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Neoplastic Lymphoproliferative Disorders
Jorge Alberto Carrillo-Bayona, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          TERMINOLOGY

          • Abbreviations

            • Non-Hodgkin lymphoma (NHL)
            • Hodgkin lymphoma (HL)
            • Primary pulmonary lymphoma (PPL)
            • Posttransplant lymphoproliferative disorder (PTLD)
          • Definitions

            • Neoplastic lymphoproliferative lung disorders are classified as primary, secondary, or associated with immunosuppression
            • PPL
              • Pulmonary monoclonal lymphoid tissue proliferation in patients with no detectable extrathoracic lymphoma for at least 3 months after initial diagnosis
                • Mucosa-associated lymphoid tissue (MALT) lymphoma (most common)
                • Diffuse large B-cell lymphoma (DLBCL) (10-19%)
                • Lymphomatoid granulomatosis (LG)
            • Secondary pulmonary lymphoma (SPL): Pulmonary involvement by systemic lymphoma or leukemia
              • Patterns: Lymphangitic, nodular, alveolar
                • NHL, HL, leukemia-associated lung disease
            • Lymphoproliferative lung disorders associated with immunosuppression
              • AIDS-related lymphoma (ARL)
              • PTLD

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • Nuclear Medicine Findings

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Microscopic Features

                        CLINICAL ISSUES

                        • Treatment

                          • MALT Lymphoma

                            • Lymphomatoid Granulomatosis

                              • Secondary Pulmonary Involvement by Lymphoma

                                • Secondary Pulmonary Involvement by Leukemia

                                  • AIDS-Related Lymphoma

                                    • Posttransplant Lymphoproliferative Disorder

                                      Selected References

                                      1. Kligerman SJ et al: Primary extranodal lymphoma of the thorax. Radiol Clin North Am. 54(4):673-87, 2016
                                      2. Sirajuddin A et al: Primary pulmonary lymphoid lesions: radiologic and pathologic findings. Radiographics. 36(1):53-70, 2016
                                      3. Carter BW et al: Multimodality imaging of cardiothoracic lymphoma. Eur J Radiol. 83(8):1470-82, 2014
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              TERMINOLOGY

                                              • Abbreviations

                                                • Non-Hodgkin lymphoma (NHL)
                                                • Hodgkin lymphoma (HL)
                                                • Primary pulmonary lymphoma (PPL)
                                                • Posttransplant lymphoproliferative disorder (PTLD)
                                              • Definitions

                                                • Neoplastic lymphoproliferative lung disorders are classified as primary, secondary, or associated with immunosuppression
                                                • PPL
                                                  • Pulmonary monoclonal lymphoid tissue proliferation in patients with no detectable extrathoracic lymphoma for at least 3 months after initial diagnosis
                                                    • Mucosa-associated lymphoid tissue (MALT) lymphoma (most common)
                                                    • Diffuse large B-cell lymphoma (DLBCL) (10-19%)
                                                    • Lymphomatoid granulomatosis (LG)
                                                • Secondary pulmonary lymphoma (SPL): Pulmonary involvement by systemic lymphoma or leukemia
                                                  • Patterns: Lymphangitic, nodular, alveolar
                                                    • NHL, HL, leukemia-associated lung disease
                                                • Lymphoproliferative lung disorders associated with immunosuppression
                                                  • AIDS-related lymphoma (ARL)
                                                  • PTLD

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • Nuclear Medicine Findings

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Microscopic Features

                                                            CLINICAL ISSUES

                                                            • Treatment

                                                              • MALT Lymphoma

                                                                • Lymphomatoid Granulomatosis

                                                                  • Secondary Pulmonary Involvement by Lymphoma

                                                                    • Secondary Pulmonary Involvement by Leukemia

                                                                      • AIDS-Related Lymphoma

                                                                        • Posttransplant Lymphoproliferative Disorder

                                                                          Selected References

                                                                          1. Kligerman SJ et al: Primary extranodal lymphoma of the thorax. Radiol Clin North Am. 54(4):673-87, 2016
                                                                          2. Sirajuddin A et al: Primary pulmonary lymphoid lesions: radiologic and pathologic findings. Radiographics. 36(1):53-70, 2016
                                                                          3. Carter BW et al: Multimodality imaging of cardiothoracic lymphoma. Eur J Radiol. 83(8):1470-82, 2014