link
Bookmarks
Multiple Myeloma
Chris Hanrahan, MD, PhD
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
1
20
19
0

KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Abbreviations

            • Multiple myeloma (MM)
            • Monoclonal gammopathy (MG)
            • MG of undetermined significance (MGUS)
            • MG of borderline significance (MGBS)
            • Smoldering multiple myeloma (SMM)
            • Solitary bone plasmacytoma (SBP)
          • Synonyms

            • Symptomatic multiple myeloma
          • Definitions

            • Most common primary malignancy of bone
            • Plasma cell disorder → primarily in bone marrow (BM)

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • PET/CT Findings

                    • Response to Therapy

                      • Imaging Recommendations

                        • Nuclear Medicine Findings

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Reporting Tips

                                            Selected References

                                            1. Giles SL et al: Whole-body diffusion-weighted MR imaging for assessment of treatment response in myeloma. Radiology. 271(3):785-94, 2014
                                            2. Padhani AR et al: Assessing the relation between bone marrow signal intensity and apparent diffusion coefficient in diffusion-weighted MRI. AJR Am J Roentgenol. 200(1):163-70, 2013
                                            3. Hanrahan CJ et al: Current concepts in the evaluation of multiple myeloma with MR imaging and FDG PET/CT. Radiographics. 30(1):127-42, 2010
                                            4. Lin C et al: Multiple myeloma treatment response assessment with whole-body dynamic contrast-enhanced MR imaging. Radiology. 254(2):521-31, 2010
                                            5. Dimopoulos M et al: International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple myeloma. Leukemia. 23(9):1545-56, 2009
                                            6. Shortt CP et al: Whole-Body MRI versus PET in assessment of multiple myeloma disease activity. AJR Am J Roentgenol. 192(4):980-6, 2009
                                            7. Baur-Melnyk A et al: Whole-body MRI versus whole-body MDCT for staging of multiple myeloma. AJR Am J Roentgenol. 190(4):1097-104, 2008
                                            8. Kyle RA et al: Multiple myeloma. Blood. 111(6):2962-72, 2008
                                            9. D'Sa S et al: Guidelines for the use of imaging in the management of myeloma. Br J Haematol. 137(1):49-63, 2007
                                            10. Durie BG: The role of anatomic and functional staging in myeloma: description of Durie/Salmon plus staging system. Eur J Cancer. 42(11):1539-43, 2006
                                            11. Greipp PR et al: International staging system for multiple myeloma. J Clin Oncol. 2005 May 20;23(15):3412-20. Epub 2005 Apr 4. Erratum in: J Clin Oncol. 23(25):6281, 2005
                                            12. Angtuaco EJ et al: Multiple myeloma: clinical review and diagnostic imaging. Radiology. 231(1):11-23, 2004
                                            13. International Myeloma Working Group: Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol. 121(5):749-57, 2003
                                            14. Baur A et al: Magnetic resonance imaging as a supplement for the clinical staging system of Durie and Salmon? Cancer. 95(6):1334-45, 2002
                                            15. Rahmouni A et al: MR appearance of multiple myeloma of the spine before and after treatment. AJR Am J Roentgenol. 160(5):1053-7, 1993
                                            16. Durie BG et al: A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer. 36(3):842-54, 1975
                                            Related Anatomy
                                            Loading...
                                            Related Differential Diagnoses
                                            Loading...
                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Multiple myeloma (MM)
                                                      • Monoclonal gammopathy (MG)
                                                      • MG of undetermined significance (MGUS)
                                                      • MG of borderline significance (MGBS)
                                                      • Smoldering multiple myeloma (SMM)
                                                      • Solitary bone plasmacytoma (SBP)
                                                    • Synonyms

                                                      • Symptomatic multiple myeloma
                                                    • Definitions

                                                      • Most common primary malignancy of bone
                                                      • Plasma cell disorder → primarily in bone marrow (BM)

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • PET/CT Findings

                                                              • Response to Therapy

                                                                • Imaging Recommendations

                                                                  • Nuclear Medicine Findings

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Reporting Tips

                                                                                      Selected References

                                                                                      1. Giles SL et al: Whole-body diffusion-weighted MR imaging for assessment of treatment response in myeloma. Radiology. 271(3):785-94, 2014
                                                                                      2. Padhani AR et al: Assessing the relation between bone marrow signal intensity and apparent diffusion coefficient in diffusion-weighted MRI. AJR Am J Roentgenol. 200(1):163-70, 2013
                                                                                      3. Hanrahan CJ et al: Current concepts in the evaluation of multiple myeloma with MR imaging and FDG PET/CT. Radiographics. 30(1):127-42, 2010
                                                                                      4. Lin C et al: Multiple myeloma treatment response assessment with whole-body dynamic contrast-enhanced MR imaging. Radiology. 254(2):521-31, 2010
                                                                                      5. Dimopoulos M et al: International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple myeloma. Leukemia. 23(9):1545-56, 2009
                                                                                      6. Shortt CP et al: Whole-Body MRI versus PET in assessment of multiple myeloma disease activity. AJR Am J Roentgenol. 192(4):980-6, 2009
                                                                                      7. Baur-Melnyk A et al: Whole-body MRI versus whole-body MDCT for staging of multiple myeloma. AJR Am J Roentgenol. 190(4):1097-104, 2008
                                                                                      8. Kyle RA et al: Multiple myeloma. Blood. 111(6):2962-72, 2008
                                                                                      9. D'Sa S et al: Guidelines for the use of imaging in the management of myeloma. Br J Haematol. 137(1):49-63, 2007
                                                                                      10. Durie BG: The role of anatomic and functional staging in myeloma: description of Durie/Salmon plus staging system. Eur J Cancer. 42(11):1539-43, 2006
                                                                                      11. Greipp PR et al: International staging system for multiple myeloma. J Clin Oncol. 2005 May 20;23(15):3412-20. Epub 2005 Apr 4. Erratum in: J Clin Oncol. 23(25):6281, 2005
                                                                                      12. Angtuaco EJ et al: Multiple myeloma: clinical review and diagnostic imaging. Radiology. 231(1):11-23, 2004
                                                                                      13. International Myeloma Working Group: Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol. 121(5):749-57, 2003
                                                                                      14. Baur A et al: Magnetic resonance imaging as a supplement for the clinical staging system of Durie and Salmon? Cancer. 95(6):1334-45, 2002
                                                                                      15. Rahmouni A et al: MR appearance of multiple myeloma of the spine before and after treatment. AJR Am J Roentgenol. 160(5):1053-7, 1993
                                                                                      16. Durie BG et al: A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer. 36(3):842-54, 1975