link
Bookmarks
Multiple Bilateral Similar Findings
Wendie A. Berg, MD, PhD, FACR, FSBI
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
14
4
0

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Definitions

              • At least 3 total findings with at least 1 in each breast
                • BI-RADS 2 assessment validated for multiple bilateral, mostly (≥ 75%) circumscribed, partially obscured masses on mammography
                  • Suggests benign etiology: Cysts ± fibroadenomas
                  • Excludes palpable findings
                  • Not applicable when there is dominant mass or suspicious finding(s)
                • Preliminary prospective validation also on screening US for solid, circumscribed, oval masses with no suspicious features
              • Multiplicity and bilaterality favor benign etiology
                • May be relevant to other findings and modalities; requires further validation

            IMAGING

            • General Features

              • Mammographic Findings

                • Ultrasonographic Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        CLINICAL ISSUES

                        • Presentation

                          • Demographics

                            • Treatment

                              DIAGNOSTIC CHECKLIST

                              • Image Interpretation Pearls

                                • Reporting Tips

                                  Selected References

                                  1. Oligane HC et al: Grouped amorphous calcifications at mammography: frequently atypical but rarely associated with aggressive malignancy. Radiology. 288(3):671-9, 2018
                                  2. Kamal RM et al: Can we apply the MRI BI-RADS lexicon morphology descriptors on contrast-enhanced spectral mammography? Br J Radiol. 20160157, 2016
                                  3. Kaur N et al: Bilateral florid juvenile fibroadenomas of the breast in an adolescent: a rare indication for subcutaneous mastectomy. J Pediatr Adolesc Gynecol. 28(5):e135-7, 2015
                                  4. Song SE et al: Undiagnosed breast cancer: features at supplemental screening US. Radiology. 277(2):372-80, 2015
                                  5. Park VY et al: Additional malignant breast lesions detected on second-look US after breast MRI vs. additional malignant lesions detected on initial US in breast cancer patients: comparison of US characteristics. Ultraschall Med. 35(5):432-9, 2014
                                  6. Berg WA et al: Multiple bilateral circumscribed masses at screening breast US: consider annual follow-up. Radiology. 268(3):673-83, 2013
                                  7. Berg WA: Screening breast ultrasound in high-risk women: ACRIN 6666 protocol. www.acrin.org/current protocols/6666. Accessed June 26, 2013
                                  8. Berg WA et al: Cystic breast masses and the ACRIN 6666 experience. Radiol Clin North Am. 48(5):931-87, 2010
                                  9. Burnside ES et al: Use of microcalcification descriptors in BI-RADS 4th edition to stratify risk of malignancy. Radiology. 242(2):388-95, 2007
                                  10. Berg WA et al: Operator dependence of physician-performed whole-breast US: lesion detection and characterization. Radiology. 241(2):355-65, 2006
                                  11. Berg WA: Breast US: Benign and probably benign lesions. In SA Feig: 2005 Syllabus, Categorical Course in Diagnostic Radiology: Breast Imaging. Oak Brook: Radiologic Society of North America.115-24, 2005
                                  12. Graf O et al: Follow-up of palpable circumscribed noncalcified solid breast masses at mammography and US: can biopsy be averted? Radiology. 233(3):850-6, 2004
                                  13. Gordon PB et al: Solid breast masses diagnosed as fibroadenoma at fine-needle aspiration biopsy: acceptable rates of growth at long-term follow-up. Radiology. 229(1):233-8, 2003
                                  14. Berg WA et al: Biopsy of amorphous breast calcifications: pathologic outcome and yield at stereotactic biopsy. Radiology. 221(2):495-503, 2001
                                  15. Lamb PM et al: Correlation between ultrasound characteristics, mammographic findings and histological grade in patients with invasive ductal carcinoma of the breast. Clin Radiol. 55(1):40-4, 2000
                                  16. Leung JW et al: Multiple bilateral masses detected on screening mammography: assessment of need for recall imaging. AJR Am J Roentgenol. 175(1):23-9, 2000
                                  Related Anatomy
                                  Loading...
                                  Related Differential Diagnoses
                                  Loading...
                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Clinical Issues

