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Myeloma
Anne G. Osborn, MD, FACR; Miral D. Jhaveri, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Solitary = plasmacytoma (PC)
              • Solitary plasmacytoma of bone
              • Extramedullary plasmacytoma (includes brain/CNS)
            • Multifocal = multiple myeloma (MM)
          • Definitions

            • Clonal B-lymphocyte neoplasm of terminally differentiated plasma cells

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Angiographic Findings

                    • Nuclear Medicine Findings

                      • Other Modality Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Ghodke K et al: A retrospective study of correlation of morphologic patterns, MIB1 proliferation index, and survival analysis in 134 cases of plasmacytoma. Ann Diagn Pathol. ePub, 2015
                                              2. Shpilberg KA et al: Imaging of extraosseous intracranial and intraspinal multiple myeloma, including central nervous system involvement. Clin Imaging. 39(2):213-9, 2015
                                              3. Abdallah AO et al: Patterns of central nervous system involvement in relapsed and refractory multiple myeloma. Clin Lymphoma Myeloma Leuk. 14(3):211-4, 2014
                                              4. Marini A et al: Myelomatous meningitis evaluated by multiparameter flow cytometry : report of a case and review of the literature. J Clin Exp Hematop. 54(2):129-36, 2014
                                              5. Baur-Melnyk A et al: Multiple myeloma. Semin Musculoskelet Radiol. 13(2):111-9, 2009
                                              6. Delorme S et al: Imaging in multiple myeloma. Eur J Radiol. 70(3):401-8, 2009
                                              7. Dimopoulos M et al: International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple Myeloma. Leukemia. 23(9):1545-56, 2009
                                              8. Winterbottom AP et al: Imaging patients with myeloma. Clin Radiol. 64(1):1-11, 2009
                                              9. Cerase A et al: Intracranial involvement in plasmacytomas and multiple myeloma: a pictorial essay. Neuroradiology. 50(8):665-74, 2008
                                              10. Seppanen M: Modern imaging of multiple myeloma. Acta Radiol. 49(5):487-8, 2008
                                              11. Angtuaco EJ et al: Multiple myeloma: clinical review and diagnostic imaging. Radiology. 231(1):11-23, 2004
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Solitary = plasmacytoma (PC)
                                                          • Solitary plasmacytoma of bone
                                                          • Extramedullary plasmacytoma (includes brain/CNS)
                                                        • Multifocal = multiple myeloma (MM)
                                                      • Definitions

                                                        • Clonal B-lymphocyte neoplasm of terminally differentiated plasma cells

                                                      IMAGING

                                                      • General Features

                                                        • Radiographic Findings

                                                          • CT Findings

                                                            • MR Findings

                                                              • Angiographic Findings

                                                                • Nuclear Medicine Findings

                                                                  • Other Modality Findings

                                                                    • Imaging Recommendations

                                                                      DIFFERENTIAL DIAGNOSIS

                                                                        PATHOLOGY

                                                                        • General Features

                                                                          • Staging, Grading, & Classification

                                                                            • Gross Pathologic & Surgical Features

                                                                              • Microscopic Features

                                                                                CLINICAL ISSUES

                                                                                • Presentation

                                                                                  • Demographics

                                                                                    • Natural History & Prognosis

                                                                                      • Treatment

                                                                                        DIAGNOSTIC CHECKLIST

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Ghodke K et al: A retrospective study of correlation of morphologic patterns, MIB1 proliferation index, and survival analysis in 134 cases of plasmacytoma. Ann Diagn Pathol. ePub, 2015
                                                                                          2. Shpilberg KA et al: Imaging of extraosseous intracranial and intraspinal multiple myeloma, including central nervous system involvement. Clin Imaging. 39(2):213-9, 2015
                                                                                          3. Abdallah AO et al: Patterns of central nervous system involvement in relapsed and refractory multiple myeloma. Clin Lymphoma Myeloma Leuk. 14(3):211-4, 2014
                                                                                          4. Marini A et al: Myelomatous meningitis evaluated by multiparameter flow cytometry : report of a case and review of the literature. J Clin Exp Hematop. 54(2):129-36, 2014
                                                                                          5. Baur-Melnyk A et al: Multiple myeloma. Semin Musculoskelet Radiol. 13(2):111-9, 2009
                                                                                          6. Delorme S et al: Imaging in multiple myeloma. Eur J Radiol. 70(3):401-8, 2009
                                                                                          7. Dimopoulos M et al: International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple Myeloma. Leukemia. 23(9):1545-56, 2009
                                                                                          8. Winterbottom AP et al: Imaging patients with myeloma. Clin Radiol. 64(1):1-11, 2009
                                                                                          9. Cerase A et al: Intracranial involvement in plasmacytomas and multiple myeloma: a pictorial essay. Neuroradiology. 50(8):665-74, 2008
                                                                                          10. Seppanen M: Modern imaging of multiple myeloma. Acta Radiol. 49(5):487-8, 2008
                                                                                          11. Angtuaco EJ et al: Multiple myeloma: clinical review and diagnostic imaging. Radiology. 231(1):11-23, 2004