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KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
- Myxoid malignant fibrous histiocytoma; fibrosarcoma, myxoid type
Definitions
- Common fibroblastic soft tissue sarcoma involving elderly patients, with wide range of appearances depending on cellularity and myxoid content
- Reclassified as distinct entity by World Health Organization in 2002
- Formerly malignant fibrous histiocytoma variant
- Not same entity as fibromyxoid sarcoma
- Common fibroblastic soft tissue sarcoma involving elderly patients, with wide range of appearances depending on cellularity and myxoid content
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Kikuta K et al: An analysis of factors related to the tail-like pattern of myxofibrosarcoma seen on MRI. Skeletal Radiol. 44(1):55-62, 2015
- Petscavage-Thomas JM et al: Soft-tissue myxomatous lesions: review of salient imaging features with pathologic comparison. Radiographics. 34(4):964-80, 2014
- Lefkowitz RA et al: Myxofibrosarcoma: prevalence and diagnostic value of the "tail sign" on magnetic resonance imaging. Skeletal Radiol. 42(6):809-18, 2013
- Kaya M et al: MRI and histological evaluation of the infiltrative growth pattern of myxofibrosarcoma. Skeletal Radiol. 37(12):1085-90, 2008
- Weiss SW et al: Fibrosarcoma. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 312-16, 2008
- Lin CN et al: Prognostic factors of myxofibrosarcomas: implications of margin status, tumor necrosis, and mitotic rate on survival. J Surg Oncol. 93(4):294-303, 2006
- Kransdorf MJ et al: Malignant fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 277-8, 2006
- Manoso MW et al: Infiltrative MRI pattern and incomplete initial surgery compromise local control of myxofibrosarcoma. Clin Orthop Relat Res. 450:89-94, 2006
- Huang HY et al: Low-grade myxofibrosarcoma: a clinicopathologic analysis of 49 cases treated at a single institution with simultaneous assessment of the efficacy of 3-tier and 4-tier grading systems. Hum Pathol. 35(5):612-21, 2004
- Mentzel T et al: Myxofibrosarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 102-3, 2002
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
- Myxoid malignant fibrous histiocytoma; fibrosarcoma, myxoid type
Definitions
- Common fibroblastic soft tissue sarcoma involving elderly patients, with wide range of appearances depending on cellularity and myxoid content
- Reclassified as distinct entity by World Health Organization in 2002
- Formerly malignant fibrous histiocytoma variant
- Not same entity as fibromyxoid sarcoma
- Common fibroblastic soft tissue sarcoma involving elderly patients, with wide range of appearances depending on cellularity and myxoid content
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Kikuta K et al: An analysis of factors related to the tail-like pattern of myxofibrosarcoma seen on MRI. Skeletal Radiol. 44(1):55-62, 2015
- Petscavage-Thomas JM et al: Soft-tissue myxomatous lesions: review of salient imaging features with pathologic comparison. Radiographics. 34(4):964-80, 2014
- Lefkowitz RA et al: Myxofibrosarcoma: prevalence and diagnostic value of the "tail sign" on magnetic resonance imaging. Skeletal Radiol. 42(6):809-18, 2013
- Kaya M et al: MRI and histological evaluation of the infiltrative growth pattern of myxofibrosarcoma. Skeletal Radiol. 37(12):1085-90, 2008
- Weiss SW et al: Fibrosarcoma. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 312-16, 2008
- Lin CN et al: Prognostic factors of myxofibrosarcomas: implications of margin status, tumor necrosis, and mitotic rate on survival. J Surg Oncol. 93(4):294-303, 2006
- Kransdorf MJ et al: Malignant fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 277-8, 2006
- Manoso MW et al: Infiltrative MRI pattern and incomplete initial surgery compromise local control of myxofibrosarcoma. Clin Orthop Relat Res. 450:89-94, 2006
- Huang HY et al: Low-grade myxofibrosarcoma: a clinicopathologic analysis of 49 cases treated at a single institution with simultaneous assessment of the efficacy of 3-tier and 4-tier grading systems. Hum Pathol. 35(5):612-21, 2004
- Mentzel T et al: Myxofibrosarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 102-3, 2002
