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Nasal Glioma
Michelle A. Michel, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Nasal glioma (NG)
                • Extranasal glioma (ENG), intranasal glioma (ING)
            • Synonyms

              • Nasal cerebral heterotopia, glial heterotopia
            • Definitions

              • Developmental mass of dysplastic neurogenic tissue sequestered & isolated from subarachnoid space
                • "Glioma" is misnomer as this is nonneoplastic tissue
                • Best thought of as cephalocele without intracranial connection to brain

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Gnagi SH et al: Nasal obstruction in newborns. Pediatr Clin North Am. 60(4):903-22, 2013
                                        2. Husein OF et al: Neuroglial heterotopia causing neonatal airway obstruction: presentation, management, and literature review. Eur J Pediatr. 167(12):1351-5, 2008
                                        3. Riffaud L et al: Glial heterotopia of the face. J Pediatr Surg. 43(12):e1-3, 2008
                                        4. De Biasio P et al: Prenatal diagnosis of a nasal glioma in the mid trimester. Ultrasound Obstet Gynecol. 27(5):571-3, 2006
                                        5. Hedlund G: Congenital frontonasal masses: developmental anatomy, malformations, and MR imaging. Pediatr Radiol. 36(7):647-62; quiz 726-7, 2006
                                        6. Khanna G et al: Causes of facial swelling in pediatric patients: correlation of clinical and radiologic findings. Radiographics. 26(1):157-71, 2006
                                        7. Huisman TA et al: Developmental nasal midline masses in children: neuroradiological evaluation. Eur Radiol. 14(2):243-9, 2004
                                        8. Penner CR et al: Nasal glial heterotopia. Ear Nose Throat J. 83(2):92-3, 2004
                                        9. Restrepo S et al: Nasal glioma. Ear Nose Throat J. 83(2):88-9, 2004
                                        10. Dasgupta NR et al: Nasal gliomas: identification and differentiation from hemangiomas. J Craniofac Surg. 14(5):736-8, 2003
                                        11. Penner CR et al: Nasal glial heterotopia: a clinicopathologic and immunophenotypic analysis of 10 cases with a review of the literature. Ann Diagn Pathol. 7(6):354-9, 2003
                                        12. Rahbar R et al: Nasal glioma and encephalocele: diagnosis and management. Laryngoscope. 113(12):2069-77, 2003
                                        13. Cerda-Nicolas M et al: Nasal glioma or nasal glial heterotopia? Morphological, immunohistochemical and ultrastructural study of two cases. Clin Neuropathol. 21(2):66-71, 2002
                                        14. Jartti PH et al: MR of a nasal glioma in a young infant. Acta Radiol. 43(2):141-3, 2002
                                        15. Yokoi H et al: Endoscopic treatment of so-called intranasal glioma. Rhinology. 40(4):217-9, 2002
                                        16. Hoeger PH et al: Nasal glioma presenting as capillary haemangioma. Eur J Pediatr. 160(2):84-7, 2001
                                        17. Shah J et al: Pedunculated nasal glioma: MRI features and review of the literature. J Postgrad Med. 45(1):15-7, 1999
                                        18. Yokoyama M et al: Endoscopic management of nasal glioma in infancy. Int J Pediatr Otorhinolaryngol. 51(1):51-4, 1999
                                        19. Belden CJ et al: The developing anterior skull base: CT appearance from birth to 2 years of age. AJNR Am J Neuroradiol. 18(5):811-8, 1997
                                        20. Pensler JM et al: Craniofacial gliomas. Plast Reconstr Surg. 98(1):27-30, 1996
                                        21. Barkovich AJ et al: Congenital nasal masses: CT and MR imaging features in 16 cases. AJNR Am J Neuroradiol. 12(1):105-16, 1991
                                        22. Kennard CD et al: Congenital midline nasal masses: diagnosis and management. J Dermatol Surg Oncol. 16(11):1025-36, 1990
                                        23. Morgan DW et al: Developmental nasal anomalies. J Laryngol Otol. 104(5):394-403, 1990
                                        24. Younus M et al: Nasal glioma and encephalocele: two separate entities. Report of two cases. J Neurosurg. 64(3):516-9, 1986
                                        25. Whitaker SR et al: Nasal glioma. Arch Otolaryngol. 107(9):550-4, 1981
                                        26. Hughes GB et al: Management of the congenital midline nasal mass: a review. Head Neck Surg. 2(3):222-33, 1980
                                        27. Hirsh LF et al: Nasal glioma. J Neurosurg. 46(1):85-91, 1977
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Nasal glioma (NG)
                                                      • Extranasal glioma (ENG), intranasal glioma (ING)
                                                  • Synonyms

