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Neuroblastoma, Thoracic
Alexander J. Towbin, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Abbreviations

          • Neuroblastoma (NBL)
        • Definitions

          • Malignant tumor of primitive neural crest cells

        IMAGING

        • General Features

          • Radiographic Findings

            • CT Findings

              • MR Findings

                • Ultrasonographic Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Biko DM et al: Mediastinal masses in children: radiologic-pathologic correlation. Radiographics. 41(4):E1186-207, 2021
                                          2. Oldridge DA et al: Differences in genomic profiles and outcomes between thoracic and adrenal neuroblastoma. J Natl Cancer Inst. 111(11):1192-201, 2019
                                          3. Chen AM et al: A review of neuroblastoma image-defined risk factors on magnetic resonance imaging. Pediatr Radiol. 48(9):1337-47, 2018
                                          4. Swift CC et al: Updates in diagnosis, management, and treatment of neuroblastoma. Radiographics. 38(2):566-80, 2018
                                          5. Brisse HJ et al: Radiogenomics of neuroblastomas: relationships between imaging phenotypes, tumor genomic profile and survival. PLoS One. 12(9):e0185190, 2017
                                          6. Pavlus JD et al: Imaging of thoracic neurogenic tumors. AJR Am J Roentgenol. 1-10, 2016
                                          7. Vo KT et al: Clinical, biologic, and prognostic differences on the basis of primary tumor site in neuroblastoma: a report from the international neuroblastoma risk group project. J Clin Oncol. 32(28):3169-76, 2014
                                          8. Brisse HJ et al: Guidelines for imaging and staging of neuroblastic tumors: consensus report from the International Neuroblastoma Risk Group Project. Radiology. 261(1):243-57, 2011
                                          9. Demir HA et al: Thoracic neuroblastic tumors in childhood. Pediatr Blood Cancer. 54(7):885-9, 2010
                                          10. Monclair T et al: The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report. J Clin Oncol. 27(2):298-303, 2009
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Neuroblastoma (NBL)
                                                • Definitions

                                                  • Malignant tumor of primitive neural crest cells

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Ultrasonographic Findings

                                                          • Nuclear Medicine Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Staging, Grading, & Classification

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Biko DM et al: Mediastinal masses in children: radiologic-pathologic correlation. Radiographics. 41(4):E1186-207, 2021
                                                                                  2. Oldridge DA et al: Differences in genomic profiles and outcomes between thoracic and adrenal neuroblastoma. J Natl Cancer Inst. 111(11):1192-201, 2019
                                                                                  3. Chen AM et al: A review of neuroblastoma image-defined risk factors on magnetic resonance imaging. Pediatr Radiol. 48(9):1337-47, 2018
                                                                                  4. Swift CC et al: Updates in diagnosis, management, and treatment of neuroblastoma. Radiographics. 38(2):566-80, 2018
                                                                                  5. Brisse HJ et al: Radiogenomics of neuroblastomas: relationships between imaging phenotypes, tumor genomic profile and survival. PLoS One. 12(9):e0185190, 2017
                                                                                  6. Pavlus JD et al: Imaging of thoracic neurogenic tumors. AJR Am J Roentgenol. 1-10, 2016
                                                                                  7. Vo KT et al: Clinical, biologic, and prognostic differences on the basis of primary tumor site in neuroblastoma: a report from the international neuroblastoma risk group project. J Clin Oncol. 32(28):3169-76, 2014
                                                                                  8. Brisse HJ et al: Guidelines for imaging and staging of neuroblastic tumors: consensus report from the International Neuroblastoma Risk Group Project. Radiology. 261(1):243-57, 2011
                                                                                  9. Demir HA et al: Thoracic neuroblastic tumors in childhood. Pediatr Blood Cancer. 54(7):885-9, 2010
                                                                                  10. Monclair T et al: The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report. J Clin Oncol. 27(2):298-303, 2009