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Myofibroma/Myofibromatosis
Eric Walker, MD, MHA, FACR, FACHE; Catherine C. Roberts, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Infantile myofibromatosis, generalized hamartomatosis, congenital generalized fibromatosis
            • Myopericytoma (infantile hemangiopericytoma) and myofibrosis are related entities
          • Definitions

            • Most common fibrous tumor of infancy composed of contractile myoid cells around thin-walled blood vessels
              • Solitary lesion = myofibroma
              • Multicentric lesions = myofibromatosis

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Nuclear Medicine Findings

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      Selected References

                                      1. Rashid T et al: Advances in the diagnosis and management of neonatal sarcomas. Clin Perinatol. 48(1):117-45, 2021
                                      2. Yin C et al: Isolated myofibroma imaging manifestations and their correlation with pathology. Asian J Surg. 45(1):622-4, 2021
                                      3. Mentzel TDW et al: Myopericytoma, including myofibroma. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 182-5, 2020
                                      4. Parikh A et al: Diagnostic limitations and considerations in the imaging evaluation of advanced multicentric infantile myofibromatosis. Radiol Case Rep. 15(11):2440-4, 2020
                                      5. Fang N et al: Myofibroma of the left supraspinous muscle on 18F-FDG PET/CT. Clin Nucl Med. 41(4):317-8, 2015
                                      6. Hourani R et al: Fibroblastic and myofibroblastic tumors of the head and neck: comprehensive imaging-based review with pathologic correlation. Eur J Radiol. 84(2):250-60, 2015
                                      7. Ma Y et al: Solitary, adult-onset, intraosseous myofibroma of the finger: report of a case and review of literature. Hand (N Y). 10(3):550-4, 2015
                                      8. Davies BM et al: Myofibroma of the cervical spine presenting as brachialgia. J Neurosurg Spine. 21(6):916-8, 2014
                                      9. Kransdorf MJ et al: Fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 250-5, 2014
                                      10. Weiss SW et al: Fibrous tumors of infancy and childhood. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 264-9, 2008
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Pathology

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Synonyms

                                                • Infantile myofibromatosis, generalized hamartomatosis, congenital generalized fibromatosis
                                                • Myopericytoma (infantile hemangiopericytoma) and myofibrosis are related entities
                                              • Definitions

                                                • Most common fibrous tumor of infancy composed of contractile myoid cells around thin-walled blood vessels
                                                  • Solitary lesion = myofibroma
                                                  • Multicentric lesions = myofibromatosis

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Ultrasonographic Findings

                                                        • Nuclear Medicine Findings

                                                          PATHOLOGY

                                                          • General Features

                                                            • Staging, Grading, & Classification

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          Selected References

                                                                          1. Rashid T et al: Advances in the diagnosis and management of neonatal sarcomas. Clin Perinatol. 48(1):117-45, 2021
                                                                          2. Yin C et al: Isolated myofibroma imaging manifestations and their correlation with pathology. Asian J Surg. 45(1):622-4, 2021
                                                                          3. Mentzel TDW et al: Myopericytoma, including myofibroma. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 182-5, 2020
                                                                          4. Parikh A et al: Diagnostic limitations and considerations in the imaging evaluation of advanced multicentric infantile myofibromatosis. Radiol Case Rep. 15(11):2440-4, 2020
                                                                          5. Fang N et al: Myofibroma of the left supraspinous muscle on 18F-FDG PET/CT. Clin Nucl Med. 41(4):317-8, 2015
                                                                          6. Hourani R et al: Fibroblastic and myofibroblastic tumors of the head and neck: comprehensive imaging-based review with pathologic correlation. Eur J Radiol. 84(2):250-60, 2015
                                                                          7. Ma Y et al: Solitary, adult-onset, intraosseous myofibroma of the finger: report of a case and review of literature. Hand (N Y). 10(3):550-4, 2015
                                                                          8. Davies BM et al: Myofibroma of the cervical spine presenting as brachialgia. J Neurosurg Spine. 21(6):916-8, 2014
                                                                          9. Kransdorf MJ et al: Fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 250-5, 2014
                                                                          10. Weiss SW et al: Fibrous tumors of infancy and childhood. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 264-9, 2008