                                          • Diagnostic Checklist

                                            TERMINOLOGY

                                            • Definitions

                                              • At least 3 total findings with at least 1 in each breast
                                                • BI-RADS 2 assessment validated for multiple bilateral, mostly (≥ 75%) circumscribed, partially obscured masses on mammography
                                                  • Suggests benign etiology: Cysts ± fibroadenomas
                                                  • Excludes palpable findings
                                                  • Not applicable when there is dominant mass or suspicious finding(s)
                                                • Preliminary prospective validation also on screening US for solid, circumscribed, oval masses with no suspicious features
                                              • Multiplicity and bilaterality favor benign etiology
                                                • May be relevant to other findings and modalities; requires further validation

                                            IMAGING

                                            • General Features

                                              • Mammographic Findings

                                                • Ultrasonographic Findings

                                                  • MR Findings

                                                    • Imaging Recommendations

                                                      DIFFERENTIAL DIAGNOSIS

                                                        CLINICAL ISSUES

                                                        • Presentation

                                                          • Demographics

                                                            • Treatment

                                                              DIAGNOSTIC CHECKLIST

                                                              • Image Interpretation Pearls

                                                                • Reporting Tips

                                                                  Selected References

                                                                  1. Oligane HC et al: Grouped amorphous calcifications at mammography: frequently atypical but rarely associated with aggressive malignancy. Radiology. 288(3):671-9, 2018
                                                                  2. Kamal RM et al: Can we apply the MRI BI-RADS lexicon morphology descriptors on contrast-enhanced spectral mammography? Br J Radiol. 20160157, 2016
                                                                  3. Kaur N et al: Bilateral florid juvenile fibroadenomas of the breast in an adolescent: a rare indication for subcutaneous mastectomy. J Pediatr Adolesc Gynecol. 28(5):e135-7, 2015
                                                                  4. Song SE et al: Undiagnosed breast cancer: features at supplemental screening US. Radiology. 277(2):372-80, 2015
                                                                  5. Park VY et al: Additional malignant breast lesions detected on second-look US after breast MRI vs. additional malignant lesions detected on initial US in breast cancer patients: comparison of US characteristics. Ultraschall Med. 35(5):432-9, 2014
                                                                  6. Berg WA et al: Multiple bilateral circumscribed masses at screening breast US: consider annual follow-up. Radiology. 268(3):673-83, 2013
                                                                  7. Berg WA: Screening breast ultrasound in high-risk women: ACRIN 6666 protocol. www.acrin.org/current protocols/6666. Accessed June 26, 2013
                                                                  8. Berg WA et al: Cystic breast masses and the ACRIN 6666 experience. Radiol Clin North Am. 48(5):931-87, 2010
                                                                  9. Burnside ES et al: Use of microcalcification descriptors in BI-RADS 4th edition to stratify risk of malignancy. Radiology. 242(2):388-95, 2007
                                                                  10. Berg WA et al: Operator dependence of physician-performed whole-breast US: lesion detection and characterization. Radiology. 241(2):355-65, 2006
                                                                  11. Berg WA: Breast US: Benign and probably benign lesions. In SA Feig: 2005 Syllabus, Categorical Course in Diagnostic Radiology: Breast Imaging. Oak Brook: Radiologic Society of North America.115-24, 2005
                                                                  12. Graf O et al: Follow-up of palpable circumscribed noncalcified solid breast masses at mammography and US: can biopsy be averted? Radiology. 233(3):850-6, 2004
                                                                  13. Gordon PB et al: Solid breast masses diagnosed as fibroadenoma at fine-needle aspiration biopsy: acceptable rates of growth at long-term follow-up. Radiology. 229(1):233-8, 2003
                                                                  14. Berg WA et al: Biopsy of amorphous breast calcifications: pathologic outcome and yield at stereotactic biopsy. Radiology. 221(2):495-503, 2001
                                                                  15. Lamb PM et al: Correlation between ultrasound characteristics, mammographic findings and histological grade in patients with invasive ductal carcinoma of the breast. Clin Radiol. 55(1):40-4, 2000
                                                                  16. Leung JW et al: Multiple bilateral masses detected on screening mammography: assessment of need for recall imaging. AJR Am J Roentgenol. 175(1):23-9, 2000