Inherited muscle diseases with progressive weakness and wasting of skeletal muscles of varying distribution and severity
Genetic mutation of proteins involved in induction of muscular contractile force &/or prevents muscular relaxation
Heart is involved in several muscular dystrophies
May be predominant manifestation
Due to shared proteins of cardiac and skeletal muscles
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Molecular Basis
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Magrath P et al: Cardiac MRI biomarkers for Duchenne muscular dystrophy. Biomark Med. ePub, 2018
Marty B et al: Comprehensive evaluation of structural and functional myocardial impairments in Becker muscular dystrophy using quantitative cardiac magnetic resonance imaging. Eur Heart J Cardiovasc Imaging. ePub, 2018
Power LC et al: Imaging the heart to detect cardiomyopathy in Duchenne muscular dystrophy: A review. Neuromuscul Disord. 28(9):717-730, 2018
Siegel B et al: Myocardial Strain Using Cardiac MR Feature Tracking and Speckle Tracking Echocardiography in Duchenne Muscular Dystrophy Patients. Pediatr Cardiol. 39(3):478-483, 2018
Kalisz K et al: Computed tomography of cardiomyopathies. Cardiovasc Diagn Ther. 7(5):539-556, 2017
Roller FC et al: Value of Cardiac T1-Mapping and ECV Quantification in Duchenne Muscular Dystrophy (DMD): Case Report, Typical Imaging Findings and Review of the Literature. Rofo. 189(1):75-77, 2017
Choudhary P et al: Structural and electrical cardiac abnormalities are prevalent in asymptomatic adults with myotonic dystrophy. Heart. 102(18):1472-8, 2016
Olivieri LJ et al: Native T1 values identify myocardial changes and stratify disease severity in patients with Duchenne muscular dystrophy. J Cardiovasc Magn Reson. 18(1):72, 2016
Brunklaus A et al: The value of cardiac MRI versus echocardiography in the pre-operative assessment of patients with Duchenne muscular dystrophy. Eur J Paediatr Neurol. 19(4):395-401, 2015
Soslow JH et al: Evaluation of post-contrast myocardial t1 in duchenne muscular dystrophy using cardiac magnetic resonance imaging. Pediatr Cardiol. 36(1):49-56, 2015
Tandon A et al: Dystrophin genotype-cardiac phenotype correlations in Duchenne and Becker muscular dystrophies using cardiac magnetic resonance imaging. Am J Cardiol. 115(7):967-71, 2015
Tandon A et al: Myocardial fibrosis burden predicts left ventricular ejection fraction and is associated with age and steroid treatment duration in duchenne muscular dystrophy. J Am Heart Assoc. 4(4), 2015
Florian A et al: Left ventricular systolic function and the pattern of late-gadolinium-enhancement independently and additively predict adverse cardiac events in muscular dystrophy patients. J Cardiovasc Magn Reson. 16(1):81, 2014
Otto RK et al: Cardiac MRI in muscular dystrophy: an overview and future directions. Phys Med Rehabil Clin N Am. 23(1):123-32, xi-xii, 2012
Verhaert D et al: Cardiac involvement in patients with muscular dystrophies: magnetic resonance imaging phenotype and genotypic considerations. Circ Cardiovasc Imaging. 4(1):67-76, 2011
Taylor AJ et al: ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 Appropriate Use Criteria for Cardiac Computed Tomography. A Report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the North American Society for Cardiovascular Imaging, the Society for Cardiovascular Angiography and Interventions, and the Society for Cardiovascular Magnetic Resonance. J Cardiovasc Comput Tomogr. 4(6):407.e1-33, 2010
Emery AE: Muscular dystrophy into the new millennium. Neuromuscul Disord. 12(4):343-9, 2002
Buckley AE et al: Cardiac involvement in Emery Dreifuss muscular dystrophy: a case series. Heart. 82(1):105-8, 1999
T1 mapping in Becker muscular dystrophy patients detects diffuse microfibrosis prior to evidence of late gadolinium enhancement or cardiac dysfunction
