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Nabothian Cysts
Maryam Rezvani, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Endocervical gland cysts
              • Retention cysts of cervix
              • Tunnel clusters
            • Definitions

              • Nabothian cysts and endocervical gland cysts
                • Mucinous endocervical gland cysts due to obstruction by overgrowth of squamous epithelium at their necks
              • Tunnel clusters
                • Specific type of nabothian cyst characterized by complex multicystic dilation of endocervical glands

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Other Modality Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Liu S et al: Nabothian cyst associated with high false-positive incidence of iodine-131 uptake in whole-body scans after treatment for differentiated thyroid cancer. Nucl Med Commun. 34(12):1204-7, 2013
                                            2. Nigam A et al: Large nabothian cyst: a rare cause of nulliparous prolapse. Case Rep Obstet Gynecol. 2012:192526, 2012
                                            3. Bin Park S et al: Multilocular cystic lesions in the uterine cervix: broad spectrum of imaging features and pathologic correlation. AJR Am J Roentgenol. 195(2):517-23, 2010
                                            4. Sugiyama K et al: MR findings of pseudoneoplastic lesions in the uterine cervix mimicking adenoma malignum. Br J Radiol. 80(959):878-83, 2007
                                            5. Oguri H et al: MRI of endocervical glandular disorders: three cases of a deep nabothian cyst and three cases of a minimal-deviation adenocarcinoma. Magn Reson Imaging. 22(9):1333-7, 2004
                                            6. Okamoto Y et al: MR imaging of the uterine cervix: imaging-pathologic correlation. Radiographics. 23(2):425-45; quiz 534-5, 2003
                                            7. Li H et al: Markedly high signal intensity lesions in the uterine cervix on T2-weighted imaging: differentiation between mucin-producing carcinomas and nabothian cysts. Radiat Med. 17(2):137-43, 1999
                                            8. Pelosi MA 3rd et al: Symptomatic cervical macrocyst as a late complication of subtotal hysterectomy. A case report. J Reprod Med. 44(6):567-70, 1999
                                            9. Umesaki N et al: Power Doppler findings of adenoma malignum of uterine cervix. Gynecol Obstet Invest. 45(3):213-6, 1998
                                            10. Jones MA et al: Endocervical type A (noncystic) tunnel clusters with cytologic atypia. A report of 14 cases. Am J Surg Pathol. 20(11):1312-8, 1996
                                            11. Daya D et al: Florid deep glands of the uterine cervix. Another mimic of adenoma malignum. Am J Clin Pathol. 103(5):614-7, 1995
                                            12. Yamashita Y et al: Adenoma malignum: MR appearances mimicking nabothian cysts. AJR Am J Roentgenol. 162(3):649-50, 1994
                                            13. Togashi K et al: CT and MR demonstration of nabothian cysts mimicking a cystic adnexal mass. J Comput Assist Tomogr. 11(6):1091-2, 1987
                                            14. Fogel SR et al: Sonography of Nabothian cysts. AJR Am J Roentgenol. 138(5):927-30, 1982
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Synonyms

                                                        • Endocervical gland cysts
                                                        • Retention cysts of cervix
                                                        • Tunnel clusters
                                                      • Definitions

                                                        • Nabothian cysts and endocervical gland cysts
                                                          • Mucinous endocervical gland cysts due to obstruction by overgrowth of squamous epithelium at their necks
                                                        • Tunnel clusters
                                                          • Specific type of nabothian cyst characterized by complex multicystic dilation of endocervical glands

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Ultrasonographic Findings

                                                              • Other Modality Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Liu S et al: Nabothian cyst associated with high false-positive incidence of iodine-131 uptake in whole-body scans after treatment for differentiated thyroid cancer. Nucl Med Commun. 34(12):1204-7, 2013
                                                                                      2. Nigam A et al: Large nabothian cyst: a rare cause of nulliparous prolapse. Case Rep Obstet Gynecol. 2012:192526, 2012
                                                                                      3. Bin Park S et al: Multilocular cystic lesions in the uterine cervix: broad spectrum of imaging features and pathologic correlation. AJR Am J Roentgenol. 195(2):517-23, 2010
                                                                                      4. Sugiyama K et al: MR findings of pseudoneoplastic lesions in the uterine cervix mimicking adenoma malignum. Br J Radiol. 80(959):878-83, 2007
                                                                                      5. Oguri H et al: MRI of endocervical glandular disorders: three cases of a deep nabothian cyst and three cases of a minimal-deviation adenocarcinoma. Magn Reson Imaging. 22(9):1333-7, 2004
                                                                                      6. Okamoto Y et al: MR imaging of the uterine cervix: imaging-pathologic correlation. Radiographics. 23(2):425-45; quiz 534-5, 2003
                                                                                      7. Li H et al: Markedly high signal intensity lesions in the uterine cervix on T2-weighted imaging: differentiation between mucin-producing carcinomas and nabothian cysts. Radiat Med. 17(2):137-43, 1999
                                                                                      8. Pelosi MA 3rd et al: Symptomatic cervical macrocyst as a late complication of subtotal hysterectomy. A case report. J Reprod Med. 44(6):567-70, 1999
                                                                                      9. Umesaki N et al: Power Doppler findings of adenoma malignum of uterine cervix. Gynecol Obstet Invest. 45(3):213-6, 1998
                                                                                      10. Jones MA et al: Endocervical type A (noncystic) tunnel clusters with cytologic atypia. A report of 14 cases. Am J Surg Pathol. 20(11):1312-8, 1996
                                                                                      11. Daya D et al: Florid deep glands of the uterine cervix. Another mimic of adenoma malignum. Am J Clin Pathol. 103(5):614-7, 1995
                                                                                      12. Yamashita Y et al: Adenoma malignum: MR appearances mimicking nabothian cysts. AJR Am J Roentgenol. 162(3):649-50, 1994
                                                                                      13. Togashi K et al: CT and MR demonstration of nabothian cysts mimicking a cystic adnexal mass. J Comput Assist Tomogr. 11(6):1091-2, 1987
                                                                                      14. Fogel SR et al: Sonography of Nabothian cysts. AJR Am J Roentgenol. 138(5):927-30, 1982