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Neuroblastoma
Paula J. Woodward, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Malignant tumor composed of neuroblasts, arising within sympathetic neural plexus or adrenal medulla

            IMAGING

            • General Features

              • Ultrasonographic Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Lesieur E et al: Prenatal assessment of atypical adrenal glands: a systematic approach for diagnosis. J Ultrasound Med. ePub, 2020
                                        2. Liang WH et al: Tailoring therapy for children with neuroblastoma on the basis of risk group classification: past, present, and future. JCO Clin Cancer Inform. 4:895-905, 2020
                                        3. Langenberg-Ververgaert KPS et al: MYCN amplified relapse following resolution of MYCN nonamplified 4s neuroblastoma with placental involvement: a case report and review of the literature. J Pediatr Hematol Oncol. 41(5):388-91, 2019
                                        4. Sokol E et al: The evolution of risk classification for neuroblastoma. Children (Basel). 6(2), 2019
                                        5. Starchenko II et al: The observation of congenital retroperitoneal large size neuroblastoma. Exp Oncol. 41(2):179-81, 2019
                                        6. Park Y et al: Prenatally detected thoracic neuroblastoma. Obstet Gynecol Sci. 61(2):278-81, 2018
                                        7. Koh V et al: Neuroblastoma in children under 12 months in Singapore--15-year experience and outcomes from KKH. Fetal Pediatr Pathol. 34(3):155-61, 2015
                                        8. Nagaraj UD et al: Diagnostic imaging of fetal and neonatal abdominal and soft tissue tumors. Curr Pediatr Rev. 11(3):143-50, 2015
                                        9. Wader JV et al: Disseminated congenital neuroblastoma - an autopsy case report. J Clin Diagn Res. 9(5):ED03-4, 2015
                                        10. Gupta R et al: Stage 4S bilateral adrenal neuroblastoma in a newborn. APSP J Case Rep. 5(1):9, 2014
                                        11. Kume A et al: Congenital neuroblastoma with placental involvement. Int J Clin Exp Pathol. 7(11):8198-204, 2014
                                        12. Maki E et al: Imaging and differential diagnosis of suprarenal masses in the fetus. J Ultrasound Med. 33(5):895-904, 2014
                                        13. Fisher JP et al: Neonatal neuroblastoma. Semin Fetal Neonatal Med. 17(4):207-15, 2012
                                        14. Avni FE et al: Tumours of the fetal body: a review. Pediatr Radiol. 39(11):1147-57, 2009
                                        15. Monclair T et al: The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report. J Clin Oncol. 27(2):298-303, 2009
                                        16. Blackman SC et al: Prenatal diagnosis and subsequent treatment of an intermediate-risk paraspinal neuroblastoma: case report and review of the literature. Fetal Diagn Ther. 24(2):119-25, 2008
                                        17. Isaacs H Jr: Fetal and neonatal neuroblastoma: retrospective review of 271 cases. Fetal Pediatr Pathol. 26(4):177-84, 2007
                                        18. Nuchtern JG: Perinatal neuroblastoma. Semin Pediatr Surg. 15(1):10-6, 2006
                                        19. Woodward PJ et al: From the archives of the AFIP: a comprehensive review of fetal tumors with pathologic correlation. Radiographics. 25(1):215-42, 2005
                                        20. Houlihan C et al: Prenatal diagnosis of neuroblastoma with sonography and magnetic resonance imaging. J Ultrasound Med. 23(4):547-50, 2004
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Definitions

                                                    • Malignant tumor composed of neuroblasts, arising within sympathetic neural plexus or adrenal medulla

                                                  IMAGING

                                                  • General Features

                                                    • Ultrasonographic Findings

                                                      • MR Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Staging, Grading, & Classification

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          DIAGNOSTIC CHECKLIST

                                                                          • Consider

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Lesieur E et al: Prenatal assessment of atypical adrenal glands: a systematic approach for diagnosis. J Ultrasound Med. ePub, 2020
                                                                              2. Liang WH et al: Tailoring therapy for children with neuroblastoma on the basis of risk group classification: past, present, and future. JCO Clin Cancer Inform. 4:895-905, 2020
                                                                              3. Langenberg-Ververgaert KPS et al: MYCN amplified relapse following resolution of MYCN nonamplified 4s neuroblastoma with placental involvement: a case report and review of the literature. J Pediatr Hematol Oncol. 41(5):388-91, 2019
                                                                              4. Sokol E et al: The evolution of risk classification for neuroblastoma. Children (Basel). 6(2), 2019
                                                                              5. Starchenko II et al: The observation of congenital retroperitoneal large size neuroblastoma. Exp Oncol. 41(2):179-81, 2019
                                                                              6. Park Y et al: Prenatally detected thoracic neuroblastoma. Obstet Gynecol Sci. 61(2):278-81, 2018
                                                                              7. Koh V et al: Neuroblastoma in children under 12 months in Singapore--15-year experience and outcomes from KKH. Fetal Pediatr Pathol. 34(3):155-61, 2015
                                                                              8. Nagaraj UD et al: Diagnostic imaging of fetal and neonatal abdominal and soft tissue tumors. Curr Pediatr Rev. 11(3):143-50, 2015
                                                                              9. Wader JV et al: Disseminated congenital neuroblastoma - an autopsy case report. J Clin Diagn Res. 9(5):ED03-4, 2015
                                                                              10. Gupta R et al: Stage 4S bilateral adrenal neuroblastoma in a newborn. APSP J Case Rep. 5(1):9, 2014
                                                                              11. Kume A et al: Congenital neuroblastoma with placental involvement. Int J Clin Exp Pathol. 7(11):8198-204, 2014
                                                                              12. Maki E et al: Imaging and differential diagnosis of suprarenal masses in the fetus. J Ultrasound Med. 33(5):895-904, 2014
                                                                              13. Fisher JP et al: Neonatal neuroblastoma. Semin Fetal Neonatal Med. 17(4):207-15, 2012
                                                                              14. Avni FE et al: Tumours of the fetal body: a review. Pediatr Radiol. 39(11):1147-57, 2009
                                                                              15. Monclair T et al: The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report. J Clin Oncol. 27(2):298-303, 2009
                                                                              16. Blackman SC et al: Prenatal diagnosis and subsequent treatment of an intermediate-risk paraspinal neuroblastoma: case report and review of the literature. Fetal Diagn Ther. 24(2):119-25, 2008
                                                                              17. Isaacs H Jr: Fetal and neonatal neuroblastoma: retrospective review of 271 cases. Fetal Pediatr Pathol. 26(4):177-84, 2007
                                                                              18. Nuchtern JG: Perinatal neuroblastoma. Semin Pediatr Surg. 15(1):10-6, 2006
                                                                              19. Woodward PJ et al: From the archives of the AFIP: a comprehensive review of fetal tumors with pathologic correlation. Radiographics. 25(1):215-42, 2005
                                                                              20. Houlihan C et al: Prenatal diagnosis of neuroblastoma with sonography and magnetic resonance imaging. J Ultrasound Med. 23(4):547-50, 2004