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Myoepithelial Neoplasms
Nicole S. Winkler, MD; Wendie A. Berg, MD, PhD, FACR, FSBI
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Myoepithelial lesion: Rare benign or malignant neoplasm arising from dominant or pure proliferation of myoepithelial cells
                • Adenomyoepithelioma (AME): Most common, also contains glandular (epithelial) elements

            IMAGING

            • General Features

              • Mammographic Findings

                • Ultrasonographic Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      Selected References

                                      1. Torous VF et al: Benign breast lesions that mimic malignancy. Pathology. 49(2):181-196, 2017
                                      2. Moritz AW et al: Breast adenomyoepithelioma and adenomyoepithelioma with carcinoma (malignant adenomyoepithelioma) with associated breast malignancies: A case series emphasizing histologic, radiologic, and clinical correlation. Breast. 29:132-9, 2016
                                      3. Zhang L et al: The mammography and MRI manifestations of adenomyoepithelioma of the breast. Clin Radiol. 71(3):235-43, 2016
                                      4. Leekha N et al: Pleomorphic adenoma of breast-a case report and review of literature. Indian J Surg Oncol. 5(2):152-4, 2014
                                      5. Park YM et al: Imaging features of benign adenomyoepithelioma of the breast. J Clin Ultrasound. 41(4):218-23, 2013
                                      6. Lakhani SR, Ellis IO, Schnitt SJ, et al. WHO classification of tumours of the breast. Lyon: IARC, 2012
                                      7. Adejolu M et al: Adenomyoepithelial tumors of the breast: imaging findings with histopathologic correlation. AJR Am J Roentgenol. 197(1):W184-90, 2011
                                      8. Lee JH et al: Ultrasonographic features of benign adenomyoepithelioma of the breast. Korean J Radiol. 11(5):522-7, 2010
                                      9. Fan F et al: Myoepithelial carcinoma of the breast arising in an adenomyoepithelioma: mammographic, ultrasound and histologic features. Breast J. 13(2):203-4, 2007
                                      10. Mercado CL et al: Fine-needle aspiration biopsy of benign adenomyoepithelioma of the breast: radiologic and pathologic correlation in four cases. Diagn Cytopathol. 35(11):690-4, 2007
                                      11. Ruiz-Delgado ML et al: Benign adenomyoepithelioma of the breast: imaging findings mimicking malignancy and histopathological features. Acta Radiol. 48(1):27-9, 2007
                                      12. Nadelman CM et al: "Benign," metastasizing adenomyoepithelioma of the breast: a report of 2 cases. Arch Pathol Lab Med. 130(9):1349-53, 2006
                                      13. Howlett DC et al: Adenomyoepithelioma of the breast: spectrum of disease with associated imaging and pathology. AJR Am J Roentgenol. 180(3):799-803, 2003
                                      14. Doyle AJ et al: Myoepithelial lesions of the breast: imaging characteristics and diagnosis with large-core needle biopsy in two cases. Radiology. 193(3):787-8, 1994
                                      15. Tavassoli FA: Myoepithelial lesions of the breast. Myoepitheliosis, adenomyoepithelioma, and myoepithelial carcinoma. Am J Surg Pathol. 15(6):554-68, 1991
                                      16. Ballance WA et al: Pleomorphic adenoma (benign mixed tumor) of the breast. An immunohistochemical, flow cytometric, and ultrastructural study and review of the literature. Am J Clin Pathol. 93(6):795-801, 1990
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Definitions

                                                  • Myoepithelial lesion: Rare benign or malignant neoplasm arising from dominant or pure proliferation of myoepithelial cells
                                                    • Adenomyoepithelioma (AME): Most common, also contains glandular (epithelial) elements

                                                IMAGING

                                                • General Features

                                                  • Mammographic Findings

                                                    • Ultrasonographic Findings

                                                      • MR Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • Staging, Grading, & Classification

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          Selected References

                                                                          1. Torous VF et al: Benign breast lesions that mimic malignancy. Pathology. 49(2):181-196, 2017
                                                                          2. Moritz AW et al: Breast adenomyoepithelioma and adenomyoepithelioma with carcinoma (malignant adenomyoepithelioma) with associated breast malignancies: A case series emphasizing histologic, radiologic, and clinical correlation. Breast. 29:132-9, 2016
                                                                          3. Zhang L et al: The mammography and MRI manifestations of adenomyoepithelioma of the breast. Clin Radiol. 71(3):235-43, 2016
                                                                          4. Leekha N et al: Pleomorphic adenoma of breast-a case report and review of literature. Indian J Surg Oncol. 5(2):152-4, 2014
                                                                          5. Park YM et al: Imaging features of benign adenomyoepithelioma of the breast. J Clin Ultrasound. 41(4):218-23, 2013
                                                                          6. Lakhani SR, Ellis IO, Schnitt SJ, et al. WHO classification of tumours of the breast. Lyon: IARC, 2012
                                                                          7. Adejolu M et al: Adenomyoepithelial tumors of the breast: imaging findings with histopathologic correlation. AJR Am J Roentgenol. 197(1):W184-90, 2011
                                                                          8. Lee JH et al: Ultrasonographic features of benign adenomyoepithelioma of the breast. Korean J Radiol. 11(5):522-7, 2010
                                                                          9. Fan F et al: Myoepithelial carcinoma of the breast arising in an adenomyoepithelioma: mammographic, ultrasound and histologic features. Breast J. 13(2):203-4, 2007
                                                                          10. Mercado CL et al: Fine-needle aspiration biopsy of benign adenomyoepithelioma of the breast: radiologic and pathologic correlation in four cases. Diagn Cytopathol. 35(11):690-4, 2007
                                                                          11. Ruiz-Delgado ML et al: Benign adenomyoepithelioma of the breast: imaging findings mimicking malignancy and histopathological features. Acta Radiol. 48(1):27-9, 2007
                                                                          12. Nadelman CM et al: "Benign," metastasizing adenomyoepithelioma of the breast: a report of 2 cases. Arch Pathol Lab Med. 130(9):1349-53, 2006
                                                                          13. Howlett DC et al: Adenomyoepithelioma of the breast: spectrum of disease with associated imaging and pathology. AJR Am J Roentgenol. 180(3):799-803, 2003
                                                                          14. Doyle AJ et al: Myoepithelial lesions of the breast: imaging characteristics and diagnosis with large-core needle biopsy in two cases. Radiology. 193(3):787-8, 1994
                                                                          15. Tavassoli FA: Myoepithelial lesions of the breast. Myoepitheliosis, adenomyoepithelioma, and myoepithelial carcinoma. Am J Surg Pathol. 15(6):554-68, 1991
                                                                          16. Ballance WA et al: Pleomorphic adenoma (benign mixed tumor) of the breast. An immunohistochemical, flow cytometric, and ultrastructural study and review of the literature. Am J Clin Pathol. 93(6):795-801, 1990