):432-9, 2014
                                                                  6. Berg WA et al: Multiple bilateral circumscribed masses at screening breast US: consider annual follow-up. Radiology. 268(3):673-83, 2013
                                                                  7. Berg WA: Screening breast ultrasound in high-risk women: ACRIN 6666 protocol. www.acrin.org/current protocols/6666. Accessed June 26, 2013
                                                                  8. Berg WA et al: Cystic breast masses and the ACRIN 6666 experience. Radiol Clin North Am. 48(5):931-87, 2010
                                                                  9. Burnside ES et al: Use of microcalcification descriptors in BI-RADS 4th edition to stratify risk of malignancy. Radiology. 242(2):388-95, 2007
                                                                  10. Berg WA et al: Operator dependence of physician-performed whole-breast US: lesion detection and characterization. Radiology. 241(2):355-65, 2006
                                                                  11. Berg WA: Breast US: Benign and probably benign lesions. In SA Feig: 2005 Syllabus, Categorical Course in Diagnostic Radiology: Breast Imaging. Oak Brook: Radiologic Society of North America.115-24, 2005
                                                                  12. Graf O et al: Follow-up of palpable circumscribed noncalcified solid breast masses at mammography and US: can biopsy be averted? Radiology. 233(3):850-6, 2004
                                                                  13. Gordon PB et al: Solid breast masses diagnosed as fibroadenoma at fine-needle aspiration biopsy: acceptable rates of growth at long-term follow-up. Radiology. 229(1):233-8, 2003
                                                                  14. Berg WA et al: Biopsy of amorphous breast calcifications: pathologic outcome and yield at stereotactic biopsy. Radiology. 221(2):495-503, 2001
                                                                  15. Lamb PM et al: Correlation between ultrasound characteristics, mammographic findings and histological grade in patients with invasive ductal carcinoma of the breast. Clin Radiol. 55(1):40-4, 2000
                                                                  16. Leung JW et al: Multiple bilateral masses detected on screening mammography: assessment of need for recall imaging. AJR Am J Roentgenol. 175(1):23-9, 2000