                                                    • Nasal cerebral heterotopia, glial heterotopia
                                                  • Definitions

                                                    • Developmental mass of dysplastic neurogenic tissue sequestered & isolated from subarachnoid space
                                                      • "Glioma" is misnomer as this is nonneoplastic tissue
                                                      • Best thought of as cephalocele without intracranial connection to brain

                                                  IMAGING

                                                  • General Features

                                                    • CT Findings

                                                      • MR Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          DIAGNOSTIC CHECKLIST

                                                                          • Consider

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Gnagi SH et al: Nasal obstruction in newborns. Pediatr Clin North Am. 60(4):903-22, 2013
                                                                              2. Husein OF et al: Neuroglial heterotopia causing neonatal airway obstruction: presentation, management, and literature review. Eur J Pediatr. 167(12):1351-5, 2008
                                                                              3. Riffaud L et al: Glial heterotopia of the face. J Pediatr Surg. 43(12):e1-3, 2008
                                                                              4. De Biasio P et al: Prenatal diagnosis of a nasal glioma in the mid trimester. Ultrasound Obstet Gynecol. 27(5):571-3, 2006
                                                                              5. Hedlund G: Congenital frontonasal masses: developmental anatomy, malformations, and MR imaging. Pediatr Radiol. 36(7):647-62; quiz 726-7, 2006
                                                                              6. Khanna G et al: Causes of facial swelling in pediatric patients: correlation of clinical and radiologic findings. Radiographics. 26(1):157-71, 2006
                                                                              7. Huisman TA et al: Developmental nasal midline masses in children: neuroradiological evaluation. Eur Radiol. 14(2):243-9, 2004
                                                                              8. Penner CR et al: Nasal glial heterotopia. Ear Nose Throat J. 83(2):92-3, 2004
                                                                              9. Restrepo S et al: Nasal glioma. Ear Nose Throat J. 83(2):88-9, 2004
                                                                              10. Dasgupta NR et al: Nasal gliomas: identification and differentiation from hemangiomas. J Craniofac Surg. 14(5):736-8, 2003
                                                                              11. Penner CR et al: Nasal glial heterotopia: a clinicopathologic and immunophenotypic analysis of 10 cases with a review of the literature. Ann Diagn Pathol. 7(6):354-9, 2003
                                                                              12. Rahbar R et al: Nasal glioma and encephalocele: diagnosis and management. Laryngoscope. 113(12):2069-77, 2003
                                                                              13. Cerda-Nicolas M et al: Nasal glioma or nasal glial heterotopia? Morphological, immunohistochemical and ultrastructural study of two cases. Clin Neuropathol. 21(2):66-71, 2002
                                                                              14. Jartti PH et al: MR of a nasal glioma in a young infant. Acta Radiol. 43(2):141-3, 2002
                                                                              15. Yokoi H et al: Endoscopic treatment of so-called intranasal glioma. Rhinology. 40(4):217-9, 2002
                                                                              16. Hoeger PH et al: Nasal glioma presenting as capillary haemangioma. Eur J Pediatr. 160(2):84-7, 2001
                                                                              17. Shah J et al: Pedunculated nasal glioma: MRI features and review of the literature. J Postgrad Med. 45(1):15-7, 1999
                                                                              18. Yokoyama M et al: Endoscopic management of nasal glioma in infancy. Int J Pediatr Otorhinolaryngol. 51(1):51-4, 1999
                                                                              19. Belden CJ et al: The developing anterior skull base: CT appearance from birth to 2 years of age. AJNR Am J Neuroradiol. 18(5):811-8, 1997
                                                                              20. Pensler JM et al: Craniofacial gliomas. Plast Reconstr Surg. 98(1):27-30, 1996
                                                                              21. Barkovich AJ et al: Congenital nasal masses: CT and MR imaging features in 16 cases. AJNR Am J Neuroradiol. 12(1):105-16, 1991
                                                                              22. Kennard CD et al: Congenital midline nasal masses: diagnosis and management. J Dermatol Surg Oncol. 16(11):1025-36, 1990
                                                                              23. Morgan DW et al: Developmental nasal anomalies. J Laryngol Otol. 104(5):394-403, 1990
                                                                              24. Younus M et al: Nasal glioma and encephalocele: two separate entities. Report of two cases. J Neurosurg. 64(3):516-9, 1986
                                                                              25. Whitaker SR et al: Nasal glioma. Arch Otolaryngol. 107(9):550-4, 1981
                                                                              26. Hughes GB et al: Management of the congenital midline nasal mass: a review. Head Neck Surg. 2(3):222-33, 1980
                                                                              27. Hirsh LF et al: Nasal glioma. J Neurosurg. 46(1):85-91, 1977