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Myxoid Liposarcoma
Eric Walker, MD, MHA, FACR, FACHE; Catherine C. Roberts, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Round cell liposarcoma
            • Definitions

              • Malignant tumor composed of uniform, round to oval cells with variable numbers of small lipoblasts, set in myxoid stroma with branching capillary vasculature
              • Also includes more cellular, high-grade tumors formerly known as round cell liposarcoma

            IMAGING

            • General Features

              • Imaging Recommendations

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Ultrasonographic Findings

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Lansu J et al: A moderate dose of preoperative radiotherapy may improve resectability in myxoid liposarcoma. Eur J Surg Oncol. 47(10):2633-9, 2021
                                          2. Saifuddin A et al: Magnetic resonance imaging of trunk and extremity myxoid liposarcoma: diagnosis, staging, and response to treatment. Skeletal Radiol. 50(10):1963-80, 2021
                                          3. Thway K et al: Myxoid liposarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 42-4, 2020
                                          4. Wortman JR et al: Neoadjuvant radiation in primary extremity liposarcoma: correlation of MRI features with histopathology. Eur Radiol. 26(5):1226-34, 2015
                                          5. Mankin HJ et al: Liposarcoma: a soft tissue tumor with many presentations. Musculoskelet Surg. 98(3):171-7, 2014
                                          6. Petscavage-Thomas JM et al: Soft-tissue myxomatous lesions: review of salient imaging features with pathologic comparison. Radiographics. 34(4):964-80, 2014
                                          7. Kransdorf MJ et al: Lipomatous tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 156-70, 2014
                                          8. Walker E et al: Dilemmas in distinguishing between tumor and the posttraumatic lesion with surgical or pathologic correlation. Clin Sports Med. 32(3):559-76, 2013
                                          9. Walker EA et al: Magnetic resonance imaging of malignant soft tissue neoplasms in the adult. Radiol Clin North Am. 49(6):1219-34, vi, 2011
                                          10. Walker EA et al: Magnetic resonance imaging of soft-tissue masses. Semin Roentgenol. 45(4):277-97, 2010
                                          11. Craig WD et al: Fat-containing lesions of the retroperitoneum: radiologic-pathologic correlation. Radiographics. 29(1):261-90, 2009
                                          12. Sheah K et al: Metastatic myxoid liposarcomas: imaging and histopathologic findings. Skeletal Radiol. 37(3):251-8, 2008
                                          13. Weiss SW et al: Liposarcoma. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 498-509, 2008
                                          14. Murphey MD et al: From the archives of the AFIP: imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation. Radiographics. 25(5):1371-95, 2005
                                          15. Antonescu et al: Myxoid liposarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 40-3, 2002
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Synonyms

                                                      • Round cell liposarcoma
                                                    • Definitions

                                                      • Malignant tumor composed of uniform, round to oval cells with variable numbers of small lipoblasts, set in myxoid stroma with branching capillary vasculature
                                                      • Also includes more cellular, high-grade tumors formerly known as round cell liposarcoma

                                                    IMAGING

                                                    • General Features

                                                      • Imaging Recommendations

                                                        • Radiographic Findings

                                                          • CT Findings

                                                            • MR Findings

                                                              • Ultrasonographic Findings

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Lansu J et al: A moderate dose of preoperative radiotherapy may improve resectability in myxoid liposarcoma. Eur J Surg Oncol. 47(10):2633-9, 2021
                                                                                  2. Saifuddin A et al: Magnetic resonance imaging of trunk and extremity myxoid liposarcoma: diagnosis, staging, and response to treatment. Skeletal Radiol. 50(10):1963-80, 2021
                                                                                  3. Thway K et al: Myxoid liposarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 42-4, 2020
                                                                                  4. Wortman JR et al: Neoadjuvant radiation in primary extremity liposarcoma: correlation of MRI features with histopathology. Eur Radiol. 26(5):1226-34, 2015
                                                                                  5. Mankin HJ et al: Liposarcoma: a soft tissue tumor with many presentations. Musculoskelet Surg. 98(3):171-7, 2014
                                                                                  6. Petscavage-Thomas JM et al: Soft-tissue myxomatous lesions: review of salient imaging features with pathologic comparison. Radiographics. 34(4):964-80, 2014
                                                                                  7. Kransdorf MJ et al: Lipomatous tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 156-70, 2014
                                                                                  8. Walker E et al: Dilemmas in distinguishing between tumor and the posttraumatic lesion with surgical or pathologic correlation. Clin Sports Med. 32(3):559-76, 2013
                                                                                  9. Walker EA et al: Magnetic resonance imaging of malignant soft tissue neoplasms in the adult. Radiol Clin North Am. 49(6):1219-34, vi, 2011
                                                                                  10. Walker EA et al: Magnetic resonance imaging of soft-tissue masses. Semin Roentgenol. 45(4):277-97, 2010
                                                                                  11. Craig WD et al: Fat-containing lesions of the retroperitoneum: radiologic-pathologic correlation. Radiographics. 29(1):261-90, 2009
                                                                                  12. Sheah K et al: Metastatic myxoid liposarcomas: imaging and histopathologic findings. Skeletal Radiol. 37(3):251-8, 2008
                                                                                  13. Weiss SW et al: Liposarcoma. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 498-509, 2008
                                                                                  14. Murphey MD et al: From the archives of the AFIP: imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation. Radiographics. 25(5):1371-95, 2005
                                                                                  15. Antonescu et al: Myxoid liposarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 40-3, 2002