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Myeloma
Anne G. Osborn, MD, FACR; Miral D. Jhaveri, MD, MBA
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Solitary = plasmacytoma (PC)
              • Solitary PC of bone
              • Extramedullary PC (includes brain/CNS)
            • Multifocal = multiple myeloma (MM)
          • Definitions

            • Clonal B-lymphocyte neoplasm of terminally differentiated plasma cells

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Other Modality Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Oka S et al: Successful treatment with pomalidomide and intrathecal injections for central nervous system plasmacytoma in a patient under haemodialysis. J Clin Pharm Ther. 45(1):221-5, 2020
                                            2. Elhassadi E et al: Durable treatment response of relapsing CNS plasmacytoma using intrathecal chemotherapy, radiotherapy, and Daratumumab. Clin Case Rep. 6(4):723-8, 2018
                                            3. Shpilberg KA et al: Imaging of extraosseous intracranial and intraspinal multiple myeloma, including central nervous system involvement. Clin Imaging. 39(2):213-9, 2015
                                            4. Abdallah AO et al: Patterns of central nervous system involvement in relapsed and refractory multiple myeloma. Clin Lymphoma Myeloma Leuk. 14(3):211-4, 2014
                                            5. Wu W et al: Extraosseous plasmacytoma with an aggressive course occurring solely in the CNS. Neuropathology. 33(3):320-3, 2013
                                            6. Baur-Melnyk A et al: Multiple myeloma. Semin Musculoskelet Radiol. 13(2):111-9, 2009
                                            7. Delorme S et al: Imaging in multiple myeloma. Eur J Radiol. 70(3):401-8, 2009
                                            8. Cerase A et al: Intracranial involvement in plasmacytomas and multiple myeloma: a pictorial essay. Neuroradiology. 50(8):665-74, 2008
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Solitary = plasmacytoma (PC)
                                                        • Solitary PC of bone
                                                        • Extramedullary PC (includes brain/CNS)
                                                      • Multifocal = multiple myeloma (MM)
                                                    • Definitions

                                                      • Clonal B-lymphocyte neoplasm of terminally differentiated plasma cells

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              • Other Modality Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Staging, Grading, & Classification

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Oka S et al: Successful treatment with pomalidomide and intrathecal injections for central nervous system plasmacytoma in a patient under haemodialysis. J Clin Pharm Ther. 45(1):221-5, 2020
                                                                                      2. Elhassadi E et al: Durable treatment response of relapsing CNS plasmacytoma using intrathecal chemotherapy, radiotherapy, and Daratumumab. Clin Case Rep. 6(4):723-8, 2018
                                                                                      3. Shpilberg KA et al: Imaging of extraosseous intracranial and intraspinal multiple myeloma, including central nervous system involvement. Clin Imaging. 39(2):213-9, 2015
                                                                                      4. Abdallah AO et al: Patterns of central nervous system involvement in relapsed and refractory multiple myeloma. Clin Lymphoma Myeloma Leuk. 14(3):211-4, 2014
                                                                                      5. Wu W et al: Extraosseous plasmacytoma with an aggressive course occurring solely in the CNS. Neuropathology. 33(3):320-3, 2013
                                                                                      6. Baur-Melnyk A et al: Multiple myeloma. Semin Musculoskelet Radiol. 13(2):111-9, 2009
                                                                                      7. Delorme S et al: Imaging in multiple myeloma. Eur J Radiol. 70(3):401-8, 2009
                                                                                      8. Cerase A et al: Intracranial involvement in plasmacytomas and multiple myeloma: a pictorial essay. Neuroradiology. 50(8):665-74, 2008