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Myofibroma/Myofibromatosis
Catherine C. Roberts, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Infantile myofibromatosis, generalized hamartomatosis, congenital generalized fibromatosis
            • Infantile hemangiopericytoma may represent different stage of same entity
          • Definitions

            • Most common fibrous tumor of infancy comprised of contractile myoid cells around thin-walled blood vessels
              • Solitary lesion = myofibroma
              • Multicentric lesions = myofibromatosis

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Nuclear Medicine Findings

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      Selected References

                                      1. Fang N et al: Myofibroma of the Left Supraspinous Muscle on 18F-FDG PET/CT. Clin Nucl Med. ePub, 2015
                                      2. Hourani R et al: Fibroblastic and myofibroblastic tumors of the head and neck: comprehensive imaging-based review with pathologic correlation. Eur J Radiol. 84(2):250-60, 2015
                                      3. Ma Y et al: Solitary, adult-onset, intraosseous myofibroma of the finger: report of a case and review of literature. Hand (N Y). 10(3):550-4, 2015
                                      4. Davies BM et al: Myofibroma of the cervical spine presenting as brachialgia. J Neurosurg Spine. 21(6):916-8, 2014
                                      5. Weiss SW et al: Fibrous Tumors of Infancy and Childhood. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 264-9, 2008
                                      6. Kransdorf MJ et al: Benign Fibrous and Fibrohistiocytic Tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 205-7, 2006
                                      7. Rubin BP et al: Myofibroma/Myofibromatosis. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 59-61, 2002
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Pathology

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Synonyms

                                                • Infantile myofibromatosis, generalized hamartomatosis, congenital generalized fibromatosis
                                                • Infantile hemangiopericytoma may represent different stage of same entity
                                              • Definitions

                                                • Most common fibrous tumor of infancy comprised of contractile myoid cells around thin-walled blood vessels
                                                  • Solitary lesion = myofibroma
                                                  • Multicentric lesions = myofibromatosis

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Ultrasonographic Findings

                                                        • Nuclear Medicine Findings

                                                          PATHOLOGY

                                                          • General Features

                                                            • Staging, Grading, & Classification

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          Selected References

                                                                          1. Fang N et al: Myofibroma of the Left Supraspinous Muscle on 18F-FDG PET/CT. Clin Nucl Med. ePub, 2015
                                                                          2. Hourani R et al: Fibroblastic and myofibroblastic tumors of the head and neck: comprehensive imaging-based review with pathologic correlation. Eur J Radiol. 84(2):250-60, 2015
                                                                          3. Ma Y et al: Solitary, adult-onset, intraosseous myofibroma of the finger: report of a case and review of literature. Hand (N Y). 10(3):550-4, 2015
                                                                          4. Davies BM et al: Myofibroma of the cervical spine presenting as brachialgia. J Neurosurg Spine. 21(6):916-8, 2014
                                                                          5. Weiss SW et al: Fibrous Tumors of Infancy and Childhood. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 264-9, 2008
                                                                          6. Kransdorf MJ et al: Benign Fibrous and Fibrohistiocytic Tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 205-7, 2006
                                                                          7. Rubin BP et al: Myofibroma/Myofibromatosis. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 59-61, 2002