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Neuroblastic Tumor
Kevin R. Moore, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Definitions

              • Neuroblastic tumors = ganglioneuroma (GN), ganglioneuroblastoma (GNB), and neuroblastoma (NB)
                • Embryonal tumors derived from neural crest cells

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Reporting Tips

                                                Selected References

                                                1. Estiar MA et al: MYCN gene amplification in patients with neuroblastic tumors. Cell Mol Biol (Noisy-le-grand). 60(3):23-8, 2014
                                                2. Irtan S et al: Minimally invasive surgery of neuroblastic tumors in children: Indications depend on anatomical location and image-defined risk factors. Pediatr Blood Cancer. ePub, 2014
                                                3. Fendler WP et al: High ¹²³I-MIBG uptake in neuroblastic tumours indicates unfavourable histopathology. Eur J Nucl Med Mol Imaging. 40(11):1701-10, 2013
                                                4. Gahr N et al: Diffusion-weighted MRI for differentiation of neuroblastoma and ganglioneuroblastoma/ganglioneuroma. Eur J Radiol. Epub ahead of print, 2010
                                                5. Aydin GB et al: Neurological complications of neuroblastic tumors: experience of a single center. Childs Nerv Syst. 26(3):359-65, 2010
                                                6. Bourezgui M et al: [Cauda equina syndrome revealing neuroblastoma.] Rev Neurol (Paris). 164(12):1048-51, 2008
                                                7. Loder RT et al: Abnormal rib number in childhood malignancy: implications for the scoliosis surgeon. Spine (Phila Pa 1976). 32(8):904-10, 2007
                                                8. Qiu Y et al: Adolescent thoracolumbar scoliosis secondary to ganglioneuroma: a two case report. Spine (Phila Pa 1976). 32(10):E326-9, 2007
                                                9. Pfluger T et al: Integrated imaging using MRI and 123I metaiodobenzylguanidine scintigraphy to improve sensitivity and specificity in the diagnosis of pediatric neuroblastoma. AJR Am J Roentgenol. 181(4):1115-24, 2003
                                                10. Rha SE et al: Neurogenic tumors in the abdomen: tumor types and imaging characteristics. Radiographics. 23(1):29-43, 2003
                                                11. Tateishi U et al: Adult neuroblastoma: radiologic and clinicopathologic features. J Comput Assist Tomogr. 27(3):321-6, 2003
                                                12. Lonergan GJ et al: Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. 22(4):911-34, 2002
                                                13. Meyer JS et al: Imaging of neuroblastoma and Wilms' tumor. Magn Reson Imaging Clin N Am. 10(2):275-302, 2002
                                                14. Siegel MJ et al: Staging of neuroblastoma at imaging: report of the radiology diagnostic oncology group. Radiology. 223(1):168-75, 2002
                                                15. Geoerger B et al: Metabolic activity and clinical features of primary ganglioneuromas. Cancer. 91(10):1905-13, 2001
                                                16. Kushner BH et al: Extending positron emission tomography scan utility to high-risk neuroblastoma: fluorine-18 fluorodeoxyglucose positron emission tomography as sole imaging modality in follow-up of patients. J Clin Oncol. 19(14):3397-405, 2001
                                                17. Joshi VV: Peripheral neuroblastic tumors: pathologic classification based on recommendations of international neuroblastoma pathology committee (Modification of shimada classification). Pediatr Dev Pathol. 3(2):184-99, 2000
                                                18. Schwab et al: Neuroblastic tumors of the adrenal gland and sympathetic nervous system. In Kleihues et al: Pathology and Genetics of Tumors of the Nervous System. Lyon: IARC Press. 153-61, 2000
                                                19. Perel Y et al: Clinical impact and prognostic value of metaiodobenzylguanidine imaging in children with metastatic neuroblastoma. J Pediatr Hematol Oncol. 21(1):13-8, 1999
                                                20. Sofka CM et al: Magnetic resonance imaging of neuroblastoma using current techniques. Magn Reson Imaging. 17(2):193-8, 1999
                                                21. Brodeur GM et al: International criteria for diagnosis, staging, and response to treatment in patients with neuroblastoma. J Clin Oncol. 6(12):1874-81, 1988
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Definitions

                                                            • Neuroblastic tumors = ganglioneuroma (GN), ganglioneuroblastoma (GNB), and neuroblastoma (NB)
                                                              • Embryonal tumors derived from neural crest cells

