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Nasal Glioma
Surjith Vattoth, MD, FRCR; Bernadette L. Koch, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Nasal glioma (NG)
                  • Extranasal glioma (ENG), intranasal glioma (ING)
              • Synonyms

                • Nasal cerebral heterotopia, glial heterotopia
              • Definitions

                • Developmental mass of dysplastic neurogenic tissue sequestered & isolated from subarachnoid space
                  • Glioma is misnomer as this is nonneoplastic tissue
                  • Best thought of as cephalocele without intracranial connection to brain

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Charles NC et al: Nasal glioma: a rare cause of congenital inner canthal swelling. Ophthalmic Plast Reconstr Surg. 34(3):e93-5, 2018
                                          2. Méndez-Gallart R et al: Prenatal diagnosis of fetal nasal glioma. J Obstet Gynaecol Can. 40(5):523-4, 2018
                                          3. Gnagi SH et al: Nasal obstruction in newborns. Pediatr Clin North Am. 60(4):903-22, 2013
                                          4. Hughes DC et al: Dimensions and ossification of the normal anterior cranial fossa in children. AJNR Am J Neuroradiol. 31(7):1268-72, 2010
                                          5. Husein OF et al: Neuroglial heterotopia causing neonatal airway obstruction: presentation, management, and literature review. Eur J Pediatr. 167(12):1351-5, 2008
                                          6. Riffaud L et al: Glial heterotopia of the face. J Pediatr Surg. 43(12):e1-3, 2008
                                          7. De Biasio P et al: Prenatal diagnosis of a nasal glioma in the mid trimester. Ultrasound Obstet Gynecol. 27(5):571-3, 2006
                                          8. Hedlund G: Congenital frontonasal masses: developmental anatomy, malformations, and MR imaging. Pediatr Radiol. 36(7):647-62; quiz 726-7, 2006
                                          9. Huisman TA et al: Developmental nasal midline masses in children: neuroradiological evaluation. Eur Radiol. 14(2):243-9, 2004
                                          10. Penner CR et al: Nasal glial heterotopia. Ear Nose Throat J. 83(2):92-3, 2004
                                          11. Restrepo S et al: Nasal glioma. Ear Nose Throat J. 83(2):88-9, 2004
                                          12. Penner CR et al: Nasal glial heterotopia: a clinicopathologic and immunophenotypic analysis of 10 cases with a review of the literature. Ann Diagn Pathol. 7(6):354-9, 2003
                                          13. Rahbar R et al: Nasal glioma and encephalocele: diagnosis and management. Laryngoscope. 113(12):2069-77, 2003
                                          14. Hoeger PH et al: Nasal glioma presenting as capillary haemangioma. Eur J Pediatr. 160(2):84-7, 2001
                                          15. Shah J et al: Pedunculated nasal glioma: MRI features and review of the literature. J Postgrad Med. 45(1):15-7, 1999
                                          16. Belden CJ et al: The developing anterior skull base: CT appearance from birth to 2 years of age. AJNR Am J Neuroradiol. 18(5):811-8, 1997
                                          17. Barkovich AJ et al: Congenital nasal masses: CT and MR imaging features in 16 cases. AJNR Am J Neuroradiol. 12(1):105-16, 1991
                                          18. Kennard CD et al: Congenital midline nasal masses: diagnosis and management. J Dermatol Surg Oncol. 16(11):1025-36, 1990
                                          19. Morgan DW et al: Developmental nasal anomalies. J Laryngol Otol. 104(5):394-403, 1990
                                          20. Younus M et al: Nasal glioma and encephalocele: two separate entities. Report of two cases. J Neurosurg. 64(3):516-9, 1986
                                          21. Whitaker SR et al: Nasal glioma. Arch Otolaryngol. 107(9):550-4, 1981
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Nasal glioma (NG)
                                                          • Extranasal glioma (ENG), intranasal glioma (ING)
                                                      • Synonyms

                                                        • Nasal cerebral heterotopia, glial heterotopia
                                                      • Definitions

                                                        • Developmental mass of dysplastic neurogenic tissue sequestered & isolated from subarachnoid space
                                                          • Glioma is misnomer as this is nonneoplastic tissue
                                                          • Best thought of as cephalocele without intracranial connection to brain

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Charles NC et al: Nasal glioma: a rare cause of congenital inner canthal swelling. Ophthalmic Plast Reconstr Surg. 34(3):e93-5, 2018
                                                                                  2. Méndez-Gallart R et al: Prenatal diagnosis of fetal nasal glioma. J Obstet Gynaecol Can. 40(5):523-4, 2018
                                                                                  3. Gnagi SH et al: Nasal obstruction in newborns. Pediatr Clin North Am. 60(4):903-22, 2013
                                                                                  4. Hughes DC et al: Dimensions and ossification of the normal anterior cranial fossa in children. AJNR Am J Neuroradiol. 31(7):1268-72, 2010
                                                                                  5. Husein OF et al: Neuroglial heterotopia causing neonatal airway obstruction: presentation, management, and literature review. Eur J Pediatr. 167(12):1351-5, 2008
                                                                                  6. Riffaud L et al: Glial heterotopia of the face. J Pediatr Surg. 43(12):e1-3, 2008
                                                                                  7. De Biasio P et al: Prenatal diagnosis of a nasal glioma in the mid trimester. Ultrasound Obstet Gynecol. 27(5):571-3, 2006
                                                                                  8. Hedlund G: Congenital frontonasal masses: developmental anatomy, malformations, and MR imaging. Pediatr Radiol. 36(7):647-62; quiz 726-7, 2006
                                                                                  9. Huisman TA et al: Developmental nasal midline masses in children: neuroradiological evaluation. Eur Radiol. 14(2):243-9, 2004
                                                                                  10. Penner CR et al: Nasal glial heterotopia. Ear Nose Throat J. 83(2):92-3, 2004
                                                                                  11. Restrepo S et al: Nasal glioma. Ear Nose Throat J. 83(2):88-9, 2004
                                                                                  12. Penner CR et al: Nasal glial heterotopia: a clinicopathologic and immunophenotypic analysis of 10 cases with a review of the literature. Ann Diagn Pathol. 7(6):354-9, 2003
                                                                                  13. Rahbar R et al: Nasal glioma and encephalocele: diagnosis and management. Laryngoscope. 113(12):2069-77, 2003
                                                                                  14. Hoeger PH et al: Nasal glioma presenting as capillary haemangioma. Eur J Pediatr. 160(2):84-7, 2001
                                                                                  15. Shah J et al: Pedunculated nasal glioma: MRI features and review of the literature. J Postgrad Med. 45(1):15-7, 1999
                                                                                  16. Belden CJ et al: The developing anterior skull base: CT appearance from birth to 2 years of age. AJNR Am J Neuroradiol. 18(5):811-8, 1997
                                                                                  17. Barkovich AJ et al: Congenital nasal masses: CT and MR imaging features in 16 cases. AJNR Am J Neuroradiol. 12(1):105-16, 1991
                                                                                  18. Kennard CD et al: Congenital midline nasal masses: diagnosis and management. J Dermatol Surg Oncol. 16(11):1025-36, 1990
                                                                                  19. Morgan DW et al: Developmental nasal anomalies. J Laryngol Otol. 104(5):394-403, 1990
                                                                                  20. Younus M et al: Nasal glioma and encephalocele: two separate entities. Report of two cases. J Neurosurg. 64(3):516-9, 1986
                                                                                  21. Whitaker SR et al: Nasal glioma. Arch Otolaryngol. 107(9):550-4, 1981