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Myelofibrosis
Kevin R. Moore, MD; Jeffrey S. Ross, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Myelosclerosis; agnogenic myeloid metaplasia
              • Definitions

                • Myelodysplastic syndrome characterized by marrow replacement with fibrous tissue

              IMAGING

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Nakamura G et al: Magnetic resonance imaging of bone marrow for TAFRO syndrome. Mod Rheumatol. 29(3):551-7, 2019
                                      2. Caranci F et al: Magnetic resonance imaging correlates of benign and malignant alterations of the spinal bone marrow. Acta Biomed. 89(1-S):18-33, 2018
                                      3. Verstovsek S et al: Efficacy, safety and survival with ruxolitinib in patients with myelofibrosis: results of a median 2-year follow-up of COMFORT-I. Haematologica. 98(12):1865-71, 2013
                                      4. Etienne A et al: Myelofibrosis-associated lymphoproliferative disease: retrospective study of 16 cases and literature review. Adv Hematol. 2009:179847, 2009
                                      5. Orazi A et al: Myelodysplastic syndromes. Am J Clin Pathol. 132(2):290-305, 2009
                                      6. Barosi G: Myelofibrosis with myeloid metaplasia. Hematol Oncol Clin North Am. 17(5):1211-26, 2003
                                      7. Diamond T et al: Syndrome of myelofibrosis and osteosclerosis: a series of case reports and review of the literature. Bone. 30(3):498-501, 2002
                                      8. Mesa RA: The therapy of myelofibrosis: targeting pathogenesis. Int J Hematol. 76 Suppl 2:296-304, 2002
                                      9. Bass RD et al: Pathology of autoimmune myelofibrosis. A report of three cases and a review of the literature. Am J Clin Pathol. 116(2):211-6, 2001
                                      10. Smith BD et al: Biology and management of idiopathic myelofibrosis. Curr Opin Oncol. 13(2):91-4, 2001
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Synonyms

                                                    • Myelosclerosis; agnogenic myeloid metaplasia
                                                  • Definitions

                                                    • Myelodysplastic syndrome characterized by marrow replacement with fibrous tissue

                                                  IMAGING

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Nakamura G et al: Magnetic resonance imaging of bone marrow for TAFRO syndrome. Mod Rheumatol. 29(3):551-7, 2019
                                                                          2. Caranci F et al: Magnetic resonance imaging correlates of benign and malignant alterations of the spinal bone marrow. Acta Biomed. 89(1-S):18-33, 2018
                                                                          3. Verstovsek S et al: Efficacy, safety and survival with ruxolitinib in patients with myelofibrosis: results of a median 2-year follow-up of COMFORT-I. Haematologica. 98(12):1865-71, 2013
                                                                          4. Etienne A et al: Myelofibrosis-associated lymphoproliferative disease: retrospective study of 16 cases and literature review. Adv Hematol. 2009:179847, 2009
                                                                          5. Orazi A et al: Myelodysplastic syndromes. Am J Clin Pathol. 132(2):290-305, 2009
                                                                          6. Barosi G: Myelofibrosis with myeloid metaplasia. Hematol Oncol Clin North Am. 17(5):1211-26, 2003
                                                                          7. Diamond T et al: Syndrome of myelofibrosis and osteosclerosis: a series of case reports and review of the literature. Bone. 30(3):498-501, 2002
                                                                          8. Mesa RA: The therapy of myelofibrosis: targeting pathogenesis. Int J Hematol. 76 Suppl 2:296-304, 2002
                                                                          9. Bass RD et al: Pathology of autoimmune myelofibrosis. A report of three cases and a review of the literature. Am J Clin Pathol. 116(2):211-6, 2001
                                                                          10. Smith BD et al: Biology and management of idiopathic myelofibrosis. Curr Opin Oncol. 13(2):91-4, 2001