                                                          IMAGING

                                                          • General Features

                                                            • Radiographic Findings

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Ultrasonographic Findings

                                                                    • Nuclear Medicine Findings

                                                                      • Imaging Recommendations

                                                                        DIFFERENTIAL DIAGNOSIS

                                                                          PATHOLOGY

                                                                          • General Features

                                                                            • Staging, Grading, & Classification

                                                                              • Gross Pathologic & Surgical Features

                                                                                • Microscopic Features

                                                                                  CLINICAL ISSUES

                                                                                  • Presentation

                                                                                    • Demographics

                                                                                      • Natural History & Prognosis

                                                                                        • Treatment

                                                                                          DIAGNOSTIC CHECKLIST

                                                                                          • Consider

                                                                                            • Reporting Tips

                                                                                              Selected References

                                                                                              1. Estiar MA et al: MYCN gene amplification in patients with neuroblastic tumors. Cell Mol Biol (Noisy-le-grand). 60(3):23-8, 2014
                                                                                              2. Irtan S et al: Minimally invasive surgery of neuroblastic tumors in children: Indications depend on anatomical location and image-defined risk factors. Pediatr Blood Cancer. ePub, 2014
                                                                                              3. Fendler WP et al: High ¹²³I-MIBG uptake in neuroblastic tumours indicates unfavourable histopathology. Eur J Nucl Med Mol Imaging. 40(11):1701-10, 2013
                                                                                              4. Gahr N et al: Diffusion-weighted MRI for differentiation of neuroblastoma and ganglioneuroblastoma/ganglioneuroma. Eur J Radiol. Epub ahead of print, 2010
                                                                                              5. Aydin GB et al: Neurological complications of neuroblastic tumors: experience of a single center. Childs Nerv Syst. 26(3):359-65, 2010
                                                                                              6. Bourezgui M et al: [Cauda equina syndrome revealing neuroblastoma.] Rev Neurol (Paris). 164(12):1048-51, 2008
                                                                                              7. Loder RT et al: Abnormal rib number in childhood malignancy: implications for the scoliosis surgeon. Spine (Phila Pa 1976). 32(8):904-10, 2007
                                                                                              8. Qiu Y et al: Adolescent thoracolumbar scoliosis secondary to ganglioneuroma: a two case report. Spine (Phila Pa 1976). 32(10):E326-9, 2007
                                                                                              9. Pfluger T et al: Integrated imaging using MRI and 123I metaiodobenzylguanidine scintigraphy to improve sensitivity and specificity in the diagnosis of pediatric neuroblastoma. AJR Am J Roentgenol. 181(4):1115-24, 2003
                                                                                              10. Rha SE et al: Neurogenic tumors in the abdomen: tumor types and imaging characteristics. Radiographics. 23(1):29-43, 2003
                                                                                              11. Tateishi U et al: Adult neuroblastoma: radiologic and clinicopathologic features. J Comput Assist Tomogr. 27(3):321-6, 2003
                                                                                              12. Lonergan GJ et al: Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. 22(4):911-34, 2002
                                                                                              13. Meyer JS et al: Imaging of neuroblastoma and Wilms' tumor. Magn Reson Imaging Clin N Am. 10(2):275-302, 2002
                                                                                              14. Siegel MJ et al: Staging of neuroblastoma at imaging: report of the radiology diagnostic oncology group. Radiology. 223(1):168-75, 2002
                                                                                              15. Geoerger B et al: Metabolic activity and clinical features of primary ganglioneuromas. Cancer. 91(10):1905-13, 2001
                                                                                              16. Kushner BH et al: Extending positron emission tomography scan utility to high-risk neuroblastoma: fluorine-18 fluorodeoxyglucose positron emission tomography as sole imaging modality in follow-up of patients. J Clin Oncol. 19(14):3397-405, 2001
                                                                                              17. Joshi VV: Peripheral neuroblastic tumors: pathologic classification based on recommendations of international neuroblastoma pathology committee (Modification of shimada classification). Pediatr Dev Pathol. 3(2):184-99, 2000
                                                                                              18. Schwab et al: Neuroblastic tumors of the adrenal gland and sympathetic nervous system. In Kleihues et al: Pathology and Genetics of Tumors of the Nervous System. Lyon: IARC Press. 153-61, 2000
                                                                                              19. Perel Y et al: Clinical impact and prognostic value of metaiodobenzylguanidine imaging in children with metastatic neuroblastoma. J Pediatr Hematol Oncol. 21(1):13-8, 1999
                                                                                              20. Sofka CM et al: Magnetic resonance imaging of neuroblastoma using current techniques. Magn Reson Imaging. 17(2):193-8, 1999
                                                                                              21. Brodeur GM et al: International criteria for diagnosis, staging, and response to treatment in patients with neuroblastoma. J Clin Oncol. 6(12):1874-81, 1988