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Myxofibrosarcoma
Catherine C. Roberts, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Synonyms

              • Myxoid malignant fibrous histiocytoma; fibrosarcoma, myxoid type
            • Definitions

              • Common fibroblastic soft tissue sarcoma involving elderly patients, with wide range of appearances depending on cellularity and myxoid content
                • Reclassified as distinct entity by World Health Organization in 2002
                • Formerly malignant fibrous histiocytoma variant
                • Not same entity as fibromyxoid sarcoma

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Kikuta K et al: An analysis of factors related to the tail-like pattern of myxofibrosarcoma seen on MRI. Skeletal Radiol. 44(1):55-62, 2015
                                      2. Petscavage-Thomas JM et al: Soft-tissue myxomatous lesions: review of salient imaging features with pathologic comparison. Radiographics. 34(4):964-80, 2014
                                      3. Lefkowitz RA et al: Myxofibrosarcoma: prevalence and diagnostic value of the "tail sign" on magnetic resonance imaging. Skeletal Radiol. 42(6):809-18, 2013
                                      4. Kaya M et al: MRI and histological evaluation of the infiltrative growth pattern of myxofibrosarcoma. Skeletal Radiol. 37(12):1085-90, 2008
                                      5. Weiss SW et al: Fibrosarcoma. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 312-16, 2008
                                      6. Lin CN et al: Prognostic factors of myxofibrosarcomas: implications of margin status, tumor necrosis, and mitotic rate on survival. J Surg Oncol. 93(4):294-303, 2006
                                      7. Kransdorf MJ et al: Malignant fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 277-8, 2006
                                      8. Manoso MW et al: Infiltrative MRI pattern and incomplete initial surgery compromise local control of myxofibrosarcoma. Clin Orthop Relat Res. 450:89-94, 2006
                                      9. Huang HY et al: Low-grade myxofibrosarcoma: a clinicopathologic analysis of 49 cases treated at a single institution with simultaneous assessment of the efficacy of 3-tier and 4-tier grading systems. Hum Pathol. 35(5):612-21, 2004
                                      10. Mentzel T et al: Myxofibrosarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 102-3, 2002
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Pathology

                                            • Clinical Issues

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Synonyms

                                                  • Myxoid malignant fibrous histiocytoma; fibrosarcoma, myxoid type
                                                • Definitions

                                                  • Common fibroblastic soft tissue sarcoma involving elderly patients, with wide range of appearances depending on cellularity and myxoid content
                                                    • Reclassified as distinct entity by World Health Organization in 2002
                                                    • Formerly malignant fibrous histiocytoma variant
                                                    • Not same entity as fibromyxoid sarcoma

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Gross Pathologic & Surgical Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Kikuta K et al: An analysis of factors related to the tail-like pattern of myxofibrosarcoma seen on MRI. Skeletal Radiol. 44(1):55-62, 2015
                                                                          2. Petscavage-Thomas JM et al: Soft-tissue myxomatous lesions: review of salient imaging features with pathologic comparison. Radiographics. 34(4):964-80, 2014
                                                                          3. Lefkowitz RA et al: Myxofibrosarcoma: prevalence and diagnostic value of the "tail sign" on magnetic resonance imaging. Skeletal Radiol. 42(6):809-18, 2013
                                                                          4. Kaya M et al: MRI and histological evaluation of the infiltrative growth pattern of myxofibrosarcoma. Skeletal Radiol. 37(12):1085-90, 2008
                                                                          5. Weiss SW et al: Fibrosarcoma. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 312-16, 2008
                                                                          6. Lin CN et al: Prognostic factors of myxofibrosarcomas: implications of margin status, tumor necrosis, and mitotic rate on survival. J Surg Oncol. 93(4):294-303, 2006
                                                                          7. Kransdorf MJ et al: Malignant fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 277-8, 2006
                                                                          8. Manoso MW et al: Infiltrative MRI pattern and incomplete initial surgery compromise local control of myxofibrosarcoma. Clin Orthop Relat Res. 450:89-94, 2006
                                                                          9. Huang HY et al: Low-grade myxofibrosarcoma: a clinicopathologic analysis of 49 cases treated at a single institution with simultaneous assessment of the efficacy of 3-tier and 4-tier grading systems. Hum Pathol. 35(5):612-21, 2004
                                                                          10. Mentzel T et al: Myxofibrosarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 102-3, 2002