Inherited muscle diseases with progressive weakness and wasting of skeletal muscles of varying distribution and severity
Genetic mutation of proteins involved in induction of muscular contractile force &/or prevents muscular relaxation
Heart is involved in several muscular dystrophies
May be predominant manifestation
Due to shared proteins of cardiac and skeletal muscles
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Molecular Basis
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Magrath P et al: Cardiac MRI biomarkers for Duchenne muscular dystrophy. Biomark Med. ePub, 2018
Marty B et al: Comprehensive evaluation of structural and functional myocardial impairments in Becker muscular dystrophy using quantitative cardiac magnetic resonance imaging. Eur Heart J Cardiovasc Imaging. ePub, 2018
Power LC et al: Imaging the heart to detect cardiomyopathy in Duchenne muscular dystrophy: A review. Neuromuscul Disord. 28(9):717-730, 2018
Siegel B et al: Myocardial Strain Using Cardiac MR Feature Tracking and Speckle Tracking Echocardiography in Duchenne Muscular Dystrophy Patients. Pediatr Cardiol. 39(3):478-483, 2018
Kalisz K et al: Computed tomography of cardiomyopathies. Cardiovasc Diagn Ther. 7(5):539-556, 2017
Roller FC et al: Value of Cardiac T1-Mapping and ECV Quantification in Duchenne Muscular Dystrophy (DMD): Case Report, Typical Imaging Findings and Review of the Literature. Rofo. 189(1):75-77, 2017
Choudhary P et al: Structural and electrical cardiac abnormalities are prevalent in asymptomatic adults with myotonic dystrophy. Heart. 102(18):1472-8, 2016
Olivieri LJ et al: Native T1 values identify myocardial changes and stratify disease severity in patients with Duchenne muscular dystrophy. J Cardiovasc Magn Reson. 18(1):72, 2016
Brunklaus A et al: The value of cardiac MRI versus echocardiography in the pre-operative assessment of patients with Duchenne muscular dystrophy. Eur J Paediatr Neurol. 19(4):395-401, 2015
Soslow JH et al: Evaluation of post-contrast myocardial t1 in duchenne muscular dystrophy using cardiac magnetic resonance imaging. Pediatr Cardiol. 36(1):49-56, 2015
Tandon A et al: Dystrophin genotype-cardiac phenotype correlations in Duchenne and Becker muscular dystrophies using cardiac magnetic resonance imaging. Am J Cardiol. 115(7):967-71, 2015
Tandon A et al: Myocardial fibrosis burden predicts left ventricular ejection fraction and is associated with age and steroid treatment duration in duchenne muscular dystrophy. J Am Heart Assoc. 4(4), 2015
Florian A et al: Left ventricular systolic function and the pattern of late-gadolinium-enhancement independently and additively predict adverse cardiac events in muscular dystrophy patients. J Cardiovasc Magn Reson. 16(1):81, 2014
Otto RK et al: Cardiac MRI in muscular dystrophy: an overview and future directions. Phys Med Rehabil Clin N Am. 23(1):123-32, xi-xii, 2012
Verhaert D et al: Cardiac involvement in patients with muscular dystrophies: magnetic resonance imaging phenotype and genotypic considerations. Circ Cardiovasc Imaging. 4(1):67-76, 2011
Taylor AJ et al: ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 Appropriate Use Criteria for Cardiac Computed Tomography. A Report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the North American Society for Cardiovascular Imaging, the Society for Cardiovascular Angiography and Interventions, and the Society for Cardiovascular Magnetic Resonance. J Cardiovasc Comput Tomogr. 4(6):407.e1-33, 2010
Emery AE: Muscular dystrophy into the new millennium. Neuromuscul Disord. 12(4):343-9, 2002
Buckley AE et al: Cardiac involvement in Emery Dreifuss muscular dystrophy: a case series. Heart. 82(1):105-8, 1999
T1 mapping in Becker muscular dystrophy patients detects diffuse microfibrosis prior to evidence of late gadolinium enhancement or cardiac dysfunction
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