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Myelofibrosis
Julia R. Crim, MD; Jeffrey S. Ross, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Myelosclerosis
              • Agnogenic myeloid metaplasia
            • Definitions

              • Myelodysplastic syndrome characterized by marrow replacement with fibrous tissue

            IMAGING

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Image Interpretation Pearls

                                    Selected References

                                    1. Verstovsek S et al: Efficacy, safety and survival with ruxolitinib in patients with myelofibrosis: results of a median 2-year follow-up of COMFORT-I. Haematologica. 98(12):1865-71, 2013
                                    2. Etienne A et al: Myelofibrosis-associated lymphoproliferative disease: retrospective study of 16 cases and literature review. Adv Hematol. 2009:179847, 2009
                                    3. Orazi A et al: Myelodysplastic syndromes. Am J Clin Pathol. 132(2):290-305, 2009
                                    4. Barosi G: Myelofibrosis with myeloid metaplasia. Hematol Oncol Clin North Am. 17(5):1211-26, 2003
                                    5. Diamond T et al: Syndrome of myelofibrosis and osteosclerosis: a series of case reports and review of the literature. Bone. 30(3):498-501, 2002
                                    6. Mesa RA: The therapy of myelofibrosis: targeting pathogenesis. Int J Hematol. 76 Suppl 2:296-304, 2002
                                    7. Bass RD et al: Pathology of autoimmune myelofibrosis. A report of three cases and a review of the literature. Am J Clin Pathol. 116(2):211-6, 2001
                                    8. Smith BD et al: Biology and management of idiopathic myelofibrosis. Curr Opin Oncol. 13(2):91-4, 2001
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Pathology

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Synonyms

                                                • Myelosclerosis
                                                • Agnogenic myeloid metaplasia
                                              • Definitions

                                                • Myelodysplastic syndrome characterized by marrow replacement with fibrous tissue

                                              IMAGING

                                              • Radiographic Findings

                                                • CT Findings

                                                  • MR Findings

                                                    • Imaging Recommendations

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Microscopic Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Image Interpretation Pearls

                                                                      Selected References

                                                                      1. Verstovsek S et al: Efficacy, safety and survival with ruxolitinib in patients with myelofibrosis: results of a median 2-year follow-up of COMFORT-I. Haematologica. 98(12):1865-71, 2013
                                                                      2. Etienne A et al: Myelofibrosis-associated lymphoproliferative disease: retrospective study of 16 cases and literature review. Adv Hematol. 2009:179847, 2009
                                                                      3. Orazi A et al: Myelodysplastic syndromes. Am J Clin Pathol. 132(2):290-305, 2009
                                                                      4. Barosi G: Myelofibrosis with myeloid metaplasia. Hematol Oncol Clin North Am. 17(5):1211-26, 2003
                                                                      5. Diamond T et al: Syndrome of myelofibrosis and osteosclerosis: a series of case reports and review of the literature. Bone. 30(3):498-501, 2002
                                                                      6. Mesa RA: The therapy of myelofibrosis: targeting pathogenesis. Int J Hematol. 76 Suppl 2:296-304, 2002
                                                                      7. Bass RD et al: Pathology of autoimmune myelofibrosis. A report of three cases and a review of the literature. Am J Clin Pathol. 116(2):211-6, 2001
                                                                      8. Smith BD et al: Biology and management of idiopathic myelofibrosis. Curr Opin Oncol. 13(2):91-4, 2001