Malignant tumor composed of uniform, round to oval cells with variable numbers of small lipoblasts, set in myxoid stroma with branching capillary vasculature
Also includes more cellular, high-grade tumors formerly known as round cell liposarcoma
IMAGING
General Features
Imaging Recommendations
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Lansu J et al: A moderate dose of preoperative radiotherapy may improve resectability in myxoid liposarcoma. Eur J Surg Oncol. 47(10):2633-9, 2021
Saifuddin A et al: Magnetic resonance imaging of trunk and extremity myxoid liposarcoma: diagnosis, staging, and response to treatment. Skeletal Radiol. 50(10):1963-80, 2021
Thway K et al: Myxoid liposarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 42-4, 2020
Wortman JR et al: Neoadjuvant radiation in primary extremity liposarcoma: correlation of MRI features with histopathology. Eur Radiol. 26(5):1226-34, 2015
Mankin HJ et al: Liposarcoma: a soft tissue tumor with many presentations. Musculoskelet Surg. 98(3):171-7, 2014
Petscavage-Thomas JM et al: Soft-tissue myxomatous lesions: review of salient imaging features with pathologic comparison. Radiographics. 34(4):964-80, 2014
Kransdorf MJ et al: Lipomatous tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 156-70, 2014
Walker E et al: Dilemmas in distinguishing between tumor and the posttraumatic lesion with surgical or pathologic correlation. Clin Sports Med. 32(3):559-76, 2013
Walker EA et al: Magnetic resonance imaging of malignant soft tissue neoplasms in the adult. Radiol Clin North Am. 49(6):1219-34, vi, 2011
Walker EA et al: Magnetic resonance imaging of soft-tissue masses. Semin Roentgenol. 45(4):277-97, 2010
Craig WD et al: Fat-containing lesions of the retroperitoneum: radiologic-pathologic correlation. Radiographics. 29(1):261-90, 2009
Sheah K et al: Metastatic myxoid liposarcomas: imaging and histopathologic findings. Skeletal Radiol. 37(3):251-8, 2008
Weiss SW et al: Liposarcoma. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 498-509, 2008
Murphey MD et al: From the archives of the AFIP: imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation. Radiographics. 25(5):1371-95, 2005
Antonescu et al: Myxoid liposarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 40-3, 2002
Related Anatomy
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References
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Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
Round cell liposarcoma
Definitions
Malignant tumor composed of uniform, round to oval cells with variable numbers of small lipoblasts, set in myxoid stroma with branching capillary vasculature
Also includes more cellular, high-grade tumors formerly known as round cell liposarcoma
IMAGING
General Features
Imaging Recommendations
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Lansu J et al: A moderate dose of preoperative radiotherapy may improve resectability in myxoid liposarcoma. Eur J Surg Oncol. 47(10):2633-9, 2021
Saifuddin A et al: Magnetic resonance imaging of trunk and extremity myxoid liposarcoma: diagnosis, staging, and response to treatment. Skeletal Radiol. 50(10):1963-80, 2021
Thway K et al: Myxoid liposarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 42-4, 2020
Wortman JR et al: Neoadjuvant radiation in primary extremity liposarcoma: correlation of MRI features with histopathology. Eur Radiol. 26(5):1226-34, 2015
Mankin HJ et al: Liposarcoma: a soft tissue tumor with many presentations. Musculoskelet Surg. 98(3):171-7, 2014
Petscavage-Thomas JM et al: Soft-tissue myxomatous lesions: review of salient imaging features with pathologic comparison. Radiographics. 34(4):964-80, 2014
Kransdorf MJ et al: Lipomatous tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 156-70, 2014
Walker E et al: Dilemmas in distinguishing between tumor and the posttraumatic lesion with surgical or pathologic correlation. Clin Sports Med. 32(3):559-76, 2013
Walker EA et al: Magnetic resonance imaging of malignant soft tissue neoplasms in the adult. Radiol Clin North Am. 49(6):1219-34, vi, 2011
Walker EA et al: Magnetic resonance imaging of soft-tissue masses. Semin Roentgenol. 45(4):277-97, 2010
Craig WD et al: Fat-containing lesions of the retroperitoneum: radiologic-pathologic correlation. Radiographics. 29(1):261-90, 2009
Sheah K et al: Metastatic myxoid liposarcomas: imaging and histopathologic findings. Skeletal Radiol. 37(3):251-8, 2008
Weiss SW et al: Liposarcoma. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 498-509, 2008
Murphey MD et al: From the archives of the AFIP: imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation. Radiographics. 25(5):1371-95, 2005
Antonescu et al: Myxoid liposarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 40-3, 